(4S)-4-ヒドロキシ-L-イソロイシン
(4S)-4-ヒドロキシ-L-イソロイシン 物理性質
- 融点 :
- 223-224℃
- 沸点 :
- 331.6±32.0 °C(Predicted)
- 比重(密度) :
- 1.181±0.06 g/cm3 (20 ºC 760 Torr)
- 闪点 :
- 147℃
- 貯蔵温度 :
- Keep in dark place,Inert atmosphere,2-8°C
- 溶解性:
- メタノール（微量）、水（微量）
- 酸解離定数(Pka):
- 2.41±0.25(Predicted)
- 外見 :
- 個体
- 色:
- ホワイトからオフホワイト
- 光学活性 (optical activity):
- [α]/D +32.5±2.0°, c = 1 in H2O
- BRN :
- 4128096
- InChI:
- InChI=1S/C6H13NO3/c1-3(4(2)8)5(7)6(9)10/h3-5,8H,7H2,1-2H3,(H,9,10)/t3-,4-,5-/m0/s1
- InChIKey:
- OSCCDBFHNMXNME-YUPRTTJUSA-N
- SMILES:
- C(O)(=O)[C@@H](N)[C@@H](C)[C@H](C)O
(4S)-4-ヒドロキシ-L-イソロイシン 価格
もっと(8)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01CHDASB-00008504 |
Hydroxyisoleucine, 4- |
55399-93-4 |
5mg |
￥46400 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01CHDASB-00008504 |
Hydroxyisoleucine, 4- |
55399-93-4 |
10mg |
￥84600 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
50118 |
(4S)-4-ヒドロキシ-L-イソロイシン from fenugreek seed, ≥98.0% (TLC)
(4S)-4-Hydroxy-L-isoleucine from fenugreek seed, ≥98.0% (TLC) |
55399-93-4 |
50mg |
￥67100 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQC-4092 |
4-Hydroxy-l-isoleucine |
55399-93-4 |
1g |
￥37500 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01CHDASB-00008504 |
Hydroxyisoleucine, 4- |
55399-93-4 |
50mg |
￥305600 |
2024-03-01 |
購入 |
(4S)-4-ヒドロキシ-L-イソロイシン 化学特性,用途語,生産方法
説明
4-Hydroxyisoleucine is an amino acid that has been found in fenugreek (
T. foenum graecum) seeds and has antidiabetic activity. It increases glucose-stimulated insulin release from isolated rat islets and isolated perfused rat pancreas when used at a concentration of 200 μM.
In vivo, 4-hydroxyisoleucine increases PI3K activity in muscle and liver in rats when administered at a dose of 18 mg/kg and in muscle in a rat model of type 2 diabetes induced by nicotinamide and streptozotocin (STZ; ) when administered at 25 mg/kg. 4-Hydroxyisoleucine (50 mg/kg per day for four weeks) decreases plasma glucose, triglyceride, LDL, HDL, and cholesterol levels in an STZ-induced rat model of type 1 diabetes.
天然物の起源
4-hydroxyisoleucine has been extracted and purified from fenugreek seeds, which are known in traditional medicine for their antidiabetic properties.
使用
(4S)-4-Hydroxy-L-isoleucine is 4S isomer of 4-Hydroxyisoleucine, which is used as a treatment for type II diabetes.
定義
ChEBI: An L-isoleucine derivative that is L-isoleucine bearing a (4S)-hydroxy substituent.
生物活性
4-Hydroxyisoleucine increases glucose-induced insulin release, in the concentration range of 100 micromol/l to 1 mmol/l, through a direct effect on isolated islets of Langerhans from both rats and humans.
(4S)-4-ヒドロキシ-L-イソロイシン 上流と下流の製品情報
原材料
準備製品
(4S)-4-ヒドロキシ-L-イソロイシン 生産企業
Global( 184)Suppliers
55399-93-4((4S)-4-ヒドロキシ-L-イソロイシン)キーワード:
- 55399-93-4
- 4-HYDROXYISOLEUCINE; 4-HYDROXY-L-ISOLEUCINE
- HIL
- HYDROXYISOLEUCINE, 4-
- 2-AMINO-2,3,5-TRIDEOXY-3-METHYL-D-XYLONIC ACID
- (2S,3R,4S)-4-HYDROXYISOLEUCINE MAJOR ISOMER AND (2R,3R,4S)-4-HYDROXYISOLEUCINE MINOR ISOMER
- [DISCONTINUED] Replaced by KIT-00008502-0HK
- HYDROXYISOLEUCINE, 4-(FG)
- (2S,3R,4S)-2-Amino-4-hydroxy-3-methylpentanoic acid
- (4S)-4-Hydroxy-L-isoleucine
- L-Ribonic acid, 2-amino-2,3,5-trideoxy-3-methyl-
- (4S)-4-Hydroxy-L-isoleucine from fenugreek seed, >=98.0% (TLC)
- 4-HYDROXYISOLEUCINECAS:55399-93-4
- TIANFU-CHEM 4-HYDROXYISOLEUCINE
- 4 -Hydroxyisoleucic acid
- Hydroxyisoleucine 55399-93-4
- (4S)-4-ヒドロキシ-L-イソロイシン