D-Pyroglutamic acid
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D-Pyroglutamic acid 속성
- 녹는점
- 155-162 °C
- 알파
- 27.5 º (c=10,1N NaOH)
- 끓는 점
- 239.15°C (rough estimate)
- 밀도
- 1.3816 (rough estimate)
- 굴절률
- 10 ° (C=5, H2O)
- 저장 조건
- Sealed in dry,Room Temperature
- 용해도
- 에 용해됨디메틸포름아미드, DMSO (약간 용해됨), 메탄올 (약간 용해됨), 물
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 3.48±0.20(Predicted)
- 색상
- 미색부터 밝은 베이지까지
- optical activity
- [α]22/D +10°, c = 1.5 in H2O
- 수용성
- 녹는
- Merck
- 14,8001
- BRN
- 82133
- InChIKey
- ODHCTXKNWHHXJC-GSVOUGTGSA-N
- CAS 데이터베이스
- 4042-36-8(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38 | ||
| 안전지침서 | 26-36-37/39 | ||
| WGK 독일 | 3 | ||
| HS 번호 | 29339900 |
D-Pyroglutamic acid C화학적 특성, 용도, 생산
개요
D-Pyroglutamic acid, also known as 5-oxo-D-proline, is a metabolite of D-glutamate. It is formed from D-glutamate by D-glutamate cyclase. The levels of D-pyroglutamic acid are increased in the urine of patients with nascent metabolic syndrome and the plasma of patients with end-stage renal disease.화학적 성질
white to light yellow crystal powder.정의
ChEBI: D-Pyroglutamic acid is the D-enantiomer of 5-oxoproline. It has a role as a metabolite. It is a D-proline derivative and a 5-oxoproline. It is a conjugate acid of a 5-oxo-D-prolinate. It is an enantiomer of a 5-oxo-L-proline.생물학적 활성
D-Pyroglutamic acid (PCA) is a cyclic derivative of glutamic acid, physiologically present in mammalian tissues. It has been shown that PCA releases GABA from the cerebral cortex and displays anti-anxiety effects in a simple approach-avoidance conflict situation in the rat. In clinical pharmacology experiments, PCA significantly shortens the plasma half-life of ethanol during acute intoxication.Purification Methods
Purify R-pyroglutamic acid by dissolving it in H2O, filtering, passing the filtrate through Dowex 50 (H+ form), washing with H2O, pooling washings, evaporating, removing H2O azeotropically with Me2CO and *C6H6, washing the residue with Et2O and recrystallising from EtOH/pet ether. [Pradeller et al. Collect Czech Chem Commun 42 79, 80 1977, Beilstein 22/6 V 7.]참고 문헌
1. Ariyoshi, M., Katane, M., Hamase, K., et al. D-Glutamate is metabolized in the heart mitochondria. Sci. Rep. 7, 43911 (2017). DOI:10.1038/srep439112. Shim, K., Gulhar, R., and Jialal, I. Exploratory metabolomics of nascent metabolic syndrome. J. Diabetes Complications 33(3), 212-216 (2019). DOI:10.1016/j.jdiacomp.2018.12.002
3. Palekar AG, et al. Accumulation of 50oxo-L-proline and 5-oxo-D-proline in the blood plasma in end stage renal disease. Biochem Med. 1975 Nov;14(3):339-45. DOI:10.1016/0006-2944(75)90052-6
4. D-Pyroglutamic Acid Production from L-Glutamic Acid by Successive Racemization, Resolution and Dehydration. DOI:10.6967/JCICE.200003.0177
D-Pyroglutamic acid 준비 용품 및 원자재
원자재
준비 용품
D-Pyroglutamic acid 공급 업체
글로벌( 478)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Chengdu Baishixing Science and Technology Industry Co.,Ltd | +86-15008457246 +86-15008457246 |
yuki@cd-bsx.com | China | 53 | 58 |
| Hebei Duling International Trade Co. LTD | +8617333973358 |
sales01@hbduling.cn | China | 15630 | 58 |
| Sichuan HongRi Pharma-Tech Co.,Ltd | +86-028-64841719 +8615680023009 |
daisy@enlaibio.com | China | 1369 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 15954 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21687 | 55 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Accela ChemBio Inc. | (+1)-858-699-3322 |
info@accelachem.com | United States | 19965 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8829 | 58 |
D-Pyroglutamic acid 관련 검색:
2-피롤리디논 L-글루타민산 아세트산 시트르산 스테아르산 엽산 L-(-)-프로린 2-피롤리돈-5-카르복실산 L-피로글루탐 산
D-Proline
Polyglutamic acid
GLDH
EPA
Ascoric Acid
Sodium L-pyroglutamate
(R)-N-BOC-5-METHOXYCARBONYL-2-PYRROLIDINONE
Ethyl D-(-)-pyroglutamate
Z-L-PYROGLUTAMIC ACID,N-ALPHA-CARBOBENZOXY-L-PYROGLUTAMIC ACID,N-ALPHA-CBZ-L-PYROGLUTAMIC ACID,N-BENZYLOXYCARBONYL-L-PYROGLUTAMIC ACID,N-CBZ-L-PYROGLUTAMIC ACID