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Fidarestat

Fidarestat structure

CAS No.: 136087-85-9

Chemical Name:: Fidarestat

Synonyms: Aldos;Sk 860;CS-489;SNK-860;fidarestat;Fidarestat (SNK-860;(2S,4S)-6-Fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide;(2s,4s)-2-aminoformyl-6-fluoro-spiro[chroman-4,4'-imidazolidine]-2',5'-dione;(2s,4s)-6-fluoro-2',5'-dioxo-2,3-dihydrospiro[chromene-4,4'-imidazolidine]-2-carboxamide;(2S,4S)-2,3-Dihydro-6-fluoro-2',5'-dioxospiro[4H-1-benzopyran-4,4'-imidazolidine]-2-carboxamide

CBNumber:: CB5855234

Molecular Formula:: C12H10FN3O4

Molecular Weight:: 279.22

MDL Number:: MFCD00919183

MOL File:: 136087-85-9.mol

MSDS File:: SDS

Last updated:2023-06-08 09:02:50

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Fidarestat Properties

Density	1.61±0.1 g/cm3(Predicted)
solubility	DMF: 3 mg/ml; DMSO: 5 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 1 mg/ml
form	A crystalline solid
pka	8.46±0.40(Predicted)
FDA UNII	8SH8T1164U

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

NFPA 704

	0
3		0

Fidarestat price More Price(10)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	21756	Fidarestat ≥98%	136087-85-9	1mg	$81	2024-03-01	Buy
Cayman Chemical	21756	Fidarestat ≥98%	136087-85-9	5mg	$356	2024-03-01	Buy
Cayman Chemical	21756	Fidarestat ≥98%	136087-85-9	10mg	$632	2024-03-01	Buy
AK Scientific	V2050	Fidarestat	136087-85-9	10mg	$802	2021-12-16	Buy
American Custom Chemicals Corporation	API0002700	FIDARESTAT 95.00%	136087-85-9	100MG	$2047.5	2021-12-16	Buy

Product number	Packaging	Price	Buy
21756	1mg	$81	Buy
21756	5mg	$356	Buy
21756	10mg	$632	Buy
V2050	10mg	$802	Buy
API0002700	100MG	$2047.5	Buy

Fidarestat Chemical Properties,Uses,Production

Biological Activity

Fidarestat (SNK 860) is an aldose reductase inhibitor with IC50 values of 26 nM, 33 μM and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively. Fidarestat (SNK 860) has the potential to study diabetes.

in vitro

Fidarestat (SNK-860; 1 or 4 mg/kg. po, daily for 4 weeks) reduces the concentrations of sorbitol and fructose in diabetic rats.

in vivo

Fidarestat is an inhibitor of aldose reductase, with IC ₅₀ s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively.

target

IC50: 26 nM (Aldose reductase), 33 μM (AKR1B10), 1.8 μM (V301L AKR1B10)

Fidarestat Preparation Products And Raw materials

Raw materials

Preparation Products

Fidarestat Suppliers

Global( 56)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49391	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	info@afinechem.com	China	15377	58
CR Corporation Lomited		fred.wen@crcorporation.cn	CHINA	12069	58
Guangzhou TongYi biochemistry technology Co.,LTD	+8613073028829	mack@tongyon.com	China	2996	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33350	58

Supplier	Advantage
Hubei Jusheng Technology Co.,Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
AFINE CHEMICALS LIMITED	58
CR Corporation Lomited	58
Guangzhou TongYi biochemistry technology Co.,LTD	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58

View Lastest Price from Fidarestat manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-05	Fidarestat 136087-85-9	US $1.00 / KG	1KG	95--99%	1ton	Career Henan Chemical Co

Fidarestat
136087-85-9
US $1.00 / KG
95--99%
Career Henan Chemical Co

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Fidarestat

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(2s,4s)-6-fluoro-2',5'-dioxo-2,3-dihydrospiro[chromene-4,4'-imidazolidine]-2-carboxamide (2s,4s)-2-aminoformyl-6-fluoro-spiro[chroman-4,4'-imidazolidine]-2',5'-dione fidarestat (2S,4S)-6-FLUORO-2'',5''-DIOXOSPIRO(3,4-DIHYDRO-2H-1-BENZOPYRAN-4,4''-IMIDAZOLIDINE)-2-CARBOXAMIDE (2S,4S)-2,3-Dihydro-6-fluoro-2',5'-dioxospiro[4H-1-benzopyran-4,4'-imidazolidine]-2-carboxamide (2S,4S)-6-Fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide SNK-860 Aldos Sk 860 Spiro(4H-1-benzopyran-4,4'-imidazolidine)-2-carboxamide, 2,3-dihydro-2',5'-dioxo-6-fluoro-, (2S-cis)- Spiro(4H-1-benzopyran-4,4'-imidazolidine)-2-carboxamide, 6-fluoro-2,3-dihydro-2',5'-dioxo-, (2S-cis)- Fidarestat (SNK-860 CS-489 Spiro[4H-1-benzopyran-4,4'-imidazolidine]-2-carboxamide, 6-fluoro-2,3-dihydro-2',5'-dioxo-, (2S,4S)- FidarestatQ: What is Fidarestat Q: What is the CAS Number of Fidarestat Q: What is the storage condition of Fidarestat Q: What are the applications of Fidarestat 136087-85-9