phenoxybenzamine
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phenoxybenzamine 속성
- 녹는점
- 38-40°
- 끓는 점
- 381.5±27.0 °C(Predicted)
- 밀도
- 1.0513 (rough estimate)
- 굴절률
- 1.5600 (estimate)
- 산도 계수 (pKa)
- 6.58±0.50(Predicted)
- 색상
- 석유 에테르에서 결정화
- CAS 데이터베이스
- 59-96-1
안전
| 유해 물질 데이터 | 59-96-1(Hazardous Substances Data) | ||
|---|---|---|---|
| 독성 | LD50 oral in rat: 2500mg/kg |
phenoxybenzamine C화학적 특성, 용도, 생산
용도
Antihypertensive.World Health Organization (WHO)
Phenoxybenzamine, a long-acting alpha-adrenoreceptor antagonist, was introduced in 1953 and has been used in a variety of peripheral vascular disorders. In 1982 it was shown to have mutagenic activity and in 1985 it was found to be carcinogenic in the rat. Its approved use was subsequently restricted by several regulatory authorities and phenoxybenzamine is currently used to manage hypertensive episodes associated with phaeochromocytoma, as an adjunct to the short-term management of urinary retention due to neurogenic bladder, in the short-term treatment of benign prostatic hypertrophy in patients awaiting surgery, and in inoperable benign prostatic hypertrophy.Safety Profile
Confirmed carcinogen with experimental carcinogenic and neoplastigenic data. Poison by intravenous and intracerebral routes. Moderately toxic by ingestion. Human reproductive effects by ingestion: spermatogenesis. Experimental reproductive effects. When heated to decomposition it emits very toxic fumes of Cland NOx.Purification Methods
The free base is crystallised from pet ether, and the HCl is crystallised from EtOH/diethyl ether. [Beilstein 12 IV 2204.]phenoxybenzamine 준비 용품 및 원자재
원자재
준비 용품
phenoxybenzamine 공급 업체
글로벌( 26)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 |
1057@dideu.com | China | 2870 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 |
1026@dideu.com | China | 9126 | 58 |
| Finetech Industry Limited | +86-27-87465837 +8618971612321 |
info@finetechnology-ind.com | China | 9635 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 |
info@dycnchem.com | CHINA | 52867 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 |
info@gihichemicals.com | China | 50000 | 58 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 |
waley188@sohu.com | China | 12338 | 58 |
| TargetMol Chemicals Inc. | 021-021-33632979 15002134094 |
marketing@targetmol.com | China | 7854 | 58 |
| Finetech Industry Limited | 027-87465837 19945049750 |
sales@finetechnology-ind.com | China | 9635 | 58 |
| Chengdu Saint - Kay Biotechnology Co., Ltd. | 028-85157043 15882256948 |
676046971@qq.com | China | 4393 | 58 |