aminometradine
- CAS No.
- 642-44-4
- Chemical Name:
- aminometradine
- Synonyms
- Mictine;Catapyrin;BRN 0175533;Aminometramide;aminometradine;1-allyl-6-amino-3-ethyl-pyrimidine-2,4-quinone;6-amino-3-ethyl-1-prop-2-enylpyrimidine-2,4-dione;6-azanyl-3-ethyl-1-prop-2-enyl-pyrimidine-2,4-dione;2,4(1H,3H)-Pyrimidinedione, 6-amino-3-ethyl-1-(2-propen-1-yl)-
- CBNumber:
- CB9920323
- Molecular Formula:
- C9H13N3O2
- Molecular Weight:
- 195.221
- MDL Number:
- MFCD00086227
- MOL File:
- 642-44-4.mol
| Melting point | 75-115°; mp 143-144° |
|---|---|
| Boiling point | 331.89°C (rough estimate) |
| Density | 1.1985 (rough estimate) |
| refractive index | 1.5100 (estimate) |
| FDA UNII | PPM8SX5Q3V |
aminometradine price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PH006926 | 1-allyl-6-amino-3-ethyl-2,4(1H,3H)-pyrimidinedione AldrichCPR | 642-44-4 | 25MG | $134 | 2023-06-20 | Buy |
| TRC | M344720 | Mictine | 642-44-4 | 25mg | $160 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 47738 | Mictine | 642-44-4 | 25mg | $650 | 2021-12-16 | Buy |
| Medical Isotopes, Inc. | 47738 | Mictine | 642-44-4 | 250mg | $2200 | 2021-12-16 | Buy |
aminometradine Chemical Properties,Uses,Production
Originator
Mincard,Searle,US,1954
Uses
Mictine is an oral diuretic that is used in the management of edema and in the treatment of congestive heart failure.
Definition
ChEBI: Aminometradine is a pyrimidone.
Manufacturing Process
85 parts of monoallylurea are dissolved in 105 parts of acetic anhydride, and
85 parts of cyanoacetic acid are added gradually and the mixture is
maintained at 65°C for 2.5 hours. The mixture is distilled at 20 mm until a
syrup remains. 50 parts of water are added to this syrup and distillation is
resumed. The resulting syrup is dissolved in 96% ethanol at 60°C, stirred with
charcoal and filtered. One to one and one-half volumes of ether are added to
the filtrate at 40°C. Upon cooling the N-cyanoacetyl-N'-allylurea precipitates.
It is collected on a filter and washed with ether. The white crystals melt at
about 142-143°C. The N-cyanoacetyl-N'-allylurea is dissolved by warming with
10% sodium hydroxide. Sufficient 70% sodium hydroxide is added to raise the
pH to 10. The solution is maintained at 60°C for five minutes. After cooling
the crystals are collected on a filter and recrystallized from water. 1-Allyl-6-
amino-1,2,3,4-tetrahydro-2,4-pyrimidinedione is obtained in the form of white
crystals melting at 270-272°C.
334 parts of 1-allyl-6-amino-1,2,3,4-tetrahydro-2,4-pyrirnidinedione are
dissolved in a solution of 88 parts of sodium hydroxide in 1,100 parts of
water. While this mixture is stirred rapidly at 50°C, 430 parts of diethyl sulfate
are added in the course of 30 minutes. Stirring is continued at 50-55°C for
one hour longer, and an alkaline reaction is maintained by occasional additions
of small portions of 20% aqueous sodium hydroxide solution, about 300 parts
in all being required. On cooling, the 1-allyl-3-ethyl-6-amino-1,2,3,4-
tetrahydro-2,4-pyrimidinedione separates as the monohydrate; it is filtered
off, washed with cold water, and recrystallized from water containing a small
amount of sodium hydroxide to hold in solution any unreacted 1-allyl-6-
amino-1,2,3,4-tetrahydro-2,4-pyrimidinedione. The air dried product thus
obtained contains 1 mol of crystal water and melts over a wide range with
dehydration at 75-115°C. After dehydration by treatment with anhydrous
ether, the anhydrous 1-allyl-3-ethyl-6-amino-1,2,3,4-tetrahydro-2,4-
pyrimidinedione melts sharply at about 143-144°C.
Therapeutic Function
Diuretic
aminometradine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 13028896684 | sales@rrkchem.com | China | 55936 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44941 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24018 | 58 |
| Supplier | Advantage |
|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 58 |
| TargetMol Chemicals Inc. | 58 |
| J & K SCIENTIFIC LTD. | 76 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | 58 |
| Energy Chemical | 58 |
| TargetMol Chemicals Inc. | 58 |
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