14,15-LEUKOTRIENE D4
- CAS No.
- 75290-64-1
- Chemical Name:
- 14,15-LEUKOTRIENE D4
- Synonyms
- Eoxin D4;14,15-LEUKOTRIENE D4;Glycine, S-[(1R,2E,4E,6Z,9Z)-13-carboxy-1-[(1S)-1-hydroxyhexyl]-2,4,6,9-tridecatetraen-1-yl]-L-cysteinyl-
- CBNumber:
- CB5226768
- Molecular Formula:
- C25H40N2O6S
- Molecular Weight:
- 496.66
- MDL Number:
- MFCD00211502
- MOL File:
- 75290-64-1.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501 | |||||||||
| NFPA 704 |
|
14,15-LEUKOTRIENE D4 price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 10011361 | 14,15-Leukotriene D4 ≥97% | 75290-64-1 | 25μg | $127 | 2024-03-01 | Buy |
| Cayman Chemical | 10011361 | 14,15-Leukotriene D4 ≥97% | 75290-64-1 | 50μg | $236 | 2024-03-01 | Buy |
| Cayman Chemical | 10011361 | 14,15-Leukotriene D4 ≥97% | 75290-64-1 | 100μg | $447 | 2024-03-01 | Buy |
| TRC | E561500 | EoxinD4 | 75290-64-1 | 50g | $195 | 2021-12-16 | Buy |
14,15-LEUKOTRIENE D4 Chemical Properties,Uses,Production
Description
14,15-Leukotriene D4 (14,15-LTD4) is a member of an alternate class of LTs synthesized by a pathway involving the dual actions of 15- and 12-lipoxygenases (15- and 12-LOs) on arachidonic acid via 15-HpETE and 14,15-LTA4 intermediates. 14,15-LTD4 is classified as an eoxin (EXD4), because it is formed mostly by eosinophils. However, mast cells and nasal polyps can synthesize 14,15-LTD4 as well. Little is known about the physiological actions of 14,15-LTD4. It has weak contractile activity on both guinea pig ileum and pulmonary parenchyma in contrast to the effects of 5-LO-derived LTs. However, in an in vitro permeability assay, 14,15-LTD4 can increase vascular permeability of human endothelial cell monolayers, with similar potency to that of 5-LO-derived LTs, resulting in plasma leakage, a hallmark of inflammation.
Uses
Eoxin D4 is synthesized via the 15-lipoxygenase-1 pathway in human eosinophils. Eoxins are proinflammatory arachidonic acid metabolites produced by mast cells.
Definition
ChEBI: Eoxin D4 is a leukotriene that is the 14R-(S-cysteinylglycyl),15S-hydroxy derivative of (5Z,8Z,10E,12E)-icosa-7,9,11,14-tetraenoic acid. It has a role as a metabolite. It is a leukotriene and an eoxin. It is functionally related to a (5Z,8Z,10E,12E)-icosatetraenoic acid.
14,15-LEUKOTRIENE D4 Preparation Products And Raw materials
Raw materials
Preparation Products
14,15-LEUKOTRIENE D4 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 | 3427709316@qq.com | China | 7984 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.com | China | 24246 | 58 |