ALPHA-ETHYL-3-HYDROXY-2,4,6-TRIIODOHYDROCINNAMIC ACID
- CAS No.
- 96-84-4
- Chemical Name:
- ALPHA-ETHYL-3-HYDROXY-2,4,6-TRIIODOHYDROCINNAMIC ACID
- Synonyms
- teridax;Jodoprol;Iophenoic;Tiloshade;Trilombrine;IophenoicAcid;IOPHENOXIC ACID;triiodoethionicacid;alpha-ethyl-beta-(3-hydrox;Acide iophenoique [INN-French]
- CBNumber:
- CB5266250
- Molecular Formula:
- C11H11I3O3
- Molecular Weight:
- 571.92
- MDL Number:
- MFCD00133419
- MOL File:
- 96-84-4.mol
| Melting point | 146-148 °C (lit.) |
|---|---|
| Boiling point | 459.0±45.0 °C(Predicted) |
| Density | 2.2890 (estimate) |
| pka | pKa 7.5(H2O,(extrap)) (Uncertain) |
| Merck | 13,5077 |
| FDA UNII | 73TJC7JGUY |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 22-36/37/38 |
| Safety Statements | 26-37/39 |
| WGK Germany | 3 |
| RTECS | MW5280000 |
| Toxicity | LD50 i.v. in mice: 374 mg/kg (Hoppe) |
ALPHA-ETHYL-3-HYDROXY-2,4,6-TRIIODOHYDROCINNAMIC ACID price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 361046 | α-Ethyl-3-hydroxy-2,4,6-triiodohydrocinnamic acid 97% | 96-84-4 | 5g | $216 | 2024-03-01 | Buy |
| American Custom Chemicals Corporation | HCH0066813 | ALPHA-ETHYL-3-HYDROXY-2,4,6-TRIIODOHYDROCINNAMIC ACID 95.00% | 96-84-4 | 5G | $1164.14 | 2021-12-16 | Buy |
ALPHA-ETHYL-3-HYDROXY-2,4,6-TRIIODOHYDROCINNAMIC ACID Chemical Properties,Uses,Production
Originator
Teridax,Schering
Uses
α-Ethyl-3-hydroxy-2,4,6-triiodohydrocinnamic acid (iophenoxic acid ) was used as marker in “bait acceptance” studies conducted on various animal species. It was used in the direct quantitation of iophenoxic acid in porcine serum samples by a liquid chromatographic-electrospray ionization mass spectrometric technique.
Definition
ChEBI: Iophenoic acid is a member of benzenes and a monocarboxylic acid.
Manufacturing Process
A mixture of m-hydroxy-benzaldehyde, fused sodium propionate and of
butyric anhydride was stirred and refluxed at heating.
The mixture was then poured into water and acidified with hydrochloric acid.
The organic material was extracted with chloroform, the chloroform was
exaporated, and the residue stirred for one and 1.5 h with dilute potassium
hydroxide solution. Acetic acid was added to make the solution almost neutral,
but still slightly basic, the mixture was stirred with activated charcoal for
about 15 min, filtered, and the filtrate acidified to Congo red with hydrochloric
acid. A crystalline product was obtained upon cooling for several hours, and
this was collected by filtration and recrystallized from water giving α-ethyl-mhydroxycinnamic acid.
A solution of α-ethyl-m-hydroxycinnamic acid and potassium hydroxide in
water was added to 3% sodium amalgam, and the mixture was stirred while
heating on a steam bath for several hours. The mixture was then cooled, the
mercury separated, and the reaction mixture was acidified and extracted with
ether. The ether extracts were concentrated giving a residue containing α-
ethyl-β-(m-hydroxyphenyl)propionic acid.
α-Ethyl-β-(m-hydroxyphenyl)propionic acid was dissolved in acetic acid. The
solution was warmed on a steam bath, and water was added followed iodine
monochloride. The mixture was stirred and heated for several hours, and
water was then added to cause precipitation of the product. The semi-solid
precipitate was triturated with a small amount of 95% alcohol, collected by
filtration and washed with low boiling petroleum ether. Recrystallization from
dilute alcohol, using charcoal for decolorization, gave α-ethyl-β-(2,4,6-triiodo-
3-hydroxyphenyl)propionic acid.
brand name
Teridax (Schering).
Therapeutic Function
Diagnostic aid
General Description
α-Ethyl-3-hydroxy-2,4,6-triiodohydrocinnamic acid (Iophenoxic acid ) is an organic, iodine-containing compound. Iophenoxic acid is an iodinated radiocontrast agent, its clinical use has been withdrawn due to its exceptionally long half-life in the body, since it has high-affinity binding to human serum albumin (HSA). Structural basis of its interaction with HSA has been evaluated.
ALPHA-ETHYL-3-HYDROXY-2,4,6-TRIIODOHYDROCINNAMIC ACID Preparation Products And Raw materials
Raw materials
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Preparation Products
ALPHA-ETHYL-3-HYDROXY-2,4,6-TRIIODOHYDROCINNAMIC ACID Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| Suzhou Victorypharm Co.,Ltd. | +86-13916956214 | sales@victory-pharm.com | China | 1301 | 58 |
| PT CHEM GROUP LIMITED | +86-85511178 +86-85511178 | peter68@ptchemgroup.com | China | 35453 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Energy Chemical | 021-021-58432009 400-005-6266 | sales8178@energy-chemical.com | China | 44700 | 61 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-021-64543801 13764082696 | 2355241799@qq.com | China | 42982 | 64 |
| Suzhou APIC Biotechnology Co., Ltd. | 0512-65757861-8000 | sales@apiclab.cn | China | 273 | 58 |
| Zhengzhou HongSheng Pharmaceutical Co., Ltd. | 1352-6885213 15637198702 | xpkchem@163.com | China | 3998 | 58 |
| Suzhou Laing Biological Technology Co., LTD | 0512-62968256 18550502935 | export@laingbiotec.com | China | 1046 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |