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BQ-123 SODIUM SALT

BQ-123 SODIUM SALT structure

CAS No.: 136553-81-6

Chemical Name:: BQ-123 SODIUM SALT

Synonyms: ONIST;BQ-518;BQ-123;PMZ 2123;BQ-123 SODIUM SALT;BQ-123;BQ 123;BQ123;ETA-RECEPTOR ANTAGONIST;M.W. 610.70 C31H42N6O7;C(DTRP-DASP-PRO-DVAL-LEU);D-TRP-D-ASP-PRO-D-VAL-LEU

CBNumber:: CB7188725

Molecular Formula:: C31H42N6O7

Molecular Weight:: 610.7

MDL Number:: MFCD00133204

MOL File:: 136553-81-6.mol

MSDS File:: SDS

Last updated:2023-09-20 16:43:00

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BQ-123 SODIUM SALT Properties

Boiling point	1053.6±65.0 °C(Predicted)
Density	1.33±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble to 0.40 mg/ml in sterile
form	lyophilized powder
pka	4.04±0.10(Predicted)
Water Solubility	Soluble in water (0.4 mg/ml)
FDA UNII	S2A8YZM151

SAFETY

Risk and Safety Statements

Safety Statements	22-24/25
WGK Germany	3

BQ-123 SODIUM SALT price More Price(40)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	B150	BQ-123 ≥99%, sodium salt, lyophilized powder	136553-81-6	200μg	$155	2024-03-01	Buy
Sigma-Aldrich	B150	BQ-123 ≥99%, sodium salt, lyophilized powder	136553-81-6	1mg	$172.4	2024-03-01	Buy
Sigma-Aldrich	05-23-3831	BQ-123, Sodium Salt A highly potent, selective, and competitive ETA (endothelin) receptor antagonist (Ki = 40 nM for ETA versus Ki = 2.5 μM for ETB).		1MG	$195	2024-03-01	Buy
Sigma-Aldrich	05-23-3831	BQ-123, Sodium Salt A highly potent, selective, and competitive ETA (endothelin) receptor antagonist (Ki = 40 nM for ETA versus Ki = 2.5 μM for ETB).		5MG	$789	2023-06-20	Buy
Alfa Aesar	J66169	BQ-123	136553-81-6	0.5mg	$75.9	2023-06-20	Buy

Product number	Packaging	Price	Buy
B150	200μg	$155	Buy
B150	1mg	$172.4	Buy
05-23-3831	1MG	$195	Buy
05-23-3831	5MG	$789	Buy
J66169	0.5mg	$75.9	Buy

BQ-123 SODIUM SALT Chemical Properties,Uses,Production

Uses

BQ-123 has been used as a selective endothelin-A receptor antagonist to study its effects on tumor necrosis factor α (TNFα)-induced human airway smooth muscle cells (HASMCs) proliferation. It is also used as endothelin-A receptor antagonist to study its effects on TNFα-induced granulocyte–macrophage colony-stimulating factor (GM-CSF) expression.

Definition

ChEBI: BQ 123 is a cyclic peptide.

Biological Activity

bq-123 is a potent and selective antagonist of eta endothelin receptor with ki values of 1.4 and 1500 nm for eta and etb receptors, respectively.endothelin receptor is a g protein-coupled receptor. eta receptor increases intracellular-free ca2+. also, activation of eta receptor increases vasoconstriction and blood pressure.bq-123 is a selective eta receptor antagonist. in the eta-expressing cells, bq123 (10-6 m) inhibited endothelin-1 (et-1) (10-6 m)-induced [ca2+]i increase by 95% [1]. in rat vascular smooth muscle cells (vsmc), bq-123 inhibited et-1 receptor binding, cellular contraction, [ca2+ ]i mobilization, [3h]thymidine incorporation, map kinase activation and mtt reduction induced by et-1. however, bq-123 didn’t inhibit angiotensin ii (ang ii)- and arginine vasopressin (avp)-induced increases in map kinase activity and [ca2+]i mobilization [2].in spontaneously hypertensive rats (shr), renin hypertensive rats and normotensive rats, bq-123 (16 nm/kg/min) reduced mean arterial pressure in a dose-dependent way in shr. also, bq-123 lowered blood pressure in both renin hypertensive rats and normotensive rats [3]. in a kidney transplantation rat model with reperfusion injury, bq-123 prevented reperfusion injury and inhibited the synthesis and release of et-1,2 [4].

Biochem/physiol Actions

Selective ETA endothelin receptor antagonist.

storage

-20°C

References

[1]. sakamoto a, yanagisawa m, sawamura t, et al. distinct subdomains of human endothelin receptors determine their selectivity to endothelina-selective antagonist and endothelinb-selective agonists. j biol chem, 1993, 268(12): 8547-8553.
[2]. guo x, okada k, fujita n, et al. inhibitory effect of bq-123 on endothelin-1-stimulated mitogen-activated protein kinase and cell growth of rat vascular smooth muscle cells. hypertens res, 1996, 19(1): 23-30.
[3]. douglas sa, gellai m, ezekiel m, et al. bq-123, a selective endothelin subtype a-receptor antagonist, lowers blood pressure in different rat models of hypertension. j hypertens, 1994, 12(5): 561-567.
[4]. büyükgebiz o, aktan ao, haklar g, et al. bq-123, a specific endothelin (eta) receptor antagonist, prevents ischemia-reperfusion injury in kidney transplantation. transpl int, 1996, 9(3): 201-207.

BQ-123 SODIUM SALT Preparation Products And Raw materials

Raw materials

Preparation Products

BQ-123 SODIUM SALT Suppliers

Global( 136)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Alpha Biopharmaceuticals Co., Ltd	+86-411-39042497 +8613921981412	sales@alphabiopharm.com	China	886	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21687	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32715	60
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10247	58
Cellmano Biotech Limited	0551-65326643 18156095617	info@cellmano.com	China	999	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49391	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
BOC Sciences	16314854226; +16314854226	inquiry@bocsci.com	United States	19743	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58

Supplier	Advantage
Alpha Biopharmaceuticals Co., Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Shenzhen Nexconn Pharmatechs Ltd	58
Cellmano Biotech Limited	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
BOC Sciences	58
Zhejiang J&C Biological Technology Co.,Limited	58

View Lastest Price from BQ-123 SODIUM SALT manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-02-14	BQ-123 SODIUM SALT 136553-81-6	US $7.00 / KG	1KG	99%	100kg	Career Henan Chemical Co

BQ-123 SODIUM SALT
136553-81-6
US $7.00 / KG
99%
Career Henan Chemical Co

BQ-123 SODIUM SALT Spectrum

BQ-123 SODIUM SALT(136553-81-6)¹HNMR

136553-81-6(BQ-123 SODIUM SALT)Related Search:

BQ-123 SODIUM SALT JKC-301 [3H]BQ 123 C(DILE-LEU-DTRP-DASP-PRO)

M.W. 610.70 C31H42N6O7 BQ-518 Cyclo(D-Asp-L-Pro-D-Val-L-Leu-D-Trp-) Cyclo(D-Trp-D-Asp-L-Pro-D-Val-L-Leu-) Cyclo[D-Asp-L-Pro-D-Val-L-Leu-D-Trp-] BQ-123 SYNTHETIC >99% SELECTIVE ETA ENDO THE cyclo(Trp-Asp-Pro-Val-Leu) BQ-123 BQ-123 SODIUM SALT ETA-RECEPTOR ANTAGONIST C(DTRP-DASP-PRO-DVAL-LEU) CYCLO (D-ALPHA-ASPARTYL-L-PROLYL-D-VALYL-L-LEUCYL-D-TRYPTOPHYL) CYCLO(D-ASP-PRO-D-VAL-LEU-D-TRP) CYCLO(D-ASP-PRO-D-VAL-LEU-DTRP NA) CYCLO(-D-TRP-D-ASP-PRO-D-VAL-LEU) CYCLO (-D-TRP-D-ASP-PRO-D-VAL-LEU) SODIUM SALT D-TRP-D-ASP-PRO-D-VAL-LEU BQ-123;BQ 123;BQ123 2-[(3R,6R,9S,12R,15S)-6-(1H-indol-3-ylmethyl)-9-(2-methylpropyl)-2,5,8,11,14-pentaoxo-12-propan-2-yl-1,4,7,10,13-pentazabicyclo[13.3.0]octadecan-3-yl]acetic acid PMZ 2123 Cyclo(D-α-aspartyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl) BQ-123 >=99%, sodium salt, lyophilized powder Cyclo(D-α-aspartyl-L-prolyl-D-valyl-L-leucyl-D-tryptophyl 2-((3R,6S,9R,12R,17aS)-9-((1H-indol-3-yl)methyl)-6-isobutyl-3-isopropyl-1,4,7,10,13-pentaoxohexadecahydro-1H-pyrrolo[1,2-a][1,4,7,10,13]pentaazacyclopentadecin-12-yl)acetic acid 136553-81-6 BQ-123 SODIUM SALT ONIST ETA-Receptor Antagonist [BQ-123] sodium salt inhibit,blood,Endothelin Receptor,artery,BQ-123,pressure,muscle,smooth,cells,BQ 123,Inhibitor,pulmonary 136553-81-6 C31H42N6O7 Endothelins Peptides Antagonists Amino Acids and Peptides Biochemicals and Reagents BioChemical Antagonists Endothelins Peptides for Cell Biology Endothelin receptor