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Latanoprost

Latanoprost 구조식 이미지

카스 번호:: 130209-82-4

상품명:: Latanoprost

동의어(영문):: 17-PHENYL-13,14-DIHYDRO TRINOR PROSTAGLANDIN F2ALPHA ISOPROPYL ESTER;Isopropyl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate;xa41;Xalata;phxa41;Latanopros;LATANOPROST;LATANAPROST;Latanoprost>Latanoprost CAS

CBNumber:: CB1208384

분자식:: C26H40O5

포뮬러 무게:: 432.59

MOL 파일:: 130209-82-4.mol

MSDS 파일:: SDS

속성

안전

용도

공급 업체 553

Latanoprost 속성

알파: D20 +31.57° (c = 0.91 in acetonitrile)

끓는 점: 583.8±50.0 °C(Predicted)

밀도: 1.093±0.06 g/cm3(Predicted)

저장 조건: -20°C

용해도: DMSO: 자유롭게 용해됨

물리적 상태: 기름

산도 계수 (pKa): 14.84±0.70(Predicted)

색상: 옅은 노랑

Merck: 14,5376

BCS Class: 2

InChIKey: GGXICVAJURFBLW-RDSJPUOVSA-N

CAS 데이터베이스: 130209-82-4(CAS DataBase Reference)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

WGK 독일	3
RTECS 번호	MJ9669550
HS 번호	2937500000

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H413	장기적 영향에 의해 수생생물에 유해의 우려가 있음	수생 환경유해성 물질 - 만성	구분 4

예방조치문구:

P273

환경으로 배출하지 마시오.

NFPA 704

	0
3		0

Latanoprost C화학적 특성, 용도, 생산

개요

Xalatan was launched in Sweden, Switzerland and the US for the treatment of glaucoma. It can be synthesized, from the Corey lactone, using standard prostaglandin chemistry. Latanoprost is a PGF_2α, analog that is more lipophilic thus is better able to penetrate the cornea. The (15R)-diastereomer has only 10% of the activity compared to the (15S)-diastereomer. It is a selective FP receptor agonist with little or no effect on the other prostanoid receptors. The antiglaucoma effects are the result of reduced intraocular pressure arising by increasing uveoscleral outflow with little or no effect on trabeculo-canalicular aqueous outflow and no effect on retinal vasculation or permeability of the blood-aqueous barrier. The topical application is sufficient for a single daily dosage and is well tolerated with no detectible conjunctival hyperaemia.

화학적 성질

Light Yellow Thick Oil

용도

Latanoprost is the isopropyl ester of 17-phenyl-13,14-dihydro prostaglandin F2α (17-phenyl-13,14-dihydro PGF2α). It is a prodrug form of the free acid, which is a potent agonist of the FP receptor in the eye. Latanoprost reduces intraocular pressure in glaucoma patients with few side effects. The EC50 value of latanoprost (tested as the free acid) for FP receptors is 3.6 nM.

정의

ChEBI: A prostaglandin Falpha that is the isopropyl ester prodrug of latanoprost free acid. Used in the treatment of open-angle glaucoma and ocular hypertension.

일반 설명

Latanoprost (Xalatan) is available as a 0.005% sterileophthalmic solution in a 2.5-mL dispenser bottle.Latanoprost is also marketed as a combination ophthalmicproduct with the β-adrenergic blocking agent, timolol,which apparently enhances IOP-lowering by decreasing theproduction of aqueous humor. Cautions and side effects aresimilar to those for other ophthalmic prostanoids.

Safety Profile

A poison by ingestion and intravenous route. Human systemic effects. When heated to decomposition it emits acrid smoke and irritating vapors.

Latanoprost 준비 용품 및 원자재

원자재

5-(아세트아미도)-N,N'-비스(2,3-디히드록시프로필)-2,4,6-트리요도-1,3-벤젠디카르복스아미드 디사이클로헥실카르보디이미디 염화 리튬 트리스(하이드록시메틸)아미노메탄 요오드화이소프로필 트리에틸아민 세슘 탄소산 수산화칼륨 백금분 (+)-Diisopinocampheyl chloroborane

준비 용품

Latanoprost 공급 업체

글로벌( 553)공급 업체

공급자	전화	이메일	국가	제품 수	이점
AFINE CHEMICALS LIMITED	+86-0571-85134551	info@afinechem.com	China	15396	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12470	58
Nantong Guangyuan Chemicl Co,Ltd	+undefined17712220823	admin@guyunchem.com	China	616	58
Wuhan Quanjinci New Material Co.,Ltd.	+8615271838296	kyra@quanjinci.com	China	1534	58
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	info@fdachem.com	China	18214	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21687	55
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	fandachem@gmail.com	China	9341	55
Shanghai finete Pharmaceutical Co., Ltd.	+86-18221039705		CHINA	139	55
Nanjing ChemLin Chemical Industry Co., Ltd.	025-83697070	product@chemlin.com.cn	CHINA	3012	60

Latanoprost 관련 검색:

페닐 살리실산 클로로사이클로펜테인 시클로펜탄 사이클로펜틸브로마이드 프로판 디페닐에테르 페닐초산 LATANOPROST LACTONE DIOL PHENYL VALERATE CHLOROPHOSPHONAZO III Prostaglandin E1 2'-Hydroxy-3-phenylpropiophenone LATANOPROST (FREE ACID),LATANOPROST ACID Solvent Red 43 Prostaglandin E2 Travoprost Dorzolamide Hydrochloride Latanoprost Epoxide (Mixture of isoMers)