시클로프로필아민
|
|
시클로프로필아민 속성
- 녹는점
- -50 °C
- 끓는 점
- 49-50 °C (lit.)
- 밀도
- 0.824 g/mL at 25 °C (lit.)
- 증기압
- 4.67 psi ( 20 °C)
- 굴절률
- n
20/D 1.420(lit.)
- 인화점
- −14 °F
- 저장 조건
- Store below +30°C.
- 용해도
- Chloroform, Ethyl Acetate (Sparingly), Methanol (Slightly)
- 물리적 상태
- 휘발성 액체
- 산도 계수 (pKa)
- pK1:9.10(+1) (25°C)
- 색상
- 무색의
- Specific Gravity
- 0.824
- 수용성
- 물, 에탄올, 에테르, 클로로포름과 혼합 가능.
- 감도
- Lachrymatory
- BRN
- 741858
- 안정성
- 휘발성 물질
- InChIKey
- HTJDQJBWANPRPF-UHFFFAOYSA-N
- LogP
- 0.070
- CAS 데이터베이스
- 765-30-0(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | F,C,Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 11-22-34-36/37 | ||
| 안전지침서 | 16-26-36/37/39-45-33-7/9 | ||
| 유엔번호(UN No.) | UN 2733 3/PG 2 | ||
| WGK 독일 | 2 | ||
| RTECS 번호 | GZ0685500 | ||
| 자연 발화 온도 | 527 °F | ||
| 위험 참고 사항 | Extremely Flammable/Harmful/Corrosive/Lachrymatory | ||
| TSCA | T | ||
| 위험 등급 | 3 | ||
| 포장분류 | II | ||
| HS 번호 | 29213099 | ||
| 독성 | LD50 orally in Rabbit: 445 mg/kg | ||
| 기존화학 물질 | KE-09316 |
시클로프로필아민 C화학적 특성, 용도, 생산
용도
시클로 프로필 아민 농약 및 주로 시프 로플록사신 생산에 사용되는 제약 중간체는 살충제 및 식물 보호자의 합성에도 사용됩니다. 중간체로서 살충제와 식물 보호자의 합성에도 사용됩니다.화학적 성질
Cyclopropylamine is a colorless and transparent flammable liquid with volatility and ammonia odor. It is miscible with water, methanol, ethanol, benzene, toluene and other solvents.용도
Cyclopropylamine is used in the preparation of N-[4-(4-fluoro)phenyl-2-aminothiazol-5-yl]pyrimidin-2-yl-alkylamine derivatives. It is also used to prepare Pt(CPA)2(bismethylthiomethylenepropanedioate) and Pt(CPA)2(bisethylthiomethylenepropanedioate) complexes.정의
ChEBI: Cyclopropylamine is a primary aliphatic amine that consists of cyclopropane bearing a single amino substituent. It has a role as a mouse metabolite.주요 응용
Cyclopropylamine is mainly used in organic synthesis, pharmaceutical synthesis intermediates, and can be used in the synthesis of new antibacterial drugs ciprofloxacin products, such as the synthesis of ciprofloxacin, enrofloxacin, spafloxacin and other drugs. In addition, cyclopropylamine is also an important intermediate for the synthesis of pesticides, plant protection agents and herbicides, such as 2-chloro-4-6-cyclopropyl-s-triazine, cyprochlor, cyproterazine, cyprocyanine and other cyclopropanes class of pesticides.제조 방법
Cyclopropylamine is synthesized from 1,3-propanediol by bromination, cyanation, cyclization, amidation, and Hoffmann rearrangement. It is also synthesized with γ-butyrolactone and isopropanol by five steps of ring-opening esterification, cyclization, hydrolysis, acylation and Hofmann degradation.Purification Methods
It has been isolated as the benzamide m 100.6-101.0o (from aqueous EtOH). It forms a picrate m 149o (from EtOH/pet ether) from which the free base can be recovered using a basic ion-exchange resin and can then be distilled through a Todd column (p 11) using an automatic still head which only collects products boiling below 51o/atm. Polymeric materials if present will boil above this temperature. The hydrochloride has m 85-86o [Roberts & Chambers J Am Chem Soc 73 5030 1951, Jones J Org Chem 9 484 1944, Emmons J Am Chem Soc 79 6522 1957]. [Beilstein 12 IV 3.]시클로프로필아민 준비 용품 및 원자재
원자재
준비 용품
1-CYCLOPROPYLPIPERAZINE
4-CHLORO-3-((CYCLOPROPYLAMINO)METHYL)BENZALDEHYDE
Ciprofloxacin hydrochloride
시로마진
3-BROMO-2-((CYCLOPROPYLAMINO)METHYL)BENZALDEHYDE
7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-4-oxoquinoline-3-carboxylic acid
에틸3-(사이클로프로필아미노)아크릴레이트
1-(3-CHLORO-4-((CYCLOPROPYLAMINO)METHYL)PHENYL)ETHANONE
2-N-Cyclopropylamino-4,6-DichloroTriazine
1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid
Dicyclanil
Enrofloxacin hydrochloride
시프로플록사신
Sparfloxacin
3-CHLORO-4-((CYCLOPROPYLAMINO)METHYL)BENZALDEHYDE
7-Chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-8-methyl-4-oxoquinoline-3-carboxylic acid
2-니트로소-1-나프톨
N-사이클로프로필4-클로로피콜리나미드
시클로프로필아민 공급 업체
글로벌( 556)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Changzhou Rokechem Technology Co., Ltd. | 18758118018 |
sales001@rokechem.com | China | 255 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21687 | 55 |
| Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 |
jack.li@time-chemicals.com | China | 1807 | 55 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9341 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32715 | 60 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 |
info@tnjchem.com | China | 2989 | 55 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| NINGBO INNO PHARMCHEM CO., LTD. | 13867897135 |
sales@nbinno.com | CHINA | 925 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
시클로프로필아민 관련 검색:
이소프로필아민 다이아이소프로필아민 시로마진 시프로플록사신 프로필아민 시클로프로필아민
Tranylcypromine
Tranylcypromine Hemisulfate
1-(Cbz-amino)cyclopropanecarboxylic acid
1-Aminocyclopropane-1-carboxylic acid hydrochloride
Methyl 1-aminocyclopropanecarboxylate hydrochloride
TRANS-2-PHENYLCYCLOPROPYL ISOCYANATE
D/L-AMPHETAMINE HYDROCHLORIDE
(-)-2-[METHYLAMINO]-1-PHENYLPROPANE
Rolicyprine
Lorbamate
CYCLOPROPYL ISOTHIOCYANATE
1-Aminocyclopropanecarboxylic acid