3a,4,7,7a-テトラヒドロ-5-(ヒドロキシフェニル-2-ピリジニルメチル)-8-(フェニル-2-ピリジニルメチレン)-4,7-メタノ-1H-イソインドール-1,3(2H)-ジオン 化学特性,用途語,生産方法
説明
Norbormide was first introduced on the market in 1964 as
a selective raticide, but does not have a current registration for
commercial use in the European Union or North America.
Current use as a pesticide is minimal to nonexistent worldwide.
This compound’s toxicity is highly specific for rats.
化学的特性
White solid. Insoluble in
water; soluble in dilute acids.
使用
Norbormide is used as a rodenticide. It acts as a vasoconstrictor and calcium channel blocker, but is selectively toxic to rats and has relatively low toxicity to other species, due to a species specific action of opening the permeability transition pores in rat mitochondria.
定義
A rodenticide specific for rats,
supposedly nontoxic to other animals or to humans
.
一般的な説明
Colorless to off-white crystalline powder. Used as a selective rat poison.
反応プロフィール
When heated to decomposition, NORBORMIDE emits toxic fumes of nitrogen oxides. Avoid alkalis. [EPA, 1998].
危険性
Toxic by ingestion.
健康ハザード
Moderately to highly toxic to humans. Probable human lethal dose is 50 to 500 mg/kg, or 1 teaspoon to 1 pint for a 150 lb. person.
火災危険
When heated to decomposition, NORBORMIDE emits toxic fumes of nitrogen oxides. Avoid alkalies.
安全性プロファイル
Poison by ingestion andintravenous routes. A rodenticide. When heated todecomposition it emits toxic fumes of NOx.
職業ばく露
This material is used as a selective,
fast acting rat poison.
環境運命予測
Because of its use as a rodenticide, norbormide may have
entered the environment, particularly as a soil contaminant.
The vapor pressure for norbormide is estimated to be
4.3 ×10
-22 mmHg at 25 ℃, while Henry’s constant is
2.7 × 10
-23 atmm
3 mol
-1. Therefore, volatilization from wet
or dry soil is not likely to occur. If present in contaminated soil,
norbormide may be transported in the air and undergo wet or
dry deposition. Also, with a Koc of 2000, there would be some
minor soil mobility. The high Koc coupled with a bioconcentration
factor (BCF) of 290 predicts that norbormide
contaminating aquatic systems would adsorb to suspended
solids or sediments and would bioconcentrate.
輸送方法
UN2588 Pesticides, solid, toxic, Hazard Class:
6.1; Labels: 6.1-Poisonous materials, Technical Name
Required.
不和合性
Compounds of the carboxyl group react
with all bases, both inorganic and organic (i.e., amines)
releasing substantial heat, water and a salt that may be
harmful. Incompatible with arsenic compounds (releases
hydrogen cyanide gas), diazo compounds, dithiocarbamates,
isocyanates, mercaptans, nitrides, and sulfides
(releasing heat, toxic and possibly flammable gases), thiosulfates
and dithionites (releasing hydrogen sulfate and
oxides of sulfur).
廃棄物の処理
Small amounts may be treated
with alkali, then landfilled. Large amounts should be incinerated
. In accordance with 40CFR165, follow recommendations
for the disposal of pesticides and pesticide
containers. Must be disposed properly by following package
label directions or by contacting your local or federal
environmental control agency, or by contacting your
regional EPA office.
3a,4,7,7a-テトラヒドロ-5-(ヒドロキシフェニル-2-ピリジニルメチル)-8-(フェニル-2-ピリジニルメチレン)-4,7-メタノ-1H-イソインドール-1,3(2H)-ジオン 上流と下流の製品情報
原材料
準備製品