ChemicalBook >> CAS DataBase List >>TCO-PEG4-NHS ester
TCO-PEG4-NHS ester
- CAS No.
- 1613439-69-2
- Chemical Name:
- TCO-PEG4-NHS ester
- Synonyms
- TCO-PEG4-NHS ester;(4E)-TCO-PEG4-NHS ester;2,5-Dioxopyrrolidin-1-yl 1-(cyclooct-4-en-1-yloxy)-1-oxo-5,8,11,14-tetraoxa-2-azaheptadecan-17-oate;(Z)-2,5-dioxopyrrolidin-1-yl 1-(cyclooct-4-en-1-yloxy)-1-oxo-5,8,11,14-tetraoxa-2-azaheptadecan-17-oate;5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1-(4-cycloocten-1-yl) 17-(2,5-dioxo-1-pyrrolidinyl) ester
- CBNumber:
- CB93062671
- Molecular Formula:
- C24H38N2O10
- Molecular Weight:
- 514.57
- MDL Number:
- MFCD28118912
- MOL File:
- 1613439-69-2.mol
Last updated:2024-04-03 12:01:48
| Density | 1.23±0.1 g/cm3(Predicted) |
|---|---|
| solubility | Soluble in DMSO, DCM, DMF |
| pka | 11.95±0.46(Predicted) |
| InChI | InChI=1S/C24H38N2O10/c27-21-8-9-22(28)26(21)36-23(29)10-12-31-14-16-33-18-19-34-17-15-32-13-11-25-24(30)35-20-6-4-2-1-3-5-7-20/h1-2,20H,3-19H2,(H,25,30)/b2-1- |
| InChIKey | ZKPMRASGLDBKPF-UPHRSURJSA-N |
| SMILES | C(OC1CCCC=CCC1)(=O)NCCOCCOCCOCCOCCC(ON1C(=O)CCC1=O)=O |c:6| |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
TCO-PEG4-NHS ester price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| BroadPharm | BP-22418 | TCO-PEG4-NHSester 95% | 1613439-69-2 | 10mg | $139 | 2021-12-16 | Buy |
| BroadPharm | BP-22418 | TCO-PEG4-NHSester 95% | 1613439-69-2 | 25mg | $235 | 2021-12-16 | Buy |
| BroadPharm | BP-22418 | TCO-PEG4-NHSester 95% | 1613439-69-2 | 100mg | $575 | 2021-12-16 | Buy |
TCO-PEG4-NHS ester Chemical Properties,Uses,Production
Description
TCO-PEG4-NHS Ester is a click chemistry crosslinker. This reagent can be used to label antibodies, proteins and other primary amine containing molecule. The hydrophilic PEG spacer increases water-solubility and decreases steric hindrance during ligation. TCO enable fast click chemistry under mild condition
Biological Activity
TCO-PEG4-NHS ester is a PROTAC linker and belongs to the PEG class,it can be used to synthesize a series of PROTAC molecules.It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Cleavable
| PEGs
|
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Xian confluore Biological Technology Co., Ltd. | +86-15680926068 +86-15680926068 | 1924344760@confluore.cn | China | 2893 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 | sales@huarongpharm.com | CHINA | 3149 | 58 |
| Shanghai Huici Pharmaceutical Technology Co., LTD | +8618917134367 | lixing@pharmahuici.com | China | 133 | 58 |
| Shanghai Huici Pharmaceutical Technology Co., LTD | +8618917134367 | lixing@pharmahuici.com | China | 133 | 58 |
| Jilin Chinese Academy of Sciences-yanshen Technology | +undefined18143011203 | info@chemextension.com | China | 42057 | 58 |
| Xi'an Confluore Biological Technology Co., Ltd. | +86-156-80926068 +86-15680926068 | 1924344760@qq.com | China | 4955 | 58 |
| Borenpharm Co., Ltd | 027-65563561 | sales@borenpharm.com | China | 1246 | 55 |
| Jinan elephant international trading co., LTD | 13006575422@163.com | China | 6357 | 58 |
View Lastest Price from TCO-PEG4-NHS ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-03-21 | (4E)-TCO-PEG4-NHS ester
1613439-69-2
|
US $0.00 / mg | 50mg | >95.00% | 50mg | Xian confluore Biological Technology Co., Ltd. |
-
- (4E)-TCO-PEG4-NHS ester
1613439-69-2
- US $0.00 / mg
- >95.00%
- Xian confluore Biological Technology Co., Ltd.
1613439-69-2(TCO-PEG4-NHS ester)Related Search:
TCO-PEG4-NHS ester
(4E)-TCO-PEG4-NHS ester
5,8,11,14-Tetraoxa-2-azaheptadecanedioic acid, 1-(4-cycloocten-1-yl) 17-(2,5-dioxo-1-pyrrolidinyl) ester
(Z)-2,5-dioxopyrrolidin-1-yl 1-(cyclooct-4-en-1-yloxy)-1-oxo-5,8,11,14-tetraoxa-2-azaheptadecan-17-oate
2,5-Dioxopyrrolidin-1-yl 1-(cyclooct-4-en-1-yloxy)-1-oxo-5,8,11,14-tetraoxa-2-azaheptadecan-17-oate
1613439-69-2