N-니트로소-N-메틸우레아 C화학적 특성, 용도, 생산
개요
Methylnitrosourea (MNU) is a methylated nitrosourea compound
with alkylating,mutagenic, teratogenic, carcinogenic, and
cytotoxic properties. The toxic effects of MNU are caused by the
transfer of its methyl group to nucleobases in nucleic acids.
화학적 성질
Off-White to Pale Yellow Solid
용도
Precursor of Diazomethane. It has a cytotoxicity effect.
This product contains an undetermined amount of water
일반 설명
Pale yellow crystals or light yellow moist powder.
공기와 물의 반응
Sensitive to humidity and light when pure. Insoluble in water. Slowly decomposes in water. Alkaline hydrolysis produces a highly toxic, irritating and explosive gas.
반응 프로필
1-Methyl-1-nitrosourea is incompatible with strong acids and bases. Also incompatible with water and nucleophilic reagents. Alkaline hydrolysis produces a highly toxic, irritating and explosive gas. Can detonate with (potassium hydroxide + methylene chloride) .
화재위험
Flash point data for 1-Methyl-1-nitrosourea are not available; however, 1-Methyl-1-nitrosourea is probably combustible.
Safety Profile
Confirmed carcinogen
with experimental carcinogenic,
neoplastigenic, tumorigenic, and teratogenic
data. Poison by ingestion and intravenous
routes. Experimental reproductive effects.
Human mutation data reported. Explodes at
room temperature. Can detonate with
(KOH + CHzCh). When heated to
decomposition it emits toxic fumes of NOx.
Carcinogenicity
N-Nitroso-N-methylurea is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
환경귀착
There is no evidence that MNU has ever been produced or used
commercially; therefore, no data from human case reports or
epidemiological studies are available. MNU is available in small
quantities for research purposes and may be released into the
environment with laboratory waste. In air, MNU is expected
to exist solely as a vapor with an estimated vapor pressure of
2.9×10
-2 mmHg at 25℃. Vapor-phase MNU is expected to
degrade in the atmosphere by reaction with photochemically
produced hydroxyl radicals with an estimated half-life of 10 days.
MNU is expected to hydrolyze in moist soils; therefore, MNU
adsorption and volatilization from soil are not expected to be
prevalent. In water,MNUis expected to hydrolyze and has a halflife
of 1.2 h at pH 7 and 20℃; therefore, volatilization,
adsorption into suspended solids and sediments, biodegradation,
and bioconcentration are not expected to be important
processes in aquatic systems. Occupational exposure to MNU
may occur through oral contact, inhalation, and/or dermal
contact at workplaces where it is used as a research chemical.
Potential exposure may occur during the preparation and
administration ofMNUor during clean up. To avoid spills,MNU
should be transported in securely sealed glass bottles or ampules,
which should themselves be placed inside strong screw-cap or
snap-top containers that will not open when dropped. Both
bottle and the outside container should be appropriately labeled.
N-니트로소-N-메틸우레아 준비 용품 및 원자재
원자재
준비 용품
