장기(또는, 영향을 받은 알려진 모든 장기를 명시)에 손상을 일으킴(노출되어도 특정 표적장기 독성을 일으키지 않는다는 결정적인 노출경로가 있다면 노출경로를 기재)
특정 표적장기 독성 - 1회 노출
구분 1
위험
P260, P264, P270, P307+P311, P321,P405, P501
예방조치문구:
P210
열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.
P260
분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.
P280
보호장갑/보호의/보안경/안면보호구를 착용하시오.
P301+P310
삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.
P311
의료기관(의사)의 진찰을 받으시오.
NFPA 704
0
2
0
클로르디아제프 C화학적 특성, 용도, 생산
화학적 성질
Pale Yellow Solid
용도
Controlled substance (depressant). Anxiolytic. Prototype of the benzodiazepine anxiolytics
정의
ChEBI: A benzodiazepine that is 3H-1,4-benzodiazepine 4-oxide substituted by a chloro group at position 7, a phenyl group at position 5 and a methylamino group at position 2.
위험도
Anticonvulsant, sedative, and amnesic
properties.
신진 대사
Chlordiazepoxide is well absorbed after oral administration, and peak blood concentration usually is reached in
approximately 4 hours. Intramuscular absorption of chlordiazepoxide, however, is slower and erratic. The half-life of
chlordiazepoxide is variable but usually quite long (6–30 hours). The initial N-demethylation product,
N-desmethylchloridiazepoxide, undergoes deamination to form the demoxepam, which is extensively
metabolized, and less than 1% of a dose of chlordiazepoxide is excreted as demoxepam. Demoxepam can undergo
four different metabolic fates. Removal of the N-oxide moiety yields the active metabolite, N-desmethyldiazepam
(desoxydemoxepam). This product is a metabolite of both chlordiazepoxide and diazepam and can be hydroxylated
to yield oxazepam, another active metabolite that is rapidly glucuronidated and excreted in the urine. Another possibility for metabolism of demoxepam is hydrolysis to the “opened lactam,”
which is inactive. The two other metabolites of demoxepam are the products of ring A hydroxylation
(9-hydroxydemoxepam) or ring C hydroxylation (4′-hydroxydemoxepam), both of which are inactive.
