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티미딘

티미딘 구조식 이미지

카스 번호:: 50-89-5

한글명:: 티미딘

동의어(한글):: 티미딘

상품명:: Thymidine

동의어(영문):: DT;1-((2R,4S,5R)-4-Hydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-5-MethylpyriMidine-2,4(1H,3H)-dione;Deoxythymidine;β-Thymidine;b-Thymidine;Thymidin;Deoxyribothymidine;-Methylvalerophenone;THYMINE-2-DEOXYRIBOSIDE;Tyrosinase-related protein 2

CBNumber:: CB6134417

분자식:: C10H14N2O5

포뮬러 무게:: 242.23

MOL 파일:: 50-89-5.mol

MSDS 파일:: SDS

속성

안전

MSDS

용도

공급 업체 719

티미딘 속성

녹는점: 186-188 °C(lit.)

끓는 점: 385.05°C (rough estimate)

알파: 18.6 º (c=3, H2O)

밀도: 1.3129 (rough estimate)

굴절률: 33 ° (C=1, 1mol/L NaOH)

저장 조건: 2-8°C

용해도: 아세톤, DMSO(약간 용해됨), 에탄올, 에틸아세테이트, 메탄올(약간 용해됨, 가열)에 용해됨

산도 계수 (pKa): pK1:9.79;pK2:12.85 (25°C)

물리적 상태: 결정성 분말

색상: 흰색에서 거의 흰색

optical activity: [α]20/D +19±1°, c = 1% in H2O

수용성: 녹는

Merck: 14,9397

BRN: 89285

안정성: 안정적인. 강한 산화제와 호환되지 않습니다.

InChIKey: IQFYYKKMVGJFEH-XLPZGREQSA-N

LogP: -0.930

CAS 데이터베이스: 50-89-5(CAS DataBase Reference)

NIST: Thymidine(50-89-5)

EPA: Thymidine (50-89-5)

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

위험품 표기	Xi
위험 카페고리 넘버	20/21/22-40-36/37/38-68
안전지침서	22-24/25-37/39-26-36/37/39
WGK 독일	3
RTECS 번호	XP2071000
F 고인화성물질	10
TSCA	Yes
HS 번호	29335990
기존화학 물질	KE-09611

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	P- 코드
H315	피부에 자극을 일으킴	피부부식성 또는 자극성물질	구분 2	경고	P264, P280, P302+P352, P321,P332+P313, P362
H319	눈에 심한 자극을 일으킴	심한 눈 손상 또는 자극성 물질	구분 2A	경고	P264, P280, P305+P351+P338,P337+P313P
H335	호흡 자극성을 일으킬 수 있음	특정 표적장기 독성 - 1회 노출;호흡기계 자극	구분 3	경고

예방조치문구:

P261	분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P271	옥외 또는 환기가 잘 되는 곳에서만 취급하시오.
P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.

NFPA 704

	1
2		0

티미딘 MSDS

Thymine deoxyriboside

티미딘 C화학적 특성, 용도, 생산

개요

Thymidine is a pyrimidine nucleoside that is composed of the pyrimidine base thymine attached to the sugar deoxyribose. As a constituent of DNA, thymidine pairs with adenine in the DNA double helix. In cell biology it is used to synchronize the cells in G₁/early S phase.

화학적 성질

White needle crystal, soluble in methanol, ethanol, DMSO and other organic solvents.

물리적 성질

Thymidine can exist in vitro conditions as a solid (as white crystals or as white crystalline powder). Under standard temperature and pressure, the stability of this compound is very high. As a part of DNA structure, thymidine occurs in living organisms (also in DNA viruses). Therefore, it is a non-toxic compound. In RNA, there is uridine instead of thymidine. Uridine is formed from the combination of uracil with ribose sugar. The key difference between thymine and thymidine is that thymine is a nucleobase, whereas thymidine is a nucleoside.

용도

Thymidine is used in the syntheses of active pharmaceutical ingredient such as zidovudine. It also pairs with deoxyadenosine in double-stranded deoxyribonucleic acid. It is used to synchronize the cells in G1/early S phase in cell biology.

정의

ChEBI: Thymidine is a pyrimidine 2'-deoxyribonucleoside having thymine as the nucleobase. It has a role as a metabolite, a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is functionally related to a thymine. It is an enantiomer of a telbivudine.

일반 설명

Thymidine is also referred to as pyrimidine deoxynucleoside. Deoxythymidine is a nucleoside present in DNA. In a DNA double stranded structure, thymidine pairs with deoxyadeninosine.

Safety Profile

Moderately toxic by intraperitoneal route. An experimental teratogen. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

Crystallise -thymidine from ethyl acetate, MeOH/Et2O (m 188o) or H2O (as 2H2O m 189o). It is soluble in water and hot organic solvents. The picrate has m 230o (from EtOH).

티미딘 준비 용품 및 원자재

원자재

준비 용품

지도부딘 Stavudine 5-메틸시토신 5'-O-(4,4'-DIMETHOXYTRITYL)-N4-BENZOYL-5-METHYL-2'-DEOXYCYTIDINE 3',5'-DIACETYLTHYMIDINE

티미딘 공급 업체

글로벌( 719)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Yunbio Tech Co.,Ltd.	+86-010-60605551 +86-18046518538	yunbiochem@126.com	China	321	58
Wuhu Nuowei chemistry Co., Ltd.	+86-0553-2911116-802 +undefined17756524438	sales1@nuowei-chem.com	China	1642	58
SHANGHAI NOVRIBO BIOTECH	17821030819	June.Liu@Desano.com	China	73	58
Hu Bei Jiutian Bio-medical Technology CO.,Ltd	027-88013699 17354350817	Ryan@jiutian-bio.com	China	7433	58
Hebei Mojin Biotechnology Co., Ltd	+8613288715578	sales@hbmojin.com	China	12471	58
Hebei Guanlang Biotechnology Co,.LTD	+8619930503252	daisy@crovellbio.com	China	5963	58
Ouhuang Engineering Materials (Hubei) Co., Ltd	+8617702722807	admin@hbouhuang.com	China	3001	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	info@dakenam.com	China	15957	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1811	55

티미딘 관련 검색:

수용성전분 티민 지도부딘 티미딘 5-HYDROXYMETHYL-2'-DEOXYURIDINE T-SUCCINATE5'-O-DMTR-THYMIDINE-SUCCINATE 5’-o-[bis(4-methoxyphenyl)phenylmethyl]-thymidi THYMIDINE 5'-TRIPHOSPHATE SODIUM SALT,THYMIDINE-5'-TRIPHOSPHATE TETRASODIUM SALT,THYMIDINE-5'-TRIPHOSPHATE TRISODIUM SALT Trifluridine Thymidine-5'-monophosphate disodium salt 5’-o-(triphenylmethyl)-thymidi DMT-dT Phosphoramidite 5-Methyluridine 3’-deoxy-thymidi Deoxythymidine triphosphate 1-[(2S,4R,5S)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methyl-pyrimidine-2,4-dione 3’-deoxy-3’-fluoro-thymidi 2’,3’-didehydro-3’-deoxy-thymidi