Triethyloxonium tetrafluoroborate
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Triethyloxonium tetrafluoroborate 속성
- 녹는점
- 96-97°C
- 밀도
- 1.328 g/mL at 25 °C
- 저장 조건
- 2-8°C
- 용해도
- 염화메틸렌: 20mg/mL, 투명, 무색
- 물리적 상태
- 가루
- 색상
- 하얀색
- 수용성
- 물과 반응
- 감도
- Moisture Sensitive
- Merck
- 14,5796
- BRN
- 3598090
- 노출 한도
- ACGIH: TWA 50 ppm
OSHA: TWA 25 ppm; STEL 125 ppm
NIOSH: IDLH 2300 ppm
- InChI
- InChI=1S/C6H15O.BF4/c1-4-7(5-2)6-3;2-1(3,4)5/h4-6H2,1-3H3;/q+1;-1
- InChIKey
- IYDQMLLDOVRSJJ-UHFFFAOYSA-N
- SMILES
- [B-](F)(F)(F)F.[O+](CC)(CC)CC
- CAS 데이터베이스
- 368-39-8(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | C | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 34-40-14-67-37 | ||
| 안전지침서 | 23-24/25-26-36/37/39-45-22 | ||
| 유엔번호(UN No.) | UN 3265 8/PG 2 | ||
| WGK 독일 | 2 | ||
| RTECS 번호 | RR4584700 | ||
| F 고인화성물질 | 3-10-16-21 | ||
| 위험 참고 사항 | Corrosive | ||
| TSCA | Yes | ||
| 위험 등급 | 4.1 | ||
| 포장분류 | II | ||
| HS 번호 | 29420000 | ||
| 독성 | dnd-smc 500 mmol/L CPBTAL 23,2485,75 |
Triethyloxonium tetrafluoroborate C화학적 특성, 용도, 생산
화학적 성질
white to light yellow crystal powder.용도
Triethyloxonium tetrafluoroborate is used as a powerful alkylating agent, especially for ethylation. It is used for the modification of carboxyl residues in proteins. It is involved in the preparation of μ-amino esters from lactams. It is also alkylating agent for nucleophilic functional groups in organic synthesis.주요 응용
Triethyloxonium tetrafluoroborate can be used:To prepare amino esters by reacting with lactams followed by hydrolysis.
In the preparation of substituted imidazolines from aziridines and nitriles via [3+2]-cycloaddition reaction.
For the N-alkylation of a series of N-arylsulfonyl-α-amino acid methyl esters having variable substituents at 4th position of the sulfonamide aromatic ring.
Synthesis of HDET2.
Safety Profile
Triethyloxonium tetrafluoroborate is a powerful ethylating agent, although the hazards are diminished because it is non-volatile. It releases strong acid upon contact with water. When heated to decomposition it emits toxic vapors of boronand Fí. Mutation data reported.Synthesis
Triethyloxonium tetrafluoroborate is prepared from boron trifluoride,diethyl ether and epichlorohydrin:4 Et2O·BF3+ 2 Et2O + 3 C2H3(O)CH2Cl → 3 Et3O+BF4+ B[(OCH(CH2Cl)CH2OEt]3
The trimethyloxonium salt is available from dimethyl ether via an analogous route.These salts do not have long shelf-lives at room temperature. They degrade by hydrolysis:
[(CH3CH2)3O]+BF4+ H2O → (CH3CH2)2O + CH3CH2OH +HBF4
Purification Methods
Crystallise it from diethyl ether. It is very hygroscopic, and must be handled in a dry box and stored at 0o. [Meerwein Org Synth Coll Vol V 1096 1973.] Pure material should give a clear and colourless solution in dichloromethane (1 in 50, w/v). [Beilstein 1 IV 1322.]Triethyloxonium tetrafluoroborate 준비 용품 및 원자재
원자재
준비 용품
에틸이소시아나이드
에틸4-하이드록시부타노에이트
(R)-2,5-디하이드로-3,6-디에톡시-2-이소프로필피라진
N,N-디에틸시클로헥실아민
1,1-디부톡시트리메틸아민
Ethylthiocyanate
질산 에틸
2-Bromo-1-ethylpyridinium tetrafluoroborate
6-에톡시-2,3,4,5-테트라히드로피리딘
2H-Pyrrole,2-(bromomethyl)-5-ethoxy-3,4-dihydro-,(S)-(9CI)
2-에톡시프롤
2-Ethoxy-1H-indole
Ethanimidic acid, 2-[[(phenylmethoxy)carbonyl]amino]-, ethyl ester
Triethyloxonium tetrafluoroborate 공급 업체
글로벌( 292)공급 업체
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