SPARSOMYCIN
- CAS No.
- 1404-64-4
- Chemical Name:
- SPARSOMYCIN
- Synonyms
- U-19183;nsc59729;Aids012106;B 120121L19;Aids-012106;sparsomycin;Sparsomycin from Streptomyces sparsogenes;(E)-N-[(S)-1-(Hydroxymethyl)-2-[[(methylthio)methyl]sulfinyl]ethyl]-3-(1,2,3,4-tetrahydro-6-methyl-2,4-dioxopyrimidine-5-yl)propenamide;2-Propenamide, N-[(1S)-1-(hydroxymethyl)-2-[(R)-[(methylthio)methyl]sulfinyl]ethyl]-3-(1,2,3,4-tetrahydro-6-methyl-2,4-dioxo-5-pyrimidinyl)-, (2E)-
- CBNumber:
- CB9497025
- Molecular Formula:
- C13H19N3O5S2
- Molecular Weight:
- 361.44
- MDL Number:
- MFCD01684112
- MOL File:
- 1404-64-4.mol
- MSDS File:
- SDS
| Melting point | 208-209° (dec) |
|---|---|
| alpha | D25 +69° (c = 0.5 in water) |
| Density | 1.3893 (rough estimate) |
| refractive index | 1.6390 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble |
| form | A solid |
| pka | 8.67 in water, 9.05 in 40% ethanol |
| EWG's Food Scores | 1 |
| FDA UNII | 6C940P63E7 |
SAFETY
Risk and Safety Statements
| Hazard Codes | T+ |
|---|---|
| Risk Statements | 28 |
| Safety Statements | 28-36/37-45 |
| RIDADR | UN 2811 6.1/PG 2 |
| RTECS | WG5850000 |
| Toxicity | LD50 in dogs, rats, mice (mg/kg): 0.5-1.0, 2.25, 4.32 i.v. (Ottenheijm, 1986); LD50 i.p. in mice: 2.4 mg/kg (Owen) |
SPARSOMYCIN price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29934 | Sparsomycin | 1404-64-4 | 1mg | $189 | 2024-03-01 | Buy |
| Cayman Chemical | 29934 | Sparsomycin | 1404-64-4 | 5mg | $755 | 2024-03-01 | Buy |
| American Custom Chemicals Corporation | API0015533 | SPARSOMYCIN 95.00% | 1404-64-4 | 5MG | $500.41 | 2021-12-16 | Buy |
SPARSOMYCIN Chemical Properties,Uses,Production
Description
Sparsomycin is a bacterial metabolite and a nucleoside analog of uracil that has been found in S. sparsogenes and has diverse biological activities. It is active against KB carcinoma cells, Gram-positive and Gram-negative bacteria, and fungi. Sparsomycin is an inhibitor of peptidyl transferase that interferes with tRNA binding to the A-site of the peptidyl transfer center and increases the binding of peptidyl-tRNA to the P-site. It inhibits protein synthesis in bacteria, archaea, and eukaryotes. Sparsomycin reduces tumor growth in a P388 mouse leukemia model and in a Walker 256 carcinosarcoma rat model.
Uses
Research tool for studying protein biosynthesis.
Uses
Sparsomycin is an antibiotic that binds to active site and exit tunnel hydrophobic crevices of peptidyltransferase center of Haloarcula marismortui large ribosomal subunit.
SPARSOMYCIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19743 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 50002 | 58 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Meng Cheng Technology (Shanghai) Co., LTD | 400-820-6829 | sales@mitachieve.com | China | 8864 | 58 |
| Hubei Enxing Biotechnology Co., Ltd | 16621771607 | exbio_tech@163.com | China | 8344 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 8740 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 18112977050 | cb5@aikonchem.com | China | 10529 | 58 |