N,N-ビス(2-クロロエチル)-2-ナフチルアミン 化学特性,用途語,生産方法
用途
抗悪性腫瘍薬(白血病とホジキン病の治療において使われる)
化学的特性
Chlornaphazine is composed of clear, colorless plates or may be a brown solid.
世界保健機関（WHO）
The World Health Organization has no information further to the
above regarding preparations containing chlornaphazine or to indicate that they
are still commercially manufactured.
一般的な説明
Colorless plates or brown solid.
空気と水の反応
Insoluble in water.
反応プロフィール
chlornaphazine reacts with nucleophiles .
火災危険
Flash point data are not available for chlornaphazine , but chlornaphazine is probably combustible.
安全性プロファイル
Confirmed human carcinogenproducing bladder tumors. Human and experimentalcarcinogenic data. Moderately toxic by intraperitonealroute. When heated to decomposition it emits very toxicfumes of Cl- and NOx.
職業ばく露
May be combustible and possibly
explosive. Not produced or used commercially in the
United States, Chlornaphazine has been used in other countries in the treatment of leukemia and related cancers.
Currently, this drug does not have wide therapeutic usage.
輸送方法
UN2810 Toxic liquids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name
Required. UN2588 Pesticides, solid, toxic, Hazard Class: 6.1;
Labels: 6.1-Poisonous materials, Technical Name Required.
純化方法
Crystallise it from pet ether. At 15o it is soluble in EtOH (3.2%), Et2O (50%), Me2CO (84%) and *C6H6 (80%). [Beilstein 12 III 2996, 12 IV 3126.] CARCINOGENIC.
不和合性
Keep away from oxidizers, nucleophiles,
and nitromethanes. Amines may react violently with nitric
acid; cellulose nitrate (of high surface area); 1-chloro-2,3-epoxypropane (exothermic reaction may occur). Incompatible with
acids, acid halides; alcohols, aldehydes, alkylene oxides; anhydrides, cresols, caprolactam solution; epichlorohydrin, epoxides, isocyanates, glycols, peroxides, phenols. Contact with
strong reducing agents may generate flammable hydrogen gas.
May attack copper and copper alloys.
廃棄物の処理
Disposal of unused product
must be undertaken by qualified personnel who are knowledgeable in all applicable regulations and follow all pertinent safety precautions including the use of appropriate
protective equipment. For proper handling and disposal,
always comply with federal, state, and local regulations.
N,N-ビス(2-クロロエチル)-2-ナフチルアミン 上流と下流の製品情報
原材料
準備製品