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INDEX NAME NOT YET ASSIGNED

INDEX NAME NOT YET ASSIGNED Structure
INDEX NAME NOT YET ASSIGNED structure
CAS No.
2719051-84-8
Chemical Name:
INDEX NAME NOT YET ASSIGNED
Synonyms
CBNumber:
CB911554052
Molecular Formula:
C79H98Cl2N14O13S3
Molecular Weight:
1618.81
MDL Number:
MOL File:
Mol file
Last updated:2023-06-30 15:45:59
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INDEX NAME NOT YET ASSIGNED Properties

Density 1.39±0.1 g/cm3(Predicted)
solubility Soluble to 50 mM in DMSO
pka 13.52±0.46(Predicted)

INDEX NAME NOT YET ASSIGNED Chemical Properties,Uses,Production

Biological Activity

SIM1 is a potent and selective trivalent PROTAC? Degrader based on BET bromodomain inhibitors linked to a Von Hippel Lindau (VHL) ligand via branched linkers. SIM1 degrades all BET family proteins with a preference for BRD2 (DC50 values = 0.7 nM, 1.1 nM and 3.3 nM for BRD4, BRD2 and BRD3, respectively). SIM1 degrades BRD2 more significantly and rapidly than BRD3 and BRD4, and degrades BET proteins with a higher potency than a bivalent degrader. SIM1 also decreases protein levels for Myc and HMOX1 and induces apoptosis in prostate cancer cells.

storage

Store at -20°C

INDEX NAME NOT YET ASSIGNED Preparation Products And Raw materials

Raw materials

Preparation Products

INDEX NAME NOT YET ASSIGNED Suppliers

Global( 1)Suppliers
Supplier Tel Email Country ProdList Advantage
Jilin Chinese Academy of Sciences-yanshen Technology 18143011203 ET-market@chemextension.com China 40893 58
Supplier Advantage
Jilin Chinese Academy of Sciences-yanshen Technology 58
2719051-84-8