ChemicalBook >제품 카탈로그 >API>신경계 약물>항 경련제 및 항 경련제>(S)-MEPHENYTOIN

(S)-MEPHENYTOIN

(S)-MEPHENYTOIN 구조식 이미지

카스 번호:: 50-12-4

상품명:: (S)-MEPHENYTOIN

동의어(영문):: Epilan;Epiazin;Methoin;Metydan;Sacerno;Insulton;Fenantoin;Mesantoin;Mesontoin;NSC-34652

CBNumber:: CB0225135

분자식:: C12H14N2O2

포뮬러 무게:: 218.25

MOL 파일:: 50-12-4.mol

속성

안전

용도

공급 업체 105

(S)-MEPHENYTOIN 속성

녹는점: 135-138 °C

끓는 점: 358.94°C (rough estimate)

밀도: 1.154±0.06 g/cm3 (20 ºC 760 Torr)

굴절률: 1.6660 (estimate)

저장 조건: 2-8°C

용해도: DMSO(약간 용해됨), 에탄올(약간 용해됨), 메탄올(약간 용해됨)

물리적 상태: 고체

물리적 상태: 단단한 모양

산도 계수 (pKa): pKa 8.1 (Uncertain)

색상: 회백색

CAS 데이터베이스: 50-12-4(CAS DataBase Reference)

EPA: Mephenytoin (50-12-4)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	Xn
위험 카페고리 넘버	22-36/37/38
안전지침서	26-36
WGK 독일	2
HS 번호	2933210000
유해 물질 데이터	50-12-4(Hazardous Substances Data)
독성	LD50 i.p. in mice: 300 mg/kg (Dzhagatspanyan)

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	P- 코드
H302	삼키면 유해함	급성 독성 물질 - 경구	구분 4	경고	P264, P270, P301+P312, P330, P501
H315	피부에 자극을 일으킴	피부부식성 또는 자극성물질	구분 2	경고	P264, P280, P302+P352, P321,P332+P313, P362
H319	눈에 심한 자극을 일으킴	심한 눈 손상 또는 자극성 물질	구분 2A	경고	P264, P280, P305+P351+P338,P337+P313P
H335	호흡 자극성을 일으킬 수 있음	특정 표적장기 독성 - 1회 노출;호흡기계 자극	구분 3	경고

예방조치문구:

P261	분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P305+P351+P338	눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

(S)-MEPHENYTOIN C화학적 특성, 용도, 생산

개요

Mephenytoin is N-methylated at position 3 with an ethyl group replacing one of the phenyl substituents at position 5. It is indicated for focal and jacksonian seizures in patients refractory to less toxic AEDs. Mephenytoin produces more sedation than phenytoin and should be used only when safer drugs have failed, because it is associated with an increased incidence of serious toxicities, such as severe rash, agranulocytosis, and hepatitis. Its N-desmethyl metabolite, 5-phenyl- 5-ethylhydantoin, contributes to both efficacy and toxicity for mephenytoin. The drug is no longer commercially available inside but is still available outside the United States.

용도

Anticonvulsant.

생물학적 활성

CYP2C19 substrate. Anticonvulsant.

부작용

Side effects, including rash, fever, and fatal blood dyscrasia, prevent the use as an anticonvulsant drug of first choice.

Safety Profile

Poison by ingestion and intraperitoneal routes. Human systemic effects by ingestion: somnolence, hemorrhage, changes in teeth and supporting structures. Human mutation data reported. An experimental teratogen. An FDA proprietary drug used as an anticonvulsant. When heated to decomposition it emits toxic fumes of NOx.

(S)-MEPHENYTOIN 준비 용품 및 원자재

원자재

Cyanide, Quant Test Strips Dilute hydrochloric acid 프로피오페논 사이안화 칼륨 암모늄 카보네이트 중아황산나트륨 나트륨 MEPHOBARBITAL 1-(1-cyano-1-phenylpropyl)-3-methylurea 2,4-Imidazolidinedione, 5-ethyl-5-phenyl-, (+-)- 메틸아민 모노메틸유레아 요오드 메탄 N,N-디메틸포름아마이드 디메틸 아세탈

준비 용품

(S)-MEPHENYTOIN 공급 업체

글로벌( 105)공급 업체

공급자	전화	이메일	국가	제품 수	이점
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	28761	58
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
Shaanxi Didu New Materials Co. Ltd	+86-89586680 +86-13289823923	1026@dideu.com	China	9020	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3136	58
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	Mandy@hangyubiotech.com	China	11013	58
Mainchem Co., Ltd.	+86-0592-6210733	sale@mainchem.com	China	32360	55
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.	17702719238 17702719238	sales@sun-shinechem.com	China	904	64

(S)-MEPHENYTOIN 관련 검색:

Voriconazole 4-HYDROXY MEPHENYTOIN,4-HYDROXY MEPHENYTOIN (R)-1-METHYLMEPHENYTOIN (S)-MEPHENYTOIN (S)-Mephenytoin (R)-(-)-MEPHENYTOIN,(R)-MEPHENYTOIN,(R)-(-)-MEPHENYTOIN,(R)-MEPHENYTOIN 5-Phenylhydantoin 4-HYDROXY MEPHENYTOIN-D3,4-HYDROXY MEPHENYTOIN-D3 RAC MEPHENYTOIN-D3,RAC MEPHENYTOIN-D3 (+/-)-N-3-Benzylnirvanol DESMETHYL MEPHENYTOIN,DESMETHYL MEPHENYTOIN N-DESMETHYL MEPHENYTOIN-D5,N-DESMETHYL MEPHENYTOIN-D5 (S)-5-ETHYL-3-METHYL-5-PHENYLHYDANTOIN=(S)-MEPHENYTOIN,(S)-5-ETHYL-3-METHYL-5-PHENYLHYDANTOIN=(S)-MEPHENYTOIN (+/-)-4'-METHOXYMEPHENYTOIN S-[4-14C]MEPHENYTOIN,S-[4-14C]MEPHENYTOIN (4-ETHYL-2,5-DIOXO-4-PHENYLIMIDAZOLIDIN-1-YL)ACETIC ACID (2,5-DIOXO-3',4'-DIHYDRO-1H,2'H-SPIRO[IMIDAZOLIDINE-4,1'-NAPHTHALEN]-1-YL)ACETIC ACID (2,5-DIOXO-2',3'-DIHYDRO-1H-SPIRO[IMIDAZOLIDINE-4,1'-INDEN]-1-YL)ACETIC ACID