SU11274
SU11274 物理性質
- 比重(密度) :
- 1.401±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- DMSO：10mg/mL、60℃
- 酸解離定数(Pka):
- 11.62±0.20(Predicted)
- 外見 :
- 粉
- 色:
- オレンジ
- InChIKey:
- FPYJSJDOHRDAMT-KQWNVCNZSA-N
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01BVI1938-5 |
SU 11274 |
658084-23-2 |
5mg |
￥37700 |
2020-09-21 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01BVI1938-25 |
SU 11274 |
658084-23-2 |
25mg |
￥146900 |
2020-09-21 |
購入 |
|
Sigma-Aldrich Japan
|
S9820 |
≥98% (HPLC), powder
SU 11274 ≥98% (HPLC), powder |
658084-23-2 |
25mg |
￥162400 |
2021-03-23 |
購入 |
|
Sigma-Aldrich Japan
|
S9820 |
≥98% (HPLC), powder
SU 11274 ≥98% (HPLC), powder |
658084-23-2 |
5mg |
￥50500 |
2018-12-25 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01W0119-1712 |
SU11274 |
658084-23-2 |
5mg |
￥37700 |
2020-09-21 |
購入 |
SU11274 化学特性,用途語,生産方法
溶解性
In vitro (25℃) DMSO 92 mg/mL (161.94 mM)
説明
MET is a proto-
oncogene which encodes the hepatocyte growth factor receptor c-
Met. It has normal roles in morphogenesis, migration, apoptosis, and angiogenesis. Dysregulation of c-
Met occurs in many types of cancer. SU11274 is a potent, selective, ATP-competitive inhibitor of c-Met (IC
50 = 20 nM). It has much less or no activity against other receptor tyrosine kinases. SU11274 induces apoptosis and cell cycle arrest in transformed Ba/F3 cells and cancer cell lines.
使用
SU 11274 is a competitive inhibitor of Met kinase activity.
Biochem/physiol Actions
SU 11274 is a class I c-Met inhibitor that competes with ATP to bind to the activation loop of c-Met.1 Inhibition of c-Met by SU 11274 is effective in improving the clinical outcome in non-small cell lung cancer cell lines.2
SU11274 上流と下流の製品情報
原材料
準備製品
SU11274 生産企業
Global( 123)Suppliers
658084-23-2(SU11274)キーワード:
- 658084-23-2
- PKI-SU11274
- N-(3-Chlorophenyl)-N-methyl-3-[[3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl]methylene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide
- N-(3-Chlorophenyl)-N-methyl-3-[[3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl]methylene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide SU11274
- SU 11274, >=98%
- Met Kinase Inhibitor
- (Z)-N-(3-Chlorophenyl)-3-((3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrol-2-yl)methy
- (3z)-n-(3-chlorophenyl)-3-({3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1h-pyrrol-2-yl}methylene)-n-methyl-2-oxo-2,3-dihydro-1h-indole-5-sulfonamide
- SU 11274，SU 11274
- (Z)-N-(3-chlorophenyl)-3-((3,5-diMethyl-4-(4-Methylpiperazine-1-carbonyl)-1H-pyrrol-2-yl)Methylene)-N-Methyl-2-oxoindoline-5-sulfonaMide
- SU11274(PKI-SU11274)
- Sul1274
- (Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-(1-methylpiperazine-4-carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxoindoline-5-sulfonamide
- (3Z)-N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrol-2-yl]methylidene]-N-methyl-2-oxo-1H-indole-5-sulfonamide
- (3Z)-N-(3-Chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-1H-indole-5-sulfonamide
- Met Kinase Inhibitor - CAS 658084-23-2 - Calbiochem
- SU-11274;PKI-SU11274;SU 11274
- SU 11274 USP/EP/BP
- 1H-Indole-5-sulfonamide, N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-[(4-methyl-1-piperazinyl)carbonyl]-1H-pyrrol-2-yl]methylene]-2,3-dihydro-N-methyl-2-oxo-, (3Z)-
- Met Kinase Inhibitor SU11274 SU-11274
- SU 11274,Inhibitor,Autophagy,inhibit,c-Met/HGFR,Apoptosis,SU-11274,SU11274
- SU11274