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anhydrotetrodotoxin

anhydrotetrodotoxin Structure
anhydrotetrodotoxin structure
CAS No.
13072-89-4
Chemical Name:
anhydrotetrodotoxin
Synonyms
9-anhydro-TTX;4,9-Anhydro-TTX;anhydrotetrodotoxin;4,9-Anhydrotetrodotoxin;4,9-Dideoxy-4β,9β-epoxytetrodotoxin;(8S)-4,9-Dideoxy-4β,9β-epoxytetrodotoxin;4,9Anhydrotetrodotoxin,4,9 Anhydrotetrodotoxin;(4S,5aS,6S,8R,9S,10S,11S,11aR,12R)-2-Amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)-6,10-epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol;6,10-Epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol, 2-amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)-, (4S,5aS,6S,8R,9S,10S,11S,11aR,12R)-
CBNumber:
CB51328746
Molecular Formula:
C11H15N3O7
Molecular Weight:
301.25
MDL Number:
MFCD01682463
MOL File:
13072-89-4.mol
Last updated:2023-06-30 15:45:59
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anhydrotetrodotoxin Properties

storage temp. -20°
solubility Soluble in Ethanol (up to 10 mg/ml).
form A solid or film
color Colorless
Water Solubility Soluble to 1 mg/ml in water
Stability Stable for 2 years from date of purchase as supplied. Protect from exposure to light or moisture. Solutions are not stable. Solutions must be prepared fresh and used within 1 working day.

anhydrotetrodotoxin price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 19084 4,9-Anhydrotetrodotoxin ≥98% 13072-89-4 100μg $242 2024-03-01 Buy
Tocris 6159 4,9-Anhydrotetrodotoxin ≥98%(HPLC) 13072-89-4 100U $227 2021-12-16 Buy
Product number Packaging Price Buy
19084 100μg $242 Buy
6159 100U $227 Buy

anhydrotetrodotoxin Chemical Properties,Uses,Production

Description

4,9-Anhydrotetrodotoxin (4,9-anhydro-TTX) is a derivative of TTX that selectively blocks inward sodium current through Nav1.6 voltage-activated sodium channels (IC50 = 7.8 nM in Xenopus oocytes). It demonstrates IC50 values of 1.3, 0.34, 0.99, 78.5, 1.3, and >30 μM for Nav1.2, Nav1.3, Nav1.4, Nav1.5, Nav1.7, and Nav1.8, respectively.

storage

Store at -20°C

References

1) Rosker?et al. (2007),?The TTX metabolite 4,9-anhydro-TTX is a highly specific blocker of the Na(v1.6) voltage-dependent sodium channel; Am.J.Physiol.Cell Physiol.,?293?C783. 2) Denomme?et al.?(2020),??The voltage-gated sodium channel inhibitor, 4,9-anhydrotetrodotoxin, blocks human Nav1.1 in addition to Nav1.6;?Neurosci. Lett.?724?134853

anhydrotetrodotoxin Preparation Products And Raw materials

Raw materials

Preparation Products

anhydrotetrodotoxin Suppliers

Global( 19)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd 		+86-19164747840 +86-13119157289 13119157289@163.com China 2971 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
BOC Sciences -- info@bocsci.com USA 0 65
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
Energy Chemical 021-58432009 400-005-6266 marketing@energy-chemical.com China 44941 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24018 58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd 18049165724 13186333400 cuichengbio@163.com China 2605 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8740 58
United States Biological -- sales@advtechind.com United States 6106 58
Supplier Advantage
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd 		58
Shanghai Hongye Biotechnology Co. Ltd 58
BOC Sciences 65
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Energy Chemical 58
TargetMol Chemicals Inc. 58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
United States Biological 58

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anhydrotetrodotoxin (8S)-4,9-Dideoxy-4β,9β-epoxytetrodotoxin 4,9-Anhydrotetrodotoxin 4,9-Dideoxy-4β,9β-epoxytetrodotoxin (4S,5aS,6S,8R,9S,10S,11S,11aR,12R)-2-Amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)-6,10-epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol 6,10-Epoxy-4,8,11a-metheno-11aH-oxocino[4,3-f][1,3,5]oxadiazepine-6,9,11-triol, 2-amino-1,4,5a,6,8,9,10,11-octahydro-9-(hydroxymethyl)-, (4S,5aS,6S,8R,9S,10S,11S,11aR,12R)- 9-anhydro-TTX 4,9Anhydrotetrodotoxin,4,9 Anhydrotetrodotoxin 4,9-Anhydro-TTX 13072-89-4