BERTEROIN
- CAS No.
- 4430-42-6
- Chemical Name:
- BERTEROIN
- Synonyms
- KB47947;LP088984;KB-47947;OR-009512;LP-088984;BERTEROIN;1-isothiocyanato-5-(methylthio)pentane;5-(methylsulfanyl)pentyl isothiocyanate;1-isothiocyanato-5-methylsulfanylpentane;Pentane, 1-isothiocyanato-5-(methylthio)-
- CBNumber:
- CB6445272
- Molecular Formula:
- C7H13NS2
- Molecular Weight:
- 175.31
- MDL Number:
- MFCD00210791
- MOL File:
- 4430-42-6.mol
| Melting point | 155～156℃ |
|---|---|
| Boiling point | 155 °C(Press: 10 Torr) |
| Density | 1.01±0.1 g/cm3(Predicted) |
| FEMA | 4416 | 5-(METHYLTHIO)PENTYL ISOTHIOCYANATE |
| storage temp. | Store at -20°C |
| solubility | DMF: 3 mg/ml; DMSO: 16 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 10 mg/ml |
| Odor | at 0.01 % in propylene glycol. cabbage radish |
| Odor Type | radish |
| JECFA Number | 1896 |
| LogP | 2.67 |
| Substances Added to Food (formerly EAFUS) | 5-(METHYLTHIO)PENTYL ISOTHIOCYANATE |
| FDA UNII | 0L0K74BW6T |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H319 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P242-P243-P264-P280-P303+P361+P353-P305+P351+P338-P337+P313-P370+P378-P403+P235-P501 | |||||||||
| NFPA 704 |
|
BERTEROIN price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17880 | Berteroin ≥95% | 4430-42-6 | 5mg | $37 | 2024-03-01 | Buy |
| Cayman Chemical | 17880 | Berteroin ≥95% | 4430-42-6 | 10mg | $65 | 2024-03-01 | Buy |
| Cayman Chemical | 17880 | Berteroin ≥95% | 4430-42-6 | 25mg | $142 | 2024-03-01 | Buy |
| Cayman Chemical | 17880 | Berteroin ≥95% | 4430-42-6 | 50mg | $249 | 2024-03-01 | Buy |
| TRC | B318805 | Berteroin | 4430-42-6 | 500mg | $790 | 2021-12-16 | Buy |
BERTEROIN Chemical Properties,Uses,Production
Description
Berteroin is a sulforaphane analog found in cruciferous vegetables including Chinese cabbage, rucola salad leaves, and mustard oil. At 1.7 μM, it has been shown to double the phase II enzyme quinone reductase activity in mouse hepatoma cells. Berteroin exerts anti-inflammatory activity in LPS-stimulated RAW 264.7 macrophages, inhibiting degradation of IκBα, as well as NF-κB p65 translocation to the nucleus and DNA binding activity. It also suppresses IRAK degradation and phosphorylation of TAK1, p38 MAPK, ERK1/2, and Akt.
Chemical Properties
Pale yellow liquid; penetrating radish-like aroma
Occurrence
Reported found in radish and horseradish.
Uses
Berteroin is a compound with high odor potency occurring in horseradish ( Armoracia rusticana)
Definition
ChEBI: Berteroin is an isothiocyanate.
Aroma threshold values
High strength odor; recommend smelling in a 0.01% solution or less.
Enzyme inhibitor
This sulforaphane analogue and antimetastatic agent (FW = 175.43 g/mol; CAS 4430-42-6; Physical State = Liquid; Soluble in ethanol, DMSO, and chloroform; Store at -20° C; M.P. = 155-156° C), also named 5- methylthiopentyl isothiocyanate, is found in cruciferous vegetables (including Chinese cabbage and rucola leaves) and mustard oil. Berteroin inhibits LPS-induced degradation of Inhibitor of κBα (or IκBα) as well as NF-κB p65 translocation into the nucleus and DNA binding. Berteroin also suppresses degradation of IL-1 Receptor Associated Kinase and phosphorylation of Transforming Growth Factor β-Activated Kinase-1. Berteroin also inhibits LPS-induced phosphorylation of p38 MAPK, ERK1/2, and AKT
BERTEROIN Preparation Products And Raw materials
BERTEROIN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| Shanghai wencai New Material Technology Co., Ltd. | 15721586846 | wencaimat@163.com | China | 2796 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| Changzhou Furuisi Biotechnology Co., Ltd | 0519-85524369 | 3477467573@qq.com | China | 8618 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24018 | 58 |