Angiotensin I, human

Angiotensin I, human C화학적 특성, 용도, 생산

Biological Functions

In 1988, a series of reports described the ability of imidazole acetic acid derivatives to act as antagonists at the angiotensin receptor.During the course of characterization of these compounds, it became apparent that certain tissues contained different subtypes of angiotensin receptors. Angiotensin receptors have been classified into two subtypes,AT1 and AT2. Each receptor subtype has been cloned and sequenced, with only 32% homology in the protein sequences for the two receptors. The AT1 receptor uses G proteins as signal transducers and is coupled through traditional second-messenger systems that involve phospholipase C and calcium mobilization, inhibition of adenylyl cyclase, stimulation of mitogen-activated protein kinases and the JAK/STAT pathway, and activation of Jun-kinase. In contrast, the signaling cascades of the AT2 receptor involve the activation of phosphorylases, which inhibit phosphorylation steps of certain types of cell growth.
The distribution of the AT1 and AT2 receptor subtypes is species and tissue specific. The major biological functions of angiotensin II (cardiovascular regulation) are mediated through the ATI receptor. In contrast, despite the increased presence of AT2 receptors in fetal tissues, a lack of AT2 receptors appears to be compatible with life. Current evidence suggests that in general, stimulation of the AT2 receptor appears to oppose those physiological actions of angiotensin II that are mediated through the AT1 receptor.
Angiotensin IV, the smallest bioactive peptide product of the renin–angiotensin system, interacts with a unique receptor termed the angiotensin IV receptor; this receptor exhibits minimal affinity for angiotensin II or angiotensin III.

Angiotensin I, human 준비 용품 및 원자재

원자재

준비 용품

Angiotensin I, human 공급 업체

공급자	전화	이메일	국가	제품 수	이점
Wuxi Zhongkun Biochemical Technology Co., Ltd.	0510-85629785 18013409632	sales@reading-chemicals.com	China	15185	58
Hangzhou Peptide Biochem Co.,Ltd	0571-89197072; 18668118770	linda@peptide-china.com	China	248	56
Hangzhou Xinhai Pharmaceutical Technology Co., Ltd.	0571-86758863 13867485072	lulu@thinheal.com	China	300	58
Wuxi Helen Biotechnology Co., Ltd.,	0510-85629785 18013409632	sales@reading-chemicals.com	China	14092	58
Nanjing Yuanpeptide Biotech Co.，Ltd.	18168071971	support@yuan-peptide.com	China	2977	58
Chengdu Jinglin Biotechnology Co., Ltd.	17711399154	3211919385@qq.com	China	1815	58
Shaoxing Junyu Biotechnology Co., LTD	0571-88211921 15572296305	sales4@gotopbio.com	China	5144	58
Zhejiang Jiekun Biotechnology Co., Ltd	0571-88211951 13735575465	sales1@gotopbio.com	China	4904	58