ChemicalBook >> CAS DataBase List >>L-Canavanine
L-Canavanine
- CAS No.
- 543-38-4
- Chemical Name:
- L-Canavanine
- Synonyms
- AI352153;canavanin;AI3 52153;AI3-52153;canavanine;L-CANAVANINE;FSBIGDSBMBYOPN-VKHMYHEASA-N;(L) Canavanine,(L)Canavanine;(+)-O-(Guanidino)-L-homoserine;2-amino-4-(guanidinooxy)butyricacid
- CBNumber:
- CB6679318
- Molecular Formula:
- C5H12N4O3
- Molecular Weight:
- 176.17
- MDL Number:
- MFCD00055781
- MOL File:
- 543-38-4.mol
Last updated:2023-04-23 13:52:06
| Melting point | 184° |
|---|---|
| alpha | D20 +7.9° (c = 3.2) |
| Boiling point | 307.78°C (rough estimate) |
| Density | 1.3685 (rough estimate) |
| refractive index | 1.7900 (estimate) |
| storage temp. | 2-8°C |
| solubility | H2O: <100 mg/mL |
| form | powder |
| pka | pK1: 2.50(+2);pK2: 6.60(+1);pK3: 9.25(0) (25°C) |
| FDA UNII | 3HZV514J4B |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332 |
| Precautionary statements | P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22 |
| Safety Statements | 36 |
| WGK Germany | 3 |
| RTECS | ES7002000 |
L-Canavanine price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C1625 | L-Canavanine ≥98% (TLC), powder, from Canavalia ensiformis | 543-38-4 | 100mg | $135 | 2024-03-01 | Buy |
| Sigma-Aldrich | C1625 | L-Canavanine ≥98% (TLC), powder, from Canavalia ensiformis | 543-38-4 | 1g | $673 | 2024-03-01 | Buy |
| Sigma-Aldrich | C1625 | L-Canavanine ≥98% (TLC), powder, from Canavalia ensiformis | 543-38-4 | 250mg | $179.2 | 2024-03-01 | Buy |
| Biosynth Carbosynth | FC162286 | L-Canavanine | 543-38-4 | 100mg | $180 | 2021-12-16 | Buy |
| AK Scientific | X6876 | L-Canavanine | 543-38-4 | 250mg | $255 | 2021-12-16 | Buy |
L-Canavanine Chemical Properties,Uses,Production
Uses
NO synthase inhibitor
Definition
ChEBI: A non-proteinogenicL-alpha-amino acid that is L-homoserine substituted at oxygen with a guanidino (carbamimidamido) group. Although structurally related to L-arginine, it is non-proteinoge ic.
Biochem/physiol Actions
Canavanine is a naturally occurring L-amino acid that interferes with L-arginine-utilizing enzymes due to its structural similarity. It is a selective inhibitor of inducible nitric oxide synthase (iNOS). Overproduction of NO by iNOS plays a crucial role in the pathophysiology of septic shock and chronic inflammation.
Purification Methods
Crystallise S-canavanine from absolute EtOH or aqueous EtOH. [Tomiyama J Biol Chem 111 48 1935 gave pK9.25 (COOH), pK 7.4 (guanidinium), pK 11.5 (NH4+), Gulland & Morris J Chem Soc 763 1935,(±) Frankel et al. J Chem Soc 3127 1963, Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 pp 2622-2628 1961, Beilstein 4 III 1636, 4 IV 3188.]
L-Canavanine Preparation Products And Raw materials
Raw materials
Preparation Products
L-Canavanine Suppliers
Global( 33)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12990 | 57 | |
| Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 | sj_scrc@sinopharm.com | China | 9823 | 79 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-400-6206333 18521732826 | market@aladdin-e.com | China | 25014 | 65 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8073 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7892 | 56 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632 | sales@reading-chemicals.com | China | 15185 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Chengdu Push Bio-Technology Co., Ltd. | 028-85370565-229 18080489829 | 3004654993@qq.com | China | 9217 | 60 |
543-38-4(L-Canavanine)Related Search:
L-Homoserine, O-(aminoiminomethyl)amino-
l-α-amino-γ-(guanidinooxy)-n-butyric acid
2-amino-4-(diaminomethylideneamino)oxy-butanoic acid
L-canavanine free base from jack beans*crystallin
BUTYRICACID,2-AMINO-4-(GUANIDINOOXY)-L-
(+)-O-(Guanidino)-L-homoserine
(S)-2-Amino-4-(guanidinooxy)butyric acid
2-amino-4-(guanidinooxy)butyricacid
canavanin
canavanine
o-((aminoiminomethyl)amino)-l-homoserin
o-((aminoiminomethyl)amino)-l-homoserine
o-[(aminoiminomethyl)amino]homoserine
L-CANAVANINE
L-ALPHA-AMINO-GAMMA-[GUANIDINOOXY]-N-BUTYRIC ACID
L-CANAVANINE FREE BASE FROM JACK BEANSCR YSTALLINE
(S)-2-aMino-4-(guanidinooxy)butanoic acid
L-CANAVANINE FREE BASE FROM JACK BEA
FSBIGDSBMBYOPN-VKHMYHEASA-N
L-Canavanine >=98% (TLC), powder, from Canavalia ensiformis
AI3 52153
AI352153
AI3-52153
(L) Canavanine,(L)Canavanine
543-38-4
H2NCNHNHOCH2CH2CHNH2COOH
C5H12N4O3
BioChemical
Biochemicals and Reagents
Nitric Oxide Synthase (iNOS)
L to O
Enzyme Inhibitors
Enzyme Inhibitors by Enzyme
Enzymes, Inhibitors, and Substrates