エトドラク 化学特性,用途語,生産方法
外観
白色～わずかにうすい黄色, 結晶性粉末～粉末
溶解性
メタノール及びエタノール(99.5)に溶けやすく、水にほとんど溶けない。
用途
ピラノ酢酸系化合物です。シ
クロオキシゲナーゼ2（COX-2）を選択的に
阻害します。
用途
インドール酢酸系化合物です。シクロオキシゲナーゼ-IIを選択的に阻害する作用を示します。
効能
鎮痛薬, 抗炎症薬, シクロオキシゲナーゼ2阻害薬
商品名
オステラック (あすか製薬); ハイペン (日本新薬)
説明
Etodolac (etodolic acid) is a non-steroidal antiinflammatory/analgesic agent
useful in the treatment of various inflammatory conditions, including rheumatoid
and osteoarthritis.
化学的特性
Crystalline Solid
使用
Etodolac is a non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits cyclooxygenase-2 (COX-2). Etodolac displays anti-inflammatory effects in both adjuvant arthritic and normal rats. E
todolac is an anti-inflammatory; analgesic.
定義
ChEBI: A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is substituted by a 1,8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl moiety. A preferential inhibitor of cyclo-oxygenase 2 and non-steroidal anti-inflammatory,
it is used for the treatment of rheumatoid arthritis and osteoarthritis, and for the alleviation of postoperative pain. Administered as the racemate, only the (S)-enantiomer is active.
適応症
Etodolac (Lodine) is indicated for the treatment of
osteoarthritis, rheumatoid arthritis, and acute pain. It inhibits
COX-2 with slightly more selectivity than COX-1
and therefore produces less GI toxicity than many other
NSAIDs. Common adverse effects include skin rashes
and CNS effects.
一般的な説明
Etodolac (Lodine, Ultradol), a chiral, COX-2 selectiveNSAID drug that is marketed as a racemate, possesses an indolering as the aryl portion of this group of NSAID drugs.It shares many similar properties of this group and is indicatedfor short- and long-term management of pain and OA.
Similar to ketorolac, etodolac exhibits several uniqueenantioselective pharmacokinetic properties. For example,the “inactive” (R)-enantiomer has approximately a 10-foldhigher plasma concentration than the active (S)-enantiomer.Furthermore, the active (S)-enantiomer is less protein boundthan its (R)-enantiomer and therefore has a very large volumeof distribution. It is well absorbed with an elimination halflifeof 6 to 8 hours. Etodolac is extensively metabolized intothree major inactive metabolites, 6-hydroxy etodolac (via aromatichydroxylation), 7-hydroxy-etodolac (via aromatic hydroxylation),and 8-(1'-hydroxylethyl) etodolac (via benzylichydroxylation), which are eliminated as the correspondingether glucuronides. Its unstable, acyl glucuronide, however,is subject to enterohepatic circulation and reactivation tothe parent drug, similar to other NSAIDS in this class.
生物活性
Non-steroidal anti-inflammatory drug (NSAID) that selectively inhibits cyclooxygenase-2 (COX-2) (IC 50 values are 53 and >100 μ M for COX-2 and COX-1 respectively). Displays anti-inflammatory effects in both adjuvant arthritic and normal rats.
作用機序
The primary mechanism of action appears to be
inhibition of the biosynthesis of prostaglandins at the cyclooxygenase step, with no inhibition of the lipoxygenase
system. Etodolac, however, possesses a more favorable ratio of inhibition of prostaglandin biosynthesis in human
rheumatoid synoviocytes and chondrocytes than by cultured human gastric mucosal cells compared to ibuprofen,
indomethacin, naproxen, diclofenac, and piroxicam.
薬物動態学
Etodolac is rapidly absorbed following oral administration, with maximum serum levels being achieved within 1 to 2
hours, and it is highly bound to plasma proteins (99%) with pKa 4.7. The penetration of etodolac into synovial fluid is
greater than or equal to that of tolmetin, piroxicam, or ibuprofen. Only diclofenac appears to provide greater
penetration.
臨床応用
Etodolac is promoted as the first of a new chemical class of anti-inflammatory drugs, the pyranocarboxylic acids.
Although not strictly an arylacetic acid derivative (because there is a two-carbon atom separation between the
carboxylic acid function and the hetero-aromatic ring), it still possesses structural characteristics similar
to those of the heteroarylacetic acids and is classified here. It was introduced in the United States in 1991 for acute
and long-term use in the management of osteoarthritis and as an analgetic. It also possesses antipyretic activity.
Etodolac is marketed as a racemic mixture, although only the S-(+)-enantiomer possesses anti-inflammatory activity
in animal models. Etodolac also displays a high degree of enantioselectivity in its inhibitory effects on the
arachidonic acid cyclooxygenase system.
代謝
Etodolac is metabolized to three hydroxylated metabolites and to glucuronide conjugates, none of which
possesses important pharmacological activity. Metabolism appears to be the same in the elderly as in the general
population, so no dosage adjustment appears necessary.
Etodolac is indicated for the management of the signs and symptoms of osteoarthritis and for the management of
pain.
エトドラク 上流と下流の製品情報
原材料
準備製品