Tacedinaline
- CAS No.
- 112522-64-2
- Chemical Name:
- Tacedinaline
- Synonyms
- acetyldinaline;CI 994;CS-617;Cl-994;Goe 5549;PD 123654;CI994, >=99%;Tacedinaline;N-Acetyldinaline;CI994 (Tacedinaline)
- CBNumber:
- CB5855542
- Molecular Formula:
- C15H15N3O2
- Molecular Weight:
- 269.3
- MDL Number:
- MFCD00866266
- MOL File:
- 112522-64-2.mol
| Melting point | 216.1 °C |
|---|---|
| Boiling point | 450.6±30.0 °C(Predicted) |
| Density | 1.322±0.06 g/cm3(Predicted) |
| RTECS | CU8702023 |
| storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
| solubility | Soluble in DMSO |
| pka | 13.15±0.70(Predicted) |
| form | powder |
| color | off-white |
| Sensitive | Air Sensitive |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| InChIKey | VAZAPHZUAVEOMC-UHFFFAOYSA-N |
| EWG's Food Scores | 1 |
| NCI Dictionary of Cancer Terms | CI-994; N-acetyldinaline |
| FDA UNII | UMF554N5FG |
| NCI Drug Dictionary | tacedinaline |
Tacedinaline price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C0621 | CI 994 ≥98% (HPLC), powder | 112522-64-2 | 5mg | $128 | 2024-03-01 | Buy |
| Sigma-Aldrich | C0621 | CI 994 ≥98% (HPLC), powder | 112522-64-2 | 25mg | $492 | 2024-03-01 | Buy |
| TCI Chemical | A2501 | 4-Acetamido-N-(2-aminophenyl)benzamide >98.0%(HPLC) | 112522-64-2 | 10mg | $66 | 2024-03-01 | Buy |
| TCI Chemical | A2501 | 4-Acetamido-N-(2-aminophenyl)benzamide >98.0%(HPLC) | 112522-64-2 | 50mg | $225 | 2024-03-01 | Buy |
| Alfa Aesar | J65561 | CI 994 | 112522-64-2 | 100mg | $207 | 2021-12-16 | Buy |
Tacedinaline Chemical Properties,Uses,Production
Description
CI-994 (112522-64-2) is an orally active histone deacetylase (HDAC) inhibitor, IC50 = 0.9, 0.9, 1.2 and >20 μM for HDAC1, HDAC2, HDAC3 and HDAC8 respectively.1 Mediates G1 cell cycle arrest, inhibits proliferation and induces apoptosis in vitro and in vivo.2,3 Increases neuroplasticity during memory extinction.4 Protects beta cells from cytokine-induced apoptosis.4
Uses
Tacedinaline is a histone deacetylase (HDAC) inhibitor. Tacedinaline is an anti-cancer agent as HDAC inhibitors block angiogenesis, arrest cell growth, and lead to differentiation and apoptosis in tumor cells. Studies show Tacedinaline to be effective against acute myeloid leukemia in vitro and in vivo when used in combination with conventional anti-cancer agents.
Definition
ChEBI: A benzamide obtained by formal condensation of the carboxy group of 4-acetamidobenzoic acid with one of the amino groups of 1,2-phenylenediamine. An oral cytostatic drug with impressive differential activity against leukemic cells and normal stem-cells. Al o used in combination therapy for selected tumors including non-smoll cell lung, pancreatic, breast, and colorectal cancers.
Biological Activity
Orally active histone deacetylase (HDAC) inhibitor (K i values are 0.41, 0.75, >100 and >100 μ M for HDAC1, HDAC3, HDAC6 and HDAC8 respectively). Mediates G 1 cell cycle arrest, inhibits proliferation and induces apoptosis in vitro and in vivo .
target
HDAC1
storage
+4°C
References
1) Moradei et al. (2007), Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity; J. Med. Chem., 50 5543 2) Beckers et al. (2007), Distinct pharmacological properties of second generation HDAC inhibitors with the benzamide or hydroxamate head group; Int. J. Cancer, 121 1138 3) Loprevite et al. (2005), In vitro study of CI-994, a histone deacetylase inhibitor, in non-small cell lung cancer cell lines; Oncol. Res., 15 39 4) Chou et al. (2012), Inhibition of histone deacetylase 3 protects beta cells from cytokine-induced apoptosis; Chem. Biol., 19 669
Tacedinaline Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10828 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 27843 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
View Lastest Price from Tacedinaline manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2019-09-04 | Tacedinaline
112522-64-2
|
US $5.00 / KG | 1KG | 99% | 1ton | Career Henan Chemical Co |
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- Tacedinaline
112522-64-2
- US $5.00 / KG
- 99%
- Career Henan Chemical Co