U-46619
- CAS No.
- 56985-40-1
- Chemical Name:
- U-46619
- Synonyms
- U-46619;U 46619,U46619;9,11-Methanoxy-PGH2;11-Methanoepoxy PGH2;9,11-Methanoepoxy PGH2;U46619, U-46619, U 46619;11α,9α-Epoxymethanoprostaglandin H2;U-46619 - CAS 56985-40-1 - Calbiochem;9,11-DIDEOXY-11ALPHA,9ALPHA-EPOXYMETHANO;4-alpha,5-beta(z),6-alpha(1e,3s*)))-r-(1-alph
- CBNumber:
- CB6437516
- Molecular Formula:
- C21H34O4
- Molecular Weight:
- 350.49
- MDL Number:
- MFCD00135238
- MOL File:
- 56985-40-1.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319-H336 | |||||||||
| Precautionary statements | P210-P305+P351+P338 | |||||||||
| Hazard Codes | F,Xi | |||||||||
| Risk Statements | 11-36-66-67 | |||||||||
| Safety Statements | 16-26 | |||||||||
| RIDADR | UN 1231 3/PG 2 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | MJ9681090 | |||||||||
| F | 8-10-23 | |||||||||
| Toxicity | LD50 intravenous in mouse: 66ug/kg | |||||||||
| NFPA 704 |
|
U-46619 price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D8174 | 9,11-Dideoxy-11α,9α-epoxymethanoprostaglandin F2α solution, 10 mg/mL in methyl acetate | 56985-40-1 | 1mg | $339 | 2024-03-01 | Buy |
| Sigma-Aldrich | 538944 | U-46619 | 56985-40-1 | 1mg | $242 | 2022-05-15 | Buy |
| Cayman Chemical | 16450 | U-46619 ≥98% | 56985-40-1 | 1mg | $97 | 2024-03-01 | Buy |
| Cayman Chemical | 16450 | U-46619 ≥98% | 56985-40-1 | 5mg | $437 | 2024-03-01 | Buy |
| Sigma-Aldrich | D8174 | 9,11-Dideoxy-11α,9α-epoxymethanoprostaglandin F2α solution, 10 mg/mL in methyl acetate | 56985-40-1 | 5mg | $1330 | 2024-03-01 | Buy |
U-46619 Chemical Properties,Uses,Production
Uses
U 46619 is a PGH2 analog that may be used as a thromboxane A2 (TP) receptor agonist affecting mitogenic growth of vascular smooth muscle in humans.
Biological Activity
PGH 2 (TXA 2 ) analog that is a potent and stable thromboxane A 2 (TP) receptor agonist (EC 50 = 0.035 μ M). Potently stimulates TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro preparations. Activates ERK-1 and ERK-2 in HEK-293 cells expressing TP α and TP β receptors.
Biochem/physiol Actions
Thromboxane receptor agonist.
in vitro
u46619 showed a biphasic effect on human platelets. shape change and mlcp occurred at low concentrations of this compound (ec50 = 0.035 um and 0.057 um), whereas serotonin release, platelet at higher concentrations (ec50 = 0.536 um and 1.31 um). the effect on platelet shape change and mlcp is receptor mediated [3].
in vivo
u46619, through activation of eta and etb receptors, elicits renal cortical vasoconstriction and medullary vasodilation in the rat [2]. in conscious shr (spontaneously hypertensive rats), 1-100 nmol/kg u-46619 (i.c.v.) induced a dose-related increase in blood pressure but had no significant effect on heart rate [1].
storage
Store at -20°C
References
[1] sirén al, svartstrm-fraser m, paakkari i. central cardiovascular effects of the endoperoxide analogue u-46619 in rats. prostaglandins leukot med. 1985 mar; 17 (3): 381-6.
[2] hantz h, adesuyi a, adebayo o. differential effects of u46619 on renal regional hemodynamics in the rat: involvement of endothelin. j pharmacol exp ther. 2001 oct; 299 (1): 372-6.
[3] morinelli ta1, niewiarowski s, daniel jl, smith jb. receptor-mediated effects of a pgh2 analogue (u 46619) on human platelets. am j physiol. 1987 nov; 253 (5 pt 2): h1035-43.
U-46619 Preparation Products And Raw materials
Raw materials
Preparation Products
U-46619 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49391 | 58 |
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| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
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| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 | sales-cpd@caerulumpharma.com | China | 3421 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |