하이드록시디온나트륨

하이드록시디온나트륨
하이드록시디온나트륨 구조식 이미지
카스 번호:
53-10-1
한글명:
하이드록시디온나트륨
동의어(한글):
하이드록시디온나트륨
상품명:
HYDROXYDIONESODIUM
동의어(영문):
Viadril;Presuren;HYDROXYDION;HYDROXYDIONESODIUM;Hydroxidioni natrii succinas;Hidroxidiona succinato sodico;HYDROXYDIONESODIUMSUCCINATE USP/EP/BP;Hidroxidiona succinato sodico [inn-spanish];21-Hydroxypregnane-3,20-dione sodium hemisuccinate;Succinic acid 1-sodium 4-(3,20-dioxo-5β-pregnane-21-yl)
CBNumber:
CB31406549
분자식:
C25H35NaO6
포뮬러 무게:
454.54
MOL 파일:
53-10-1.mol

하이드록시디온나트륨 속성

안전

하이드록시디온나트륨 C화학적 특성, 용도, 생산

Originator

Viadril,Pfizer,US,1957

Manufacturing Process

A solution of 20 g of desoxycorticosterone in 190 ml of absolute ethanol was stirred in an atmosphere of hydrogen in the presence of 1.68 g of 25% palladium on calcium carbonate catalyst. After 20 hours, approximately 1 molar equivalent of hydrogen had been absorbed and hydrogen uptake had ceased. The catalyst was removed by filtration and the filtrate evaporated in vacuo to yield 20 g of nearly pure product, MP 135°C to 140°C. The crude product was demonstrated to be free of starting material by paper chromatography. A highly purified product was obtained by recrystallization from acetone-water with cooling in an ice bath, yield 14.5 g, MP 152°C to 154°C. The product was characterized by analysis and by absence of ultraviolet absorption.
A solution of 14 g of 21-hydroxypregnane-3,20-dione and of 14 g of recrystallized succinic anhydride in 140 ml of dry pyridine was allowed to stand at room temperature for 18 hours, then cooled in an ice bath and poured in a fine stream into 1.5 liters of ice water. Excess pyridine was neutralized with 3N hydrochloric acid and the solution further diluted with 2 liters of ice water. The precipitated product was filtered, washed with water and dried in vacuo at 50°C affording 18 g of solid MP 192°C to 195°C. Recrystallization of a small sample afforded analytically pure material, MP 200°C.

Therapeutic Function

Anesthetic

하이드록시디온나트륨 준비 용품 및 원자재

원자재

준비 용품


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