ChemicalBook >> CAS DataBase List >>NU7026
NU7026
- CAS No.
- 154447-35-5
- Chemical Name:
- NU7026
- Synonyms
- CS-595;LY 293646;NU7026, >=98%;NU 7026; NU-7026;NU7026 USP/EP/BP;NU7026;LY293646; NU-7026;DNA-PK Inhibitor II NU7026 NU-7026;2-MORPHOLINO-4H-BENZO[H]CHROMEN-4-ONE;2-(4-Morpholinyl)-4H-naphtho[1,2-b]pyran-4-one;2-(4-Morpholinyl)-4H-naphthol[1,2-b]pyran-4-one
- CBNumber:
- CB8503981
- Molecular Formula:
- C17H15NO3
- Molecular Weight:
- 281.31
- MDL Number:
- MFCD06798345
- MOL File:
- 154447-35-5.mol
- MSDS File:
- SDS
Last updated:2023-06-30 15:45:59
| Melting point | 267-269 °C(Solv: methanol (67-56-1); water (7732-18-5)) |
|---|---|
| Boiling point | 459.9±45.0 °C(Predicted) |
| Density | 1.330 |
| storage temp. | 2-8°C |
| solubility | DMSO: 3 mg/mL at 60 °C, soluble |
| form | solid |
| pka | 0.49±0.20(Predicted) |
| color | tan |
| FDA UNII | DJ7RQT66H6 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|---|---|
| Signal word | Danger |
| Hazard statements | H314 |
| Precautionary statements | P501-P264-P280-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P405 |
| WGK Germany | 3 |
NU7026 price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | N1537 | NU7026 ≥98% (HPLC), solid | 154447-35-5 | 5mg | $279 | 2024-03-01 | Buy |
| Sigma-Aldrich | 260961 | DNA-PK Inhibitor II | 154447-35-5 | 5mg | $245 | 2024-03-01 | Buy |
| Cayman Chemical | 13308 | NU 7026 ≥95% | 154447-35-5 | 5mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 13308 | NU 7026 ≥95% | 154447-35-5 | 10mg | $152 | 2024-03-01 | Buy |
| Cayman Chemical | 13308 | NU 7026 ≥95% | 154447-35-5 | 25mg | $356 | 2024-03-01 | Buy |
NU7026 Chemical Properties,Uses,Production
Uses
DNA-PK Inhibitor II is an antiproliferative agent, and inhibitor of DNA-PK.
Uses
NU7026 has been used:
- as a DNA-dependent protein kinase (DNA-PK) inhibitor, to pre-treat colon cancer cell
- in kinase inhibitor experiments for treating zygotes with visible pronuclei post 20 h-human chorionic gonadotropin (hCG)
- to determine its influence on cytotoxicity of dibenzo[def,p]chrysene on HepG2 cells
Definition
ChEBI: 2-(4-morpholinyl)-4-benzo[h][1]benzopyranone is an organooxygen compound and an organic heterotricyclic compound.
Biological Activity
ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK). Displays selectivity over other PIKK family enzymes (IC 50 values are 0.23, 13.0, > 100 and > 100 μ M for DNA-PK, PI3K, ATM and ATR respectively). Radiosensitizes both proliferating and quiescent mouse embryonic fibroblast cells to IR and inhibits DSB repair.
Biochem/physiol Actions
Cell permeable, small molecule benzochromenone inhibitor of DNA-PK (DNA dependent protein kinase).
storage
Store at +4°C
NU7026 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 106)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32686 | 60 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 27945 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Young Lively PharminBlock Co.,Ltd | +undefined18600731423 | jason_gao@yl-pharminblock.com | China | 1944 | 58 |
154447-35-5(NU7026)Related Search:
2-MORPHOLINO-4H-BENZO[H]CHROMEN-4-ONE
NU7026, >=98%
2-(4-Morpholinyl)-4H-naphthol[1,2-b]pyran-4-one
NU7026;LY293646; NU-7026
LY 293646
2-(4-Morpholinyl)-4H-naphtho[1,2-b]pyran-4-one
4H-Naphtho[1,2-b]pyran-4-one, 2-(4-morpholinyl)-
2-(4-Morpholinyl)-4H-naphtho[1,2-b]pyran-4-one NU7026
DNA-PK Inhibitor II - CAS 154447-35-5 - Calbiochem
NU 7026; NU-7026
CS-595
NU7026 USP/EP/BP
DNA-PK Inhibitor II NU7026 NU-7026
DNA-dependent protein kinase,inhibit,NU-7026,Apoptosis,DNA-PK,LY-293646,Inhibitor,LY 293646,NU 7026
154447-35-5
Inhibitors