ChemicalBook >> CAS DataBase List >>XL413 (BMS-863233)
XL413 (BMS-863233)
- CAS No.
- 1169562-71-3
- Chemical Name:
- XL413 (BMS-863233)
- Synonyms
- CS-1062;XL413.HCL;BMS-863233 HCl;XL413(BMS-863233);BMS-863233 HCl salt;BMS-863233 (XL-413);XL413 (hydrochloride);XL413 (BMS-863233) HCl;BMS-863233 HCl (XL-413);BMS-863233 Hydrochloride
- CBNumber:
- CB92627547
- Molecular Formula:
- C14H13Cl2N3O2
- Molecular Weight:
- 326.18
- MDL Number:
- MFCD28023577
- MOL File:
- 1169562-71-3.mol
- MSDS File:
- SDS
Last updated:2023-06-30 15:45:59
| storage temp. | -20°C |
|---|---|
| solubility | DMSO: Insoluble;Ethanol: Insoluble |
| form | powder |
| color | white to beige |
| Water Solubility | Water: 46 mg/mL (141.03 mM) |
| Stability | Hygroscopic |
| FDA UNII | JG305JRH1Z |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301 |
| Precautionary statements | P301+P310+P330 |
| RIDADR | UN 2811 6.1 / PGIII |
XL413 (BMS-863233) price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1401 | XL413 hydrochloride ≥98% (HPLC) | 1169562-71-3 | 5mg | $201 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1401 | XL413 hydrochloride ≥98% (HPLC) | 1169562-71-3 | 25mg | $663 | 2024-03-01 | Buy |
| Tocris | 5493 | XL413 hydrochloride ≥99%(HPLC) | 1169562-71-3 | 50 | $952 | 2021-12-16 | Buy |
| Tocris | 5493 | XL413 hydrochloride ≥99%(HPLC) | 1169562-71-3 | 10 | $227 | 2021-12-16 | Buy |
| TRC | X746230 | XL413 | 1169562-71-3 | 5mg | $135 | 2021-12-16 | Buy |
XL413 (BMS-863233) Chemical Properties,Uses,Production
Uses
XL413 is a potent and selective cell division cycle 7 homolog (CDC7) kinase inhibitor.
Biological Activity
XL413 hydrochloride is a potent and selective cell division cycle 7 homolog (CDC7) kinase inhibitor with IC50 of 3.4 nM, its selectivity over CK2, Pim-1 and pMCM2 are 63-, 12- and 35-fold. Phase 1/2.
in vitro
In MDA-MB-231T and Colo-205 cell lines,XL413 hydrochloride inhibits CDC7-specific phosphorylation of MCM2. XL413 also inhibited cell proliferation in Colo-205 cells, decreased cell viability, and stimulated caspase 3/7 activity. Furthermore, XL413 resulted in altered S-phase progression and subsequent apoptosis.
in vivo
In the Colo-205 xenograft model, XL413, at a dose of 3 mg/kg, inhibited 70% of phosphorylated MCM2 and caused significant regression of tumor growth at a dose of 100 mg/kg.
target
| Target | Value |
| Cdc7 (Cell-free assay) | 3.4 nM |
| Pim1 (Cell-free assay) | 42 nM |
| 212 nM |
storage
Store at -20°C
XL413 (BMS-863233) Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 83)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
| career henan chemical co | +86-0371-86658258 15093356674; | factory@coreychem.com | China | 29826 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 27792 | 58 |
| Chemia Biotechnology（Shanghai） Co., Ltd | +8613816753574 | info@chemia-pharm.com | CHINA | 311 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10523 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
View Lastest Price from XL413 (BMS-863233) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2020-01-14 | XL413 (BMS-863233)
1169562-71-3
|
US $9.80 / KG | 1g | ≥99% | 100kg | Career Henan Chemical Co |
-
- XL413 (BMS-863233)
1169562-71-3
- US $9.80 / KG
- ≥99%
- Career Henan Chemical Co
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Benzofuro[3,2-d]pyriMidin-4(3H)-one, 8-chloro-2-(2S)-2-pyrrolidinyl-, (Hydrochloride) (1:)
XL413 (hydrochloride)
BMS-863233 (XL-413)
8-Chloro-2-(2S)-2-pyrrolidinylbenzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride (1:?)
XL413(BMS-863233)
BMS-863233 HCl
Benzofuro[3,2-d]pyrimidin-4(3H)-one, 8-chloro-2-(2S)-2-pyrrolidinyl-, hydrochloride
BMS-863233 HCl salt
XL413.HCL
BMS-863233 HCl (XL-413)
(4AR,6S,7R,7AS)-6-[4-[[(1S)-2,3-DIHYDRO-1H-INDEN-1-YL]AMINO]PYRROLO[2,3-D]PYRIMIDIN-7-YL]-2-(4-METHOXYPHENYL)-4,4A,5,6,7,7A-HEXAHYDROCYCLOPENTA[D][1,3]DIOXIN-7-OL
8-Chloro-2-(2S)-2-pyrrolidinylbenzofuro[3,2-d]pyrimidin-4(3H)-one hydrochloride
CS-1062
XL 413 hydrochloride - BMS 863233 hydrochloride
BMS-863233; BMS863233; BMS 863233; XL-413; XL413; XL 413.
BMS-863233 Hydrochloride
XL413 (BMS-863233) USP/EP/BP
XL413 (BMS-863233) HCl
(S)-8-Chloro-2-(pyrrolidin-2-yl)benzofuro[3,2-d]pyrimidin-4(3H)-one xhydrochloride
1169562-71-3
C14H12ClN3O2xHCl
Inhibitors
API