3-Morpholinosydnonimine hydrochloride
- CAS No.
- 16142-27-1
- Chemical Name:
- 3-Morpholinosydnonimine hydrochloride
- Synonyms
- SIN-1;SIN-1 HCL;LINSIDOMINE;SIN-1 CHLORIDE;LINSIDOMINE HCL;SIN-I HYDROCHLORIDE;SIN-1 HYDROCHLORIDE;MolsidoMine IMpurity A;Linsidomine (chloride);Molsidomine Impurity 7
- CBNumber:
- CB5370997
- Molecular Formula:
- C6H11ClN4O2
- Molecular Weight:
- 206.63
- MDL Number:
- MFCD00221615
- MOL File:
- 16142-27-1.mol
- MSDS File:
- SDS
| Melting point | 186 °C |
|---|---|
| Density | 1.303 at 20℃ |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 35 mg/ml) or in Water (up to 65 mg/ml) |
| form | White solid |
| color | White |
| Water Solubility | soluble |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions must be prepared fresh and cannot be stored. |
| LogP | -6.28 at 25℃ |
| CAS DataBase Reference | 16142-27-1(CAS DataBase Reference) |
| FDA UNII | Y0054U597M |
| ATC code | C01DX18 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Safety Statements | 24/25 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | WU7687800 | |||||||||
| HS Code | 29349990 | |||||||||
| NFPA 704 |
|
3-Morpholinosydnonimine hydrochloride price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | M5793 | 3-Morpholinosydnonimine hydrochloride (consistent with structure, NMR) | 16142-27-1 | 25mg | $228 | 2024-03-01 | Buy |
| Sigma-Aldrich | 567028 | SIN-1, Hydrochloride Nitric oxide (NO) donor. | 16142-27-1 | 20mg | $155 | 2024-03-01 | Buy |
| Cayman Chemical | 82220 | SIN-1 (chloride) ≥99% | 16142-27-1 | 10mg | $32 | 2024-03-01 | Buy |
| Sigma-Aldrich | M5793 | 3-Morpholinosydnonimine hydrochloride (consistent with structure, NMR) | 16142-27-1 | 100mg | $760 | 2024-03-01 | Buy |
| Cayman Chemical | 82220 | SIN-1 (chloride) ≥99% | 16142-27-1 | 50mg | $131 | 2024-03-01 | Buy |
3-Morpholinosydnonimine hydrochloride Chemical Properties,Uses,Production
Description
As the active metabolite of molsidomine, SIN-
Chemical Properties
White Crystalline Solid
Uses
3-Morpholinosydnonimine hydrochloride has been used:
- as a peroxynitrite donor standard to study the accumulation of peroxynitrite?in?Arabidopsis thaliana
- to study its effects on nitrosative stress in human brain vascular pericytes and human embryonic kidney cells
- as a ROS to study its effects on mouse embryonic fibroblasts
Uses
SIN-1 is a metabolite of the vasodilator molsidomine and is considered to be a peroxynitrite releasing compound
Uses
3-Morpholinosydnonimine hydrochloride is a metabolite of the vasodilator Molsidomine (M488002) and is considered to be a peroxynitrite releasing compound. Molsidomine Impurity A.
Indications
Linsidomine (SIN-1) is an active metabolite of the antianginal drug molsidomine. Its mechanism of action upon the corpus cavernosum involves the release of nitric oxide. Injected intracavernosally it can produce penile erections, but its clinical usefulness has not been fully established.
Biological Activity
This compound (the active product of the prodrug SIN-10, molsidomine) acts as a vasodilator and inhibitor of platelet aggregation; longer acting than nitroprusside or nitroglycerin. Decreases myocardial necrosis and reperfusion-induced endothelial dysfunction in models of myocardial ischemia-reperfusion.
Biochem/physiol Actions
3-Morpholinosydnonimine participates in the inhibition of cysteine proteases.
storage
Store at +4°C
References
1) Nishikawa?et al.?(1982)?Inhibition of platelet aggregation and stimulation of guanylate cyclase by an antianginal agent molsidomine and its metabolites;?J. Pharmacol. Exp. Ther.?220?183 2) Hogg?et al.?(1992)?Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide; Biochem. J.?281?419 3) Kirsch?et al.?(1998)?Hydrogen peroxide formation by reaction of peroxynitrite with HEPES and related tertiary amines. Implications for a general mechanism.; J. Biol. Chem.?273?12716 4) Priora?et al.?(2011)?In vitro inhibition of human and rat platelets by NO donors nitrosoglutathione sodium nitroprusside and SIN-1 through activation of cGMP independent pathways; Pharmacol. Res.?64?289 5) Ren?et al.?(2017)?Identification of a New Function of Cardiovascular Disease Drug 3-Morpholinosydnonimine Hydrochloride as an Amyloid-β Aggregation Inhibitor;?ACS Omega.?2?243
3-Morpholinosydnonimine hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 | sales@aochuangchem.com | China | 9425 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50000 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33350 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
View Lastest Price from 3-Morpholinosydnonimine hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-09-15 | 3-Morpholinosydnonimine hydrochloride
16142-27-1
|
US $0.00-0.00 / KG | 1KG | 98% | 1ton | Henan Aochuang Chemical Co.,Ltd. | |
 |
2019-12-26 | 3-Morpholinosydnonimine hydrochloride
16142-27-1
|
US $1.00 / KG | 1KG | ≥98% | g/kg/Ton | Career Henan Chemical Co |
-
- 3-Morpholinosydnonimine hydrochloride
16142-27-1
- US $0.00-0.00 / KG
- 98%
- Henan Aochuang Chemical Co.,Ltd.
-
- 3-Morpholinosydnonimine hydrochloride
16142-27-1
- US $1.00 / KG
- ≥98%
- Career Henan Chemical Co