디클로페낙 나트륨
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디클로페낙 나트륨 속성
- 녹는점
- 288-290°C
- 밀도
- 0.781 g/cm3
- 저장 조건
- room temp
- 용해도
- H2O: 50 mg/mL
- 물리적 상태
- 흰색 고체
- 산도 계수 (pKa)
- 4(at 25℃)
- 색상
- 흰색에서 거의 흰색
- 수용성
- 50mg/ml까지 물에 용해됩니다.
- Merck
- 14,3081
- BCS Class
- 2
- 안정성
- 안정적인.
- InChI
- InChI=1S/C14H11Cl2NO2.Na/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1
- InChIKey
- KPHWPUGNDIVLNH-UHFFFAOYSA-M
- SMILES
- C1(=CC=CC=C1CC([O-])=O)NC1=C(Cl)C=CC=C1Cl.[Na+]
- CAS 데이터베이스
- 15307-79-6(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | T,Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 25-36/37/38-63 | ||
| 안전지침서 | 22-36/37-45-36-26-60-20 | ||
| 유엔번호(UN No.) | UN 2811 6.1/PG 3 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | AG6330000 | ||
| 위험 등급 | 6.1(b) | ||
| 포장분류 | III | ||
| HS 번호 | 29224999 | ||
| 독성 | LD50 in mice, rats (mg/kg): ~390, 150 orally (Krupp) | ||
| 기존화학 물질 | KE-10179 |
디클로페낙 나트륨 C화학적 특성, 용도, 생산
물성
무색내지 미황색의 맑은 용액이 투명성 있는 용기에 든 점안제용도
1. 백내장 수술시 다음 증상의 방지.·수술 후 염증 ·수술 중 축동.
·수정체 축출과 인공수정체 삽입술과 관련된 낭포황반부종.
2. 전안부의 염증 치료.
·만성 결막염등 비감염성 염증 ·외상 후 염증.
개요
Diclofenac is a non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor (IC50s = 0.9-2.7 and 1.5-20 μM, for human COX-1 and COX-2, respectively). It is also an active metabolite of diclofenac methyl ester and diclofenac amide . Diclofenac inhibits release of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) induced by A23187 in isolated rat peritoneal neutrophils and macrophages (IC50s = 60 and 10 μM, respectively). Transdermal administration of diclofenac inhibits carrageenan-induced paw edema in rats. Formulations containing diclofenac have been used in the treatment of pain associated with osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.화학적 성질
Off-White Crystalline Solid용도
Diclofenac sodium is a nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor. Oxidation of diclofenac sodium produces the metabolite 4'-hydroxy diclofenac) which demonstrates specific inhibition of Cox-2. Inhibition of Cox by diclofenac and 4'-hydroxy diclofenac suppresses prostaglandin E2 synthesis, producing anti-inflammatory and analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils, preventing the formation of insoluble amyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9. It is also used as an inhibitor of Cox-1 and Cox-2.정의
ChEBI: Diclofenac sodium is the sodium salt of diclofenac. It contains a diclofenac(1-).World Health Organization (WHO)
The World Health Organization currently has no information to suggest that diclofenac is less safe than other widely available non-steroidal antiinflammatory substances of this type, or that children are particularly liable to react adversely. It is registered in many countries in several dosage forms, including a 12.5 mg suppository indicated for juvenile arthritis.일반 설명
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.Diclofenac is a derivative of benzeneacetic acid. It is categorized under the class of non-steroidal anti-inflammatory drugs (NSAIDs). It shows inflammatory, analgesic and antipyretic activities.
Clinical Use
Diclofenac sodium is indicated for the treatment of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.Synthesis
Synthesis: Acylation of N-phenyl-2,6- dichloroaniline with chloroacetyl chloride gives the corresponding chloroacetanilide, which is fused with aluminum chloride to give 1-(2,6- dichlorophenyl)-2-indolinone. Hydrolysis of the indolinone with dilute aqueous-alcoholic sodium hydroxide affords the desired sodium salt directly.
디클로페낙 나트륨 준비 용품 및 원자재
원자재
준비 용품
디클로페낙 나트륨 공급 업체
글로벌( 934)공급 업체
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