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2,5-Dichloronitrobenzene

CAS No.
89-61-2
Chemical Name:
2,5-Dichloronitrobenzene
Synonyms
1,4-DICHLORO-2-NITROBENZENE;2.5-Dichloroni;2,5-Dichlornitrobenzol;2,5-Dichlornitrobenzen;NITRO-P-DICHLOROBENZENE;2,5-DICHLORONITROBENZOL;2,5-dichlornitrobenzene;Domperidone Impurity 10;2,5-DICHLORONITROBENZENE;2-NITRO-P-DICHLOROBENZENE
CBNumber:
CB7854600
Molecular Formula:
C6H3Cl2NO2
Molecular Weight:
192
MDL Number:
MFCD00007074
MOL File:
89-61-2.mol
Last updated:2023-10-20 16:46:35

2,5-Dichloronitrobenzene Properties

Melting point 52-54 °C(lit.)
Boiling point 267 °C
Density 1,442 g/cm3
vapor density 6.6 (vs air)
vapor pressure <0.1 mm Hg ( 25 °C)
refractive index 1.4390 (estimate)
Flash point >230 °F
storage temp. Store below +30°C.
solubility 0.083g/l
color Pale Yellow
explosive limit 2.4-8.5%(V)
Water Solubility Soluble in water, ethanol, ether, benzene, carbon disulfide. Slightly soluble in carbon tetrachloride.
BRN 778109
LogP 2.87 at 25℃
CAS DataBase Reference 89-61-2(CAS DataBase Reference)
FDA UNII IY18G50FF4
Proposition 65 List 1,4-Dichloro-2-Nitrobenzene
IARC 2B (Vol. 65, 123) 2020
NIST Chemistry Reference Benzene, 1,4-dichloro-2-nitro-(89-61-2)
EPA Substance Registry System 2,5-Dichloronitrobenzene (89-61-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS09
Signal word  Warning
Hazard statements  H302-H411
Precautionary statements  P273-P301+P312+P330
Hazard Codes  Xn,N
Risk Statements  22-36-51/53
Safety Statements  26-60
RIDADR  UN 3077 9/PG 3
WGK Germany  2
RTECS  CZ5260000
TSCA  Yes
HazardClass  9
PackingGroup  III
HS Code  29049085
NFPA 704
1
1 0

2,5-Dichloronitrobenzene Chemical Properties,Uses,Production

Chemical Properties

yellow flakes

Uses

2,5-Dichloronitrobenzene is a reagent used in the synthesis of antitrypanosomal, antileishmanial and antimalarial agents. Also it is used in the synthesis of lysophosphatidic acid acyltransferase-β inhibitors.

Production Methods

Nitration of 1,4-dichlorobenzene with mixed acid at 35 – 65 ℃ results in a 98 % yield of essentially pure 2,5-Dichloronitrobenzene.

Purification Methods

Crystallise the nitrobenzene from absolute EtOH. [Beilstein 5 IV 726.]

106-46-7
89-61-2
Synthesis of 2,5-Dichloronitrobenzene from 1,4-Dichlorobenzene
Benzene, 2,5-dichloronitro- Benzene,1,4-dichloro-2-nitro- Benzene,1-nitro-2,5-dichloro NITRO-P-DICHLOROBENZENE 2-NITRO-1,4-DICHLOROBENZENE 2-NITRO-P-DICHLOROBENZENE 2,5-DICHLORO-1-NITROBENZENE 2,5-DICHLORONITROBENZENE 1,4-dichloro-nitrobenzene 2 5-DICHLORONITROBENZENE 99% (GC) 2,5-DICHLORONITROBENZENE PESTANAL, 250 M 2,5-DICHLORONITROBENZOL 1,4-Dichlor-2-nitrobenzol 2,5-dichlornitrobenzene 2,5-Dichloronitrobenzene,99% 1,4-Dichloro-2-nitrobenzene,2,5-Dichloronitrobenzene, Nitro-p-dichlorobenzene 2.5-Dichloronitrobenzene 250mg [89-61-2] 2,5-Dichloronitrobenzene, 99% 5GR 1,4-DICHLORO-2-NITROBENZENE FOR SYNTHESI 2,5-two chloronitrobenzene 2.5-Dichloroni 2,5-Dichlornitrobenzol 2,5-DICHLORO-4-NITROBENZENE 2,5-DICHLORONITROBENZENE pure 2,5-Dichloronitrobenzene, Nitro-p-dichlorobenzene 1,4-dichloro-2-nitro-benzen 1-Nitro-2,5-dichlorobenzene 2,5-Dichlornitrobenzen 2,5-dichloronitrobenezene 1,4-Dichloro-2-nitrobenzene Solution 1,4-Dichloro-2-nitrobenzene > 1,4-Dichloro-2-nitrobenzene,98% 4-Dichloro-2-nitrobenzene 1,4-DICHLORO-2-NITROBENZENE Domperidone Impurity 10 89-61-2 NO2C6H3Cl2 Building Blocks Organic Building Blocks Nitrogen Compounds Nitro Compounds Aromatic Halides (substituted) Benzene derivates Dyestuff Intermediates Intermediates of Dyes and Pigments