atpenin A5
- CAS No.
- 119509-24-9
- Chemical Name:
- atpenin A5
- Synonyms
- FO 125A5;atpenin A5;Antibiotic FO 125A5;Atpenin A5 (Synthetic);(2S,4S,5R)-5,6-Dichloro-1-(2,4-dihydroxy-5,6-dimethoxypyridin-3-yl)-2,4-dimethyl-1-hexanone;(2S,4S,5R)-1-(2,4-Dihydroxy-5,6-dimethoxy-3-pyridinyl)-2,4-dimethyl-5,6-dichloro-1-hexanone;3-[(2S,4S,5R)-5,6-Dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-2(1H)-pyridinone;2(1H)-Pyridinone, 3-[(2S,4S,5R)-5,6-dichloro-2,4-dimethyl-1-oxohexyl]-4-hydroxy-5,6-dimethoxy-;preconditioning,sensitive,mKATP,Atpenin A 5,Atpenin A5,ischemia,potassium,complex II,Inhibitor,cardioprotective,channel,mitochondrial,Potassium Channel,KcsA,ATP,inhibit,reperfusion,Atpenin A-5
- CBNumber:
- CB71388223
- Molecular Formula:
- C15H21Cl2NO5
- Molecular Weight:
- 366.24
- MDL Number:
- MFCD01664873
- MOL File:
- 119509-24-9.mol
| Melting point | 83-85℃ |
|---|---|
| Boiling point | 538.3±50.0 °C(Predicted) |
| Density | 1.31±0.1 g/cm3(Predicted) |
| storage temp. | -20°C Freezer, Under inert atmosphere |
| solubility | Chlroform (Slightly), Ethanol (Slightly), Methanol (Slightly, Sonicated) |
| pka | 4.50±1.00(Predicted) |
| form | White to off-white powder. |
| color | White to Off-White |
| EWG's Food Scores | 1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| NFPA 704 |
|
atpenin A5 price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 11898 | Atpenin A5 ≥95% | 119509-24-9 | 1mg | $235 | 2024-03-01 | Buy |
| TRC | A794643 | AtpeninA5 | 119509-24-9 | 5mg | $300 | 2021-12-16 | Buy |
| Usbiological | 169935 | Atpenin A5 | 119509-24-9 | 250ug | $315 | 2021-12-16 | Buy |
| Usbiological | 044573 | Atpenin A5 | 119509-24-9 | 250ug | $368 | 2021-12-16 | Buy |
| TRC | A794643 | AtpeninA5 | 119509-24-9 | 10mg | $450 | 2021-12-16 | Buy |
atpenin A5 Chemical Properties,Uses,Production
Description
Enantioselective total synthesis of atpenin A5, a potent mitochondrial complex II (succinate-ubiquinone oxidoreductase) inhibitor, has been achieved by a convergent approach through a coupling reaction between 5-iodo-2,3,4,6-tetraalkoxypyridine and a side-chain aldehyde. The two key segments were synthesized through ortho-metalation/boronation with (MeO)3B/oxidation with mCPBA, ortho-iodination, halogen dance reaction, Sharpless epoxidation and regioselective epoxide-opening reaction.
Uses
Atpenin A5 is a mitochondrial complex II inhibitor able to protect against cardiac-reperfusion.
Definition
Atpenin A5 belongs to a class of antifungal antibiotics isolated from Penicillium sp. The atpenins are effective against filamentous fungi, particularly Trichophyton sp., and are specific and potent inhibitors of the succinate-ubiquinone reducatase activity of the mitochondrial complex II. Atpenin A5 is the most effective inhibitor against complex II from all the atpenins and has been shown to protect against cardiac-reperfusion injury in rat studies through the stimulation of mitochondrial KATP channels. Atpenin A5 is an inhibitor of SDHB, SDHC and SDHD.
Biological Activity
Mitochondrial complex II (succinate dehydrogenase or succinate:ubiquinone oxidoreductase) is a functional member of the Krebs cycle and the aerobic respiratory chain that couples the oxidation of succinate to fumarate with the reduction of quinone to quinol. Atpenin A5, an antifungal antibiotic isolated from Penicillium sp. found in soil, is a highly specific ubiquinone-binding site inhibitor of succinate dehydrogenase (IC50s = 12 and 3.7 nM in nematode and mammalian mitochondria, respectively, versus IC50s > 100 μM for inhibition of complex I and complex III enzymes). Atpenin A5 has cardioprotective effects against simulated ischemia-reperfusion injury in cardiomyocytes. Several mechanisms through which this occurs, including activation of mitochondrial ATP-sensitive potassium channels or modulation of mitochondrial reactive oxygen species generation, have been proposed.
in vitro
Highly selective, potent ubiquinone-binding site mitochondrial complex II inhibitor (IC50 values are 12 and 3.7 nM for nematode and mammalian mitochondria respectively). Stimulates mitochondrial KATP channels. Shows anti-ischemic and cardioprotective effects in vivo.
storage
+4°C
atpenin A5 Preparation Products And Raw materials
Raw materials
Preparation Products
atpenin A5 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | contact@fuxinpharm.com | China | 10297 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| Zhejiang Huida Biotech Co., LTD | 008613515763466 8615669048680 | wendy@huidabiotech.com | CHINA | 87 | 58 |
| Henan Alfa Chemical Co., Ltd | +8618339805032 | alfa4@alfachem.cn | China | 13035 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9900 | 58 |
| Supplier | Advantage |
|---|---|
| Fuxin Pharmaceutical | 58 |
| BOC Sciences | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | 58 |
| Zhejiang Huida Biotech Co., LTD | 58 |
| Henan Alfa Chemical Co., Ltd | 58 |
| Alfa Chemistry | 58 |
| TargetMol Chemicals Inc. | 58 |
| LEAPCHEM CO., LTD. | 58 |
| Aladdin Scientific | 58 |
| T&W GROUP | 58 |