Ramatroban
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Ramatroban 속성
- 녹는점
- 134-135°
- 알파
- D +70.1° (c = 1.0 in methanol)
- 끓는 점
- 654.7±65.0 °C(Predicted)
- 밀도
- 1.43±0.1 g/cm3(Predicted)
- 저장 조건
- Sealed in dry,2-8°C
- 용해도
- DMSO: ≥40mg/mL
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 4.60±0.10(Predicted)
- 색상
- 하얀색
- CAS 데이터베이스
- 116649-85-5(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38 | ||
| 안전지침서 | 26-36/37/39-45 | ||
| WGK 독일 | 1 |
Ramatroban MSDS
3R-[[(4-Fluorophenyl)sulfonyl]amino]-1,2,3,4-tetrahydro-9H-. carbazole-9-propanoic acid
Ramatroban C화학적 특성, 용도, 생산
개요
Ramatroban, originally developed for the treatment of cardiovascular pathologies as thromboembolism, was finally introduced in Japan for the treatment of allergic rhinitis. It is a (3R)-enantiomer that can be synthesized in 5 steps from 3-oxo-1,2,3,4- tetrahydrocarbazole by stereoselective reductive amination, using S-phenethylamine as the chiral source, followed by hydrogenolysis, sulfonylation and finally 2-step Ncarboxyethylation. Ramatroban is a potent antagonist of prostaglandin receptors (PGD2, PGH2) and thromboxane receptors (TxA2); accordingly, it blocks the contractions induced by thromboxane or TxA2-mimetics in animal and human airway smooth muscle. It also prevents, when administered i.v., p.o. or by aerosol, bronchoconstriction induced by PGD2 or antigen. In animal models of nasal allergy, ramatroban inhibits antigen-induced neutrophil infiltration into nasal mucosa and also inhibits nasal symptoms. In several species including humans, it is well-absorbed, extensively protein-bound (>95%) and eliminated mainly as a glucuro-conjugate; in man, its terminal half-life is 2 to 3 hours.화학적 성질
WHite to Off-White Solid용도
A thromboxane receptor antagonist for use in the treatment of coronary artery disease.생물학적 활성
Potent dual antagonist of TP/DP 2 (CRTH2) prostanoid receptors (K i values are 4.3, 4.5 and > 10000 nM for hDP 2 , hTP and hDP 1 receptors respectively). Suppresses PGD 2 -induced migration of human eosinophils (IC 50 = 170 nM).Ramatroban 준비 용품 및 원자재
원자재
Benzenesulfonamide, N-[(3R)-9-(2-cyanoethyl)-2,3,4,9-tetrahydro-1H-carbazol-3-yl]-4-fluoro-
5-옥소-테트라하이드로카르바졸에틸렌케탈
1,2,4,9-테트라히드로-카바졸-3-원
(R)-3-아미노-1,2,3,4-테트라하이드로카바졸
1,4-다이옥사스피로[4.5]데칸-8-온
페닐히드라진
준비 용품
Ramatroban 공급 업체
글로벌( 190)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9339 | 55 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Shaanxi Yikanglong Biotechnology Co., Ltd. | 17791478691 |
yklbiotech@163.com | CHINA | 296 | 58 |
| BOC Sciences | +1-631-485-4226 |
inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49391 | 58 |
| SIMAGCHEM CORP | +86-13806087780 |
sale@simagchem.com | China | 17367 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
Ramatroban 관련 검색:
글리신 카르바졸 트리스(하이드록시메틸)아미노메탄 2,3,5,6-테트라플루오로벤질 트랜스-2-(2,2-디클로로비닐)-3,3-디메틸사이클로프로판카르복실레이트 염화설퍼릴 플루오르벤젠알데히드 6-아미노 카프로산
Florfenicol
ALTRENOGEST
Para chloro benzenepropanoic acid
3-Amino-1,2,3,4-tetrahydrocarbazol
3-(3-METHYL-1H-INDOL-1-YL)PROPANOIC ACID
1H-PYRROLE-1-PROPANOIC ACID
1-INDOLEPROPIONIC ACID
(R)-3-Amino-1,2,3,4-tetrahydrocarbazole
3-(2-methyl-1H-indol-1-yl)propanoic acid
3-(2,3-DIMETHYL-INDOL-1-YL)-PROPIONIC ACID
etryptamine acetate