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2-Picolylamine

2-Picolylamine structure

CAS No.: 3731-51-9

Chemical Name:: 2-Picolylamine

Synonyms: pyridin-2-ylmethanamine;2-(AMINOMETHYL)PYRIDINE;DI-(2-PICOLYL)AMINE;C-PYRIDIN-2-YL-METHYLAMINE;2-Picolyamine;2-pyridinemethanamine;(2-Pyridylmethyl)amine;2AMPY;2-Picolinamine;2-PICOLYLAMINE

CBNumber:: CB8853569

Molecular Formula:: C6H8N2

Molecular Weight:: 108.14

MDL Number:: MFCD00006360

MOL File:: 3731-51-9.mol

MSDS File:: SDS

Last updated:2023-11-10 16:48:32

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2-Picolylamine Properties

Melting point	20°C
Boiling point	82-85 °C12 mm Hg(lit.)
Density	1.049 g/mL at 25 °C(lit.)
refractive index	n20/D 1.578(lit.)
Flash point	194 °F
storage temp.	Keep in dark place,Inert atmosphere,2-8°C
form	Liquid
pka	pK1: 2.31(+2);pK2: 8.79(+1) (25°C,μ=0.5)
color	Clear colorless to yellow or orange
PH	11-12 (100g/l, H2O, 20℃)
Water Solubility	SOLUBLE
Sensitive	Air Sensitive
BRN	108054
CAS DataBase Reference	3731-51-9(CAS DataBase Reference)
FDA UNII	XK7252M2PA
NIST Chemistry Reference	2-Pyridinemethanamine(3731-51-9)
EPA Substance Registry System	2-Pyridinemethanamine (3731-51-9)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05

Signal word

Danger

Hazard statements

H314

Precautionary statements

P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363-P405

Hazard Codes

C,Xi

Risk Statements

36/37/38-34-37

Safety Statements

26-36/37/39-45-25-36-27

RIDADR

UN 2735 8/PG 2

WGK Germany

RTECS

US1840000

Hazard Note

Corrosive

TSCA

Yes

HazardClass

PackingGroup

III

HS Code

29333999

NFPA 704

	2
3		0

2-Picolylamine price More Price(44)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	65562	2-Picolylamine for HPLC derivatization, ≥98.0% (GC)	3731-51-9	1ml	$33.3	2022-05-15	Buy
TCI Chemical	A1161	2-Picolylamine >98.0%(GC)(T)	3731-51-9	25g	$37	2024-03-01	Buy
TCI Chemical	A1161	2-Picolylamine >98.0%(GC)(T)	3731-51-9	250g	$208	2024-03-01	Buy
Alfa Aesar	B23208	2-(Aminomethyl)pyridine, 98+%	3731-51-9	5g	$26.65	2024-03-01	Buy
Alfa Aesar	B23208	2-(Aminomethyl)pyridine, 98+%	3731-51-9	25g	$69.65	2024-03-01	Buy

Product number	Packaging	Price	Buy
65562	1ml	$33.3	Buy
A1161	25g	$37	Buy
A1161	250g	$208	Buy
B23208	5g	$26.65	Buy
B23208	25g	$69.65	Buy

2-Picolylamine Chemical Properties,Uses,Production

Description

It is usually used as the intermediate or raw material in the organic synthesis and pharmaceutical synthesis. For example, this chemical can promote the Al(OTf)3-catalyzed aminolysis of 1,2-epoxides to produce β-Amino alcohols N-2'-pyridylmethyl in excellent yields.¹ Moreover, this substance may function as the raw material to produce copper(Ⅱ) complexes with sulfonamides that act as the active chemical nucleases.² In addition, by using this chemical as substrate, an efficient [2+3] cycloaddition approach has been developed for the synthesis of pyridyl-appended fullerene ligands.³ Besides, 2-picolylamine is chosen as the recognition group to get better selectivity for a rhodamine-based “turn-on” fluorescent probe for Fe3+ in aqueous solution.⁴

Reference

Fringuelli, F.; Pizzo, F.; Tortoioli, S.; Vaccaro, L., Solvent-free Al(OTf)(3)-catalyzed aminolysis of 1,2-epoxides by 2-picolylamine: A key step in the synthesis of ionic liquids. J. Org. Chem. 2004, 69, 7745-7747.
Macias, B.; Villa, M. V.; Salgado, M.; Borras, J.; Gonzalez-Alvarez, M.; Sanz, F., Copper(II) complexes with sulfonamides derived from 2-picolylamine and their use as chemical nucleases. Inorg. Chim. Acta 2006, 359, 1465-1472.
Troshin, P. A.; Peregudov, A. S.; Muhlbacher, D.; Lyubovskaya, R. N., An efficient 2+3 cycloaddition approach to the synthesis of pyridyl-appended fullerene ligands. Eur. J. Org. Chem. 2005, 3064-3074.
Ji, S. Z.; Meng, X. M.; Ye, W. P.; Feng, Y.; Sheng, H. T.; Cai, Y. L.; Liu, J. S.; Zhu, X. F.; Guo, Q. X., A rhodamine-based "turn-on" fluorescent probe for Fe3+ in aqueous solution. Dalton Trans. 2014, 43, 1583-1588.

Chemical Properties

clear colorless to yellow or orange liquid

Uses

2-Picolylamine may be used as a derivatization agent to enhance the sensitivity of carboxylic acids and short-chain fatty acids for their determination in biological samples by liquid chromatography coupled to electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) and ultra-high performance liquid chromatography (UHPLC), respectively.

Uses

2-Picolylamine is a bihaptic amine that can be used:

As a key precursor to synthesize various ionic liquids through the formation of β-amino alcohols as intermediates.
As a chelating ligand for the synthesis of complexes such as zinc picolylamine complex and Cu(II) picolylamine complex.
To functionalize poly(styrene-co-maleic anhydride) (PSMA) resin to facilitate the adsorption of uranium from aqueous solution.

Definition

ChEBI: 2-Pyridinemethanamine is a member of pyridines.

General Description

2-Picolylamine, a bihaptic nucleophile, is a bidentate ligand that is generally utilized for the preparation of various multidentate ligands and the corresponding complexes.

2-Picolylamine synthesis

Synthesis of 2-Picolylamine from 2-Cyanopyridine

2-Picolylamine Preparation Products And Raw materials

Raw materials

4-Cyanopyridine Ammonium hydroxide NICKEL ALUMINIDE Nickel Sodium bicarbonate

Acetic acid 2-Cyanopyridine 2-Acetylaminomethyl pyridine 2-Pyridinemethanamine, N-(2-pyridinylmethylene)- syn-2-pyridinealdoxime

N-(2-PYRIDINYLMETHYL)UREA 2-(azidomethyl)pyridine(SALTDATA: FREE) Benzophenone

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Preparation Products

Flecainide TETRA-2-PYRIDINYLPYRAZINE 1,2-Ethanediamine, N,N-bis(2-pyridinylmethyl)- 2-PIPERIDYLMETHYLAMINE 2,2'-DIPICOLYLAMINE

2-Picolylamine Suppliers

Global( 400)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Terma Medicare India Pvt.,Ltd	+8613916485955	shivshanghai@yahoo.com	India	135	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12471	58
Hebei Yanxi Chemical Co., Ltd.	+8617531190177	peter@yan-xi.com	China	6000	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	18229	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15957	58
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21689	55
Jiangsu Qingquan Chemical Co., Ltd.	+86-571-86589381,86589382,86589383	sales1@qqpharm.com	CHINA	154	55
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58

Supplier	Advantage
Terma Medicare India Pvt.,Ltd	58
Hebei Mojin Biotechnology Co., Ltd	58
Hebei Yanxi Chemical Co., Ltd.	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Henan Tianfu Chemical Co.,Ltd.	55
Jiangsu Qingquan Chemical Co., Ltd.	55
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58

View Lastest Price from 2-Picolylamine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-01-11	2-Picolylamine 3731-51-9	US $122.00-1.00 / KG	1KG	99%	g-kg-tons, free sample is available	Henan Fengda Chemical Co., Ltd
2023-11-11	2-Picolylamine 3731-51-9	US $0.00 / KG	1KG	99%	50000KG/month	Hebei Mojin Biotechnology Co., Ltd
2023-09-23	2-Picolylamine 3731-51-9	US $25.00-3.00 / kg	1kg	0.99	20 tons	Hebei Yanxi Chemical Co., Ltd.

2-Picolylamine
3731-51-9
US $122.00-1.00 / KG
99%
Henan Fengda Chemical Co., Ltd

2-Picolylamine
3731-51-9
US $0.00 / KG
99%
Hebei Mojin Biotechnology Co., Ltd

2-Picolylamine
3731-51-9
US $25.00-3.00 / kg
0.99
Hebei Yanxi Chemical Co., Ltd.

2-Picolylamine Spectrum

2-Picolylamine(3731-51-9)MS 2-Picolylamine(3731-51-9)¹HNMR 2-Picolylamine(3731-51-9)¹³CNMR 2-Picolylamine(3731-51-9)IR1 2-Picolylamine(3731-51-9)Raman

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2-(Aminobenzyl)pyridine 2-aminomethyl-pyridin 2-Picolinamine Pyridine-2-methanamine 2-(Aminomethyl)pyridine ,98% 2-Picolylamine,2-(Aminomethyl)pyridine 2-(AMinoMethyl)pyridine, 99% 25ML 2-(AMINOMETHYL)PYRIDINE FOR SYNTHESIS Picolinylamine, (Pyridin-2-yl)methylamine (An Jiaji2-)pyridine 2-PicolylaMine 99% 2 - Methyl pyridine aMMonia 2-Pyridinemethylamine 2-Pyridinylmethanamine beta-Picolylamine Pyridine, 2-(aminomethyl)- PICOLYLAMINE (BIS-2-) RARECHEM AH CK 0022 TIMTEC-BB SBB004352 ALPHA,ALPHA'-IMINODI(2-PICOLINE) AKOS BBS-00003681 2-pyridinemethaneamine 2-PICOLYLAMINE BIS-2-PICOLYLAMINE 2,2'-DIPICOLYLAMINE 2,2'-BIS(PYRIDYLMETHYL)AMINE 2AMPY 2-(AMINOMETHYL)PYRIDINE,2-PICOLYLAMINE 2-(Aminomethyl)pyridine,99% 1-pyridin-2-ylmethanamine 2-AMINOMETHYL PYRIDINE C-PYRIDIN-2-YL-METHYLAMINE 2-pyridinylmethylammonium 2-Picolylamine > 2-(Aminomethyl)pyridine, 99%, for synthesis 2-Pyridylmethylamin 2 - piperidine amine 2-Picolylamine ISO 9001：2015 REACH (2-Pyridylmethyl)amine 2-pyridinemethanamine C-PYRIDIN-2-YL-METHYLAMINE DI-(2-PICOLYL)AMINE 2-(AMINOMETHYL)PYRIDINE 2-Picolyamine pyridin-2-ylmethanamine 3731-51-9 98 1824-81-3 AMINE C6 C9 to C46 Building Blocks Pyridines Heterocyclic Building Blocks Heterocycle-Pyridine series Pyridines derivates Amines bc0001