올레일알코올
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올레일알코올 속성
- 녹는점
- 0-5.0 °C (lit.)
- 끓는 점
- 207 °C/13 mmHg (lit.)
- 밀도
- 0.849 g/mL at 25 °C (lit.)
- 증기압
- 10.64 hPa (195 °C)
- 굴절률
- n
20/D 1.46(lit.)
- 인화점
- >230 °F
- 저장 조건
- -20°C
- 용해도
- Soluble in ethanol (95%), and ether; practically insoluble in water.
- 물리적 상태
- 점성 액체
- 산도 계수 (pKa)
- 15.20±0.10(Predicted)
- 색상
- 거의 무색~황색으로 투명함
- 냄새
- 지방이 많은 동물
- ?? ??
- 지방이 많은
- 수용성
- 알코올 및 에테르와 혼합 가능. 사염화탄소와 약간 섞임. 물과 섞이지 않습니다.
- Merck
- 14,6831
- JECFA Number
- 1637
- BRN
- 1723962
- 안정성
- 안정적인. 타기 쉬운. 강산, 강산화제와 호환되지 않습니다.
- LogP
- 7.07 at 25℃
- CAS 데이터베이스
- 143-28-2(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 38 | ||
| 안전지침서 | 26-36 | ||
| WGK 독일 | - | ||
| RTECS 번호 | RG4120000 | ||
| TSCA | Yes | ||
| HS 번호 | 29052990 | ||
| 유해 물질 데이터 | 143-28-2(Hazardous Substances Data) | ||
| 독성 | LD50 orally in Rabbit: > 5000 mg/kg | ||
| 기존화학 물질 | KE-26527 |
올레일알코올 C화학적 특성, 용도, 생산
화학적 성질
Oleyl alcohol occurs as a pale yellow oily liquid that gives off acrid fumes when heated.용도
oleyl alcohol is an emollient, solvent, viscosity-increasing agent, and carrier employed in a wide variety of cosmetic formulations including makeup, skin care, and hand and body preparations. oleyl alcohol is an unsaturated fatty alcohol found in fish oils and can also be produced synthetically. According to some sources, it is comedogenic and has a mild irritancy potential.생산 방법
Oleyl alcohol occurs naturally in fish oils. Synthetically, it can be prepared from butyl oleate by a Bouveault–Blanc reduction with sodium and butyl alcohol. An alternative method of manufacture is by the hydrogenation of triolein in the presence of zinc chromite.정의
ChEBI: A long chain fatty alcohol that is octadecanol containing a double bond located at position 9 (the Z-geoisomer).일반 설명
Oleyl alcohol has been reported as an effective solvent for oil/water-type tacrolimus (FK506) cream formulation, useful for atopic dermatitis treatment. It was reported as diluting agent for Alamine 336. Palm oil esters derived from oleyl alcohol, have potential applications in the cosmetic and pharmaceutical industries due to the excellent wetting behavior of the esters without the oily feel.Pharmaceutical Applications
Oleyl alcohol is mainly used in topical pharmaceutical formulations and has been used in transdermal delivery formulations.It has been utilized in the development of biodegradable injectable thermoplastic oligomers,and in aerosol formulations of insulin and albuterol.Therapeutically, it has been suggested that oleyl alcohol may exhibit antitumor properties via transmembrane permeation.
Safety Profile
A human skin and eye irritant. Aningredient in cosmetics. When heated to decomposition itemits acrid smoke and irritating fumes.Safety
Oleyl alcohol is mainly used in topical pharmaceutical formulations and is generally regarded as a nontoxic and nonirritant material at the levels employed as an excipient. However, contact dermatitis due to oleyl alcohol has been reported.The results of acute oral toxicity and percutaneous studies in animals with products containing 8% oleyl alcohol indicate a very low toxicity. Formulations containing 8% or 20% oleyl alcohol administered by gastric intubation, at doses up to 10 g/kg bodyweight, caused no deaths and no toxic effects in rats.
저장
The bulk material should be stored in a well-closed container in a cool, dry, place.Purification Methods
Purify it by fractional crystallisation at -40o from acetone, then distil it under vacuum. [Beilstein 2 IV 2204.]Regulatory Status
Included in the FDA Inactive Ingredients Database (topical emulsions and ointments). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.올레일알코올 준비 용품 및 원자재
원자재
준비 용품
올레일알코올 공급 업체
글로벌( 291)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12469 | 58 |
| Hebei Guanlang Biotechnology Co,.LTD | +86-19930503253; +8619930503252 |
daisy@crovellbio.com | China | 5957 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2503 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 18218 | 58 |
| Hebei Saisier Technology Co., LTD | +86-18400010335 +86-18034520335 |
admin@hbsaisier.cn | China | 940 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 |
admin@zlchemi.com | China | 2685 | 58 |
| Hebei Longbang Technology Co., LTD | +86-18032476855 +86-18032476855 |
admin@hblongbang.com | China | 914 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21688 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 |
jack.li@time-chemicals.com | China | 1807 | 55 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |