Butenafine

Butenafine 구조식 이미지
카스 번호:
101828-21-1
상품명:
Butenafine
동의어(영문):
But·Nafine;BUTENAFINE;Butenafine USP/EP/BP;4-tert-Butylbenzylmethyl 1-naphtylmethylamine;(4-tert-butylbenzyl)-methyl-(1-naphthylmethyl)amine;N-methyl-N-(4-methylbenzyl)-N-(1-naphthylmethyl)amine;N-(4-tert-Butylbenzyl)-N-methyl-1-naphthalenemethanamine;n-(p-tert-butylbenzyl)-n-methyl-1-naphthalenemethylamine;1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine;n-methyl-n-(naphthalen-1-ylmethyl)-1-(4-tert-butylphenyl)methanamine
CBNumber:
CB1742475
분자식:
C23H27N
포뮬러 무게:
317.47
MOL 파일:
101828-21-1.mol

Butenafine 속성

녹는점
200-202 °C
끓는 점
426.1±14.0 °C(Predicted)
밀도
1.032±0.06 g/cm3(Predicted)
저장 조건
Store at -20°C
용해도
DMSO: 63 mg/mL (198.44 mM);Ethanol: 63 mg/mL (198.44 mM)
산도 계수 (pKa)
7.87±0.50(Predicted)
수용성
Water: Insoluble
LogP
6.770 (est)
CAS 데이터베이스
101828-21-1(CAS DataBase Reference)

안전

Butenafine C화학적 특성, 용도, 생산

용도

Butenafine (Mentax) is a synthetic benzylamine antifungal agent, related structurally and pharmacologically to terbinafine. It is thought to act by inhibiting the enzyme squalene 2,3-epoxidase, resulting in decreased ergosterol and corresponding increase in squalene, with subsequent cell membrane permeability alteration and cell death. It is active against dermatophytes, yeast, and Sporothrix.
Butenafine (Mentax)

정의

ChEBI: Trimethylamine in which hydrogen atoms attached to different methyl groups are substituted by 1-naphthyl and 4-tert-butylphenyl groups. It is an inhibitor of squalene epoxidase, an enzyme responsible for the creation of sterols needed in funga cell membranes, and is used as its hydrochloride salt for treatment of dermatological fungal infections.

상표명

Lotrimin (Schering); Mentax (Mylan Bertek).

Butenafine 준비 용품 및 원자재

원자재

준비 용품


Butenafine 공급 업체

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