Oleamide has been used as a supplement in glucose and galactose media to prevent the rescue of galactose-induced Leigh syndrome (LS).
정의
ChEBI: A fatty amide derived from oleic acid.
일반 설명
Oleamide?is a lipid or a brain fatty acid, that is found in the CSF (cerebrospinal fluid). It is originally obtained from the cerebrospinal fluid of cats, that are sleep-deprived.
생물학적 활성
Endogenous sleep-inducing lipid. Acts as an agonist at the CB 1 cannabinoid receptor (EC 50 = 1.64 μ M). Also appears to potentiate the actions of 5-HT on 5-HT 2A and 2C receptors, and act via an allosteric regulatory site on 5-HT 7 receptors.
Synthesis
Oleamide can be synthesized by ammonolysis of fatty acid or esters with ammonia gas at high pressure.