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D-Ephedrine hydrochloride

CAS No.
24221-86-1
Chemical Name:
D-Ephedrine hydrochloride
Synonyms
CPDD 0048;d-Ephedrine HCl;ErythromycinBaseUsp23;1S,2R(+)-Ephedrine HCl;D-(+)-EPHEDRINE HYDROCHLORIDE;(+)-Ephedrine (hydrochloride);2-MethylaMino-1-phenylpropan-2-ol;(1S,2R)-(+)-EPHEDRINE HYDROCHLORIDE;Ephedrine, hydrochloride, (+)- (8CI);(1S,2R)-(+)-EPHEDRINE HYDROCHLORIDE 99%
CBNumber:
CB5453027
Molecular Formula:
C10H16ClNO
Molecular Weight:
201.69
MDL Number:
MFCD00064551
MOL File:
24221-86-1.mol
Last updated:2023-06-08 09:02:13

D-Ephedrine hydrochloride Properties

Melting point 218-220 °C(lit.)
alpha 34.3 º (c=5, H2O)
Flash point 9℃
storage temp. Refrigerator
solubility DMF: 10 mg/ml; DMSO: 3 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 5 mg/ml
form A crystalline solid
optical activity [α]23/D +34.3°, c = 5 in H2O
BRN 6118541
CAS DataBase Reference 24221-86-1(CAS DataBase Reference)
EPA Substance Registry System Benzenemethanol, .alpha.-[(1R)-1-(methylamino)ethyl]-, hydrochloride, (.alpha.S)- (24221-86-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS02,GHS06,GHS08
Signal word  Danger
Hazard statements  H225-H301+H311+H331-H370
Precautionary statements  P210-P280-P301+P310+P330-P302+P352+P312-P304+P340+P311
Hazard Codes  Xn,T,F
Risk Statements  22-39/23/24/25-23/24/25-11
Safety Statements  22-25-45-36/37-16-7
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  3
RTECS  KB1925000
HS Code  29394100
NFPA 704
0
2 0

D-Ephedrine hydrochloride Chemical Properties,Uses,Production

Chemical Properties

white crystalline powder

Uses

α- and β-Adrenergic agonist. Bronchodilator.

Safety Profile

A poison by intraperitoneal, subcutaneous, and intravenous routes. When heated to decomposition it emits very toxic fumes of HCl and NOx. See also EPHEDRINE

Purification Methods

Recrystallise the hydrochloride from EtOH/Et2O. The free base crystallises from *C6H6 with m 40-41o (Skita et al. Chem Ber 66 974 1933]. [Beilstein 13 H 254, 13 II 375, 13 III 1721, 13 IV 1879.]

D-Ephedrine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

2-MethylaMino-1-phenylpropan-2-ol D-(+)-EPHEDRINE HYDROCHLORIDE d-alpha-(1-methylaminoethyl)benzyl alcohol D-ALPHA-(1-METHYLAMINOETHYL)BENZYL ALCOHOL HYDROCHLORIDE alpha-(1-(methylamino)ethyl)-,hydrochloride,(s-(r*,s*))-benzenemethano alpha-[1-(methylamino)ethyl]-,hydrochloride,[s-(theta,s)]-benzenemethano (1S,2R)-(+)-EPHEDRINE HYDROCHLORIDE (1S,2R)-(+)-ALPHA-(1-METHYLAMINOETHYL)BENZYL ALCOHOL HYDROCHLORIDE (1S,2R)-2-METHYLAMINO-1-PHENYL-1-PROPANOL HYDROCHLORIDE d-Ephedrine HCl 2-methylamino-1-phenylpropan-2-ol hydrochloride (1S,2R)-(+)-EPHEDRINE HYDROCHLORIDE 99% ErythromycinBaseUsp23 Benzenemethanol, .alpha.-(1R)-1-(methylamino)ethyl-, hydrochloride, (.alpha.S)- (1s,2r)-(+)-α-(1-methylaminoethyl)benzyl alcohol hydrochloride (1S,2R)-(+)-2-(Methylamino)-1-phenylpropan-1-ol hydrochloride Benzenemethanol, α-[(1R)-1-(methylamino)ethyl]-, hydrochloride, (αS)- Benzenemethanol, α-[1-(methylamino)ethyl]-, hydrochloride, [S-(R*,S*)]- CPDD 0048 Ephedrine, hydrochloride, (+)- (8CI) (1S,2R)-(+)-α-(1-Methylaminoethyl)benzyl alcohol hydrochloride, (1S,2R)-(+)-2-Methylamino-1-phenyl-1-propanol hydrochloride, D-α-(1-Methylaminoethyl)benzyl alcohol hydrochloride (1S,2R)-2-Methylamino-1-phenyl-1-propanol hydrochloride, D-α-(1-Methylaminoethyl)benzyl alcohol hydrochloride 1S,2R(+)-Ephedrine HCl (1S,2R)-2-Methylamino-1-phenylpropan-1-ol Benzenemethanol, alpha-(1-(methylamino)ethyl)-, hydrochloride, (S-(R*,S*))- (1S,2R)-(+)-Ephedrine hydrochloride,99% Methanol(Test 1S,2R(+)-Ephedrine HCl 1.0 mg/mL as free base) α-[1-(MethylaMino)ethyl]benzeneMethanol Hydrochloride (+)-Ephedrine (hydrochloride) 24221-86-1 AMINE Ephedrine Derivatives Asymmetric Synthesis Chiral Auxiliaries Amines Aromatics Chiral Reagents Intermediates & Fine Chemicals Pharmaceuticals Pharmaceutical Raw Materials