Chloramphenicol hemisuccinate
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Chloramphenicol hemisuccinate 속성
- 녹는점
- 127 °C
- 끓는 점
- 716.3±60.0 °C(Predicted)
- 밀도
- 1.6769 (rough estimate)
- 굴절률
- 1.7350 (estimate)
- 저장 조건
- Store at -20°C
- 용해도
- DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
- 물리적 상태
- 고체
- 산도 계수 (pKa)
- 4.36±0.17(Predicted)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
Chloramphenicol hemisuccinate C화학적 특성, 용도, 생산
개요
Chloramphenicol succinate is a water-soluble prodrug form of the antibiotic chloramphenicol. It is a substrate for succinate dehydrogenase (SDH) and is oxidized by human liver and rat liver and kidney mitochondria to release chloramphenicol in vitro. Chloramphenicol succinate reduces human leukocyte migration in vitro. In vivo, chloramphenicol succinate reduces E. coli growth in rabbit and rat models of pyelonephritis when administered at doses of 150 and 200 mg/kg, respectively. Chloramphenicol succinate (20 mg/kg) reduces infarct size in a porcine model of myocardial ischemia-reperfusion injury. Formulations containing chloramphenicol succinate have been used in the treatment of severe bacterial infections.용도
Chloramphenicol succinate is prepared by acylation of chloramphenicol with succinic anhydride to provide a water soluble pro-drug. Chloramphenicol succinate represents an alternative pro-drug strategy for chloramphenicol that has found a niche in surface antibiotic treatment in surgery. Chloramphenicol succinate is significantly less active than chloramphenicol but acts as a prodrug, forming chloramphenicol in the presence of succinate dehydrogenase.Chloramphenicol hemisuccinate 준비 용품 및 원자재
원자재
준비 용품
Chloramphenicol hemisuccinate 공급 업체
글로벌( 37)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49391 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 |
sales@tnjchem.com | China | 34572 | 58 |
AFINE CHEMICALS LIMITED | 0571-85134551 18958018566; |
info@afinechem.com | China | 15377 | 58 |
BOC Sciences | +16314854226 |
inquiry@bocsci.com | United States | 19743 | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 |
info@dycnchem.com | CHINA | 52867 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503259 +86-19930503259 |
cherry@crovellbio.com | China | 18451 | 58 |
GIHI CHEMICALS CO.,LIMITED | +8618058761490 |
info@gihichemicals.com | China | 50000 | 58 |
Aladdin Scientific | +1-833-552-7181 |
sales@aladdinsci.com | United States | 57511 | 58 |
HangZhou YuHao Chemical Technology Co., Ltd. | 0571-82693216 |
info@yuhaochemical.com | China | 2031 | 58 |
Chloramphenicol hemisuccinate 관련 검색:
염화암페니콜 디페닐디클로로실란 베타인 숙신산이나트륨 디클로로메틸페닐실란 글리신 숙신산
Metroprolol succinate
D-α-Tocopherol succinate
CHLOROPHOSPHONAZO III
ALTRENOGEST
Chloramphenicol sodium succinate
Diphenyldiethoxysilane
Erythromycin ethylsuccinate
4-Methoxyphenylacetone
iron succinate
Chloramphenicol hemisuccinate
Chloromycin succinate