viridicatumtoxin
- CAS No.
- 39277-41-3
- Chemical Name:
- viridicatumtoxin
- Synonyms
- NSC 159628;viridicatumtoxin;Spiro[2-cyclohexene-1,2'(1'H)-cyclopenta[de]naphthacene]-9'-carboxamide, 7',7'a,8',11',11'a,12'-hexahydro-5',6',7'a,10',11'a,12'-hexahydroxy-3'-methoxy-2,6,6-trimethyl-7',8'-dioxo-, (1R,7'aR,11'aR,12'R)-rel-(-)-
- CBNumber:
- CB91382922
- Molecular Formula:
- C30H31NO10
- Molecular Weight:
- 565.57
- MDL Number:
- MFCD01675248
- MOL File:
- 39277-41-3.mol
- MSDS File:
- SDS
| Melting point | 235°C (rough estimate) |
|---|---|
| Boiling point | 630.75°C (rough estimate) |
| Density | 1.3203 (rough estimate) |
| refractive index | 1.6310 (estimate) |
| storage temp. | Store at -20°C |
| solubility | DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble |
| form | A solid |
| EWG's Food Scores | 1 |
| FDA UNII | S8N62PLU21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501 | |||||||||
| NFPA 704 |
|
viridicatumtoxin price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 25480 | Viridicatumtoxin ≥98% | 39277-41-3 | 1mg | $227 | 2024-03-01 | Buy |
| Cayman Chemical | 25480 | Viridicatumtoxin ≥98% | 39277-41-3 | 5mg | $954 | 2024-03-01 | Buy |
| TRC | V673905 | Viridicatumtoxin | 39277-41-3 | 1mg | $230 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | BIO0000728 | VIRIDICATUMTOXIN 95.00% | 39277-41-3 | 5MG | $504.9 | 2021-12-16 | Buy |
| AK Scientific | 2060DM | Viridicatumtoxin | 39277-41-3 | 5mg | $1161 | 2021-12-16 | Buy |
viridicatumtoxin Chemical Properties,Uses,Production
Description
Viridicatumtoxin in a mycotoxin originally isolated from Penicillium that has diverse biological activities, including antimicrobial, cytotoxic, and toxic properties. It inhibits the growth of B. subtilis, M. luteus, C. perfringens, B. fragilis, and methicillin-resistant S. aureus (MRSA; MICs = 0.39-1.56 μg/ml), as well as C. albicans, S. cerevisiae, M. racemosus, A. niger, and P. chrysogenum (MICs = 6.2-25 μg/ml), but has no activity against M. smegmatis, E. coli, K. pneumoniae, P. aeruginosa, or S. marcescens (MICs = >100 μg/ml). Viridicatumtoxin inhibits the production of polyprenyl alcohols by S. aureus undecaprenyl pyrophosphate (UPP) synthase, E. coli octaprenyl pyrophosphate synthase (OPS), and S. cerevisiae dehydrodolichyl pyrophosphate (DedoIPP) synthase in vitro (IC50s = 3.1, 21, and 71 μM, respectively). It has cytotoxic effects against human Jurkat T (IC50 = 4.92 μM), chronic lymphocytic leukemia (CLL; LC50 = 0.7-3.5 nM), and bone marrow-derived HS-5 stromal cells. Viridicatumtoxin is toxic to rats and mice when administered intraperitoneally (LD50s = 80 and 90 mg/kg, respectively) and to rats when administered via gastric intubation (LD50 = 122.4 mg/kg), but not to rats or mice when administered orally or through subcutaneous injection.
Uses
Viridicatumtoxin is a tetracycline-like metabolite produced by several species of Penicillium, first isolated in 1976 as a mycotoxin. Initial testing revealed that viridicatumtoxin caused myocardial deterioration, renal tubule necrosis and spleen atrophy. Analogous to the related tetracyclines, viridicatumtoxin was found to be a potent antibacterial, with activity against S. aureus including MRSA and QRSA strains. Little has been published on the mode of action of viridicatumtoxin.
Uses
Viridicatumtoxin is a tetracycline-like metabolite produced by several species of Penicillium.
Definition
ChEBI: A tetracycline-like polyketide antibiotic that is produced by several species of Penicillium and Aspergillus.
viridicatumtoxin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| BOC Sciences | +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Lynnchem | 86-(0)29-85992781 17792393971 | info@lynnchem.com | China | 4587 | 58 |
| Novachemistry | 44-20819178-90 02081917890 | info@novachemistry.com | United Kingdom | 4381 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55936 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Meng Cheng Technology (Shanghai) Co., LTD | 400-820-6829 | sales@mitachieve.com | China | 8864 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing1@energy-chemical.com | China | 44843 | 58 |
39277-41-3(viridicatumtoxin)Related Search:
1of4