Lithium diisopropylamide
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Lithium diisopropylamide 속성
- 녹는점
- decomposes [MER06]
- 끓는 점
- 65 °C
- 밀도
- 0.864 g/mL at 25 °C (lit.)
- 증기 밀도
- >1 (vs air)
- 인화점
- 91 °F
- 저장 조건
- 2-8°C
- 용해도
- soluble in ethyl ether; insoluble in hydrocarbon solvents
- 물리적 상태
- 액체
- 색상
- 갈색
- 수용성
- 물에서 분해되다
- 감도
- Air & Moisture Sensitive
- Merck
- 14,3196
- BRN
- 3655042
- CAS 데이터베이스
- 4111-54-0(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | C,N,F | ||
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위험 카페고리 넘버 | 14-17-34-67-65-51/53-35-19-15-11-50/53-14/15-10-40-23/24/25-62-63-37-48/20 | ||
안전지침서 | 26-36/37/39-43-45-60-61-62-8-16-23-33-27 | ||
유엔번호(UN No.) | UN 3399 4.3/PG 2 | ||
WGK 독일 | 3 | ||
F 고인화성물질 | 1-10 | ||
TSCA | Yes | ||
위험 등급 | 4.2 | ||
포장분류 | I | ||
HS 번호 | 29211990 |
그림문자(GHS): | ||||||||||||||||||||||
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신호 어: | Danger | |||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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Lithium diisopropylamide C화학적 특성, 용도, 생산
화학적 성질
Lithium diisopropylamide (LDA) is a white pyrophoric powder. Freshly prepared, it is soluble in hydrocarbons (in hexane about 10 %), but it tends to precipitate irreversibly from solution as a polymer on heating or prolonged storage. In ethers the solubility is much higher, but with the exception of tetrahydropyran, LDA is decomposed at a rate depending on the ether, concentration, and temperature.Lithium diisopropylamide can be conveniently prepared from butyllithium and diisopropylamine or purchased as a 2 mol/L (25 %) solution in THF and a mixture of various hydrocarbons. Although LDA is unstable in pure THF (at room temperature a 25% solution loses about 1% of its activity per day), the commercially available compositions containing only a limited amount of THF are satisfactory stable for technical applications.
용도
Lithium diisopropylamide is a sterically hindered nonnucleophilic strong base used for selective deprotonations, especially for the production of kinetic enolates (i.e., the thermodynamically less favored isomer) and (hetero-)aromatic carbanions. In the production of the serum lipid regulating agent Gemfibrozil one key intermediate is formed by quenching an ester enolate with 1-bromo-3-chloropropane.일반 설명
This material is in a solution of THF/Hexanes (ca. 1:7 ratio, respectively)Purification Methods
It is purified by refluxing over Na wire or NaH for 30minutes and then distilled into a receiver under N2. Because of the low boiling point of the amine, a dispersion of NaH in mineral oil can be used directly in this purification without prior removal of the oil. It is HIGHLY FLAMMABLE, and is decomposed by air and moisture. [Wittig & Hesse Org Synth 50 69 1970, Beilstein 4 H 154, 4 I 369, 4 II 630, 4 III 274, 4 IV 510.]Lithium diisopropylamide 준비 용품 및 원자재
원자재
준비 용품
3-FLUORO-2-IODOPYRIDINE-4-CARBOXYLIC ACID
Ethyl 2-oxocyclopentylacetate
6-FLUORO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBONITRILE
2-Chloro-4-iodopyridine-3-carboxaldehyde
5-AMINO-2-METHOXY-ISONICOTINIC ACID
1-(2,6-DIFLUOROPYRIDIN-3-YL)PROPAN-1-ONE
Ethyl 3-furancarboxylate
4-ALLYL-PIPERIDINE-1,4-DICARBOXYLICACMON-TERT-BUTYL에스테르
6-FLUORO-1H-PYRAZOLO[3,4-B]PYRIDINE-3-CARBOXYLIC ACID
4-Chloronicotinic acid
3-브로모티오펜-2-카르브알데히드
3-브로모티오펜-2-카르보닐클로라이드
3-플루오로퀴놀린-4-카르복실산
3-Chlorothiophene-2-carboxylic acid
1H-아제핀-3-카르복실산,헥사히드로-,메틸에스테르(9CI)
2-Fluoro-3-pyridylboronic acid
3-클로로티오펜-2-카르보닐클로라이드
리모나반트염산염
3-BROMOTHIOPHENE-2-CARBOXAMIDE
5-FLUORO-2-METHOXYPYRIDINE-4-BORONIC ACID
2-Methoxypyridine-3-boronic acid
(4-메톡시-1H-피롤로[2,3-B]피리딘-2-YL)
2-(4-METHOXY-1H-PYRROLO[2,3-B]PYRIDIN-2-YL)ETHANAMINE
4-METHOXY-1H-PYRROLO[2,3-B]PYRIDINE-2-CARBALDEHYDE
3-푸란메탄올
5-BROMO-2-FLUOROPYRIDINE-3-CARBALDEHYDE
에틸렌4-메톡시-1H-피롤로[2,3-B]피리딘-2-카복실레이트
1-(페닐술포닐)-1H-인돌-2-카르발데하이드
3,5-DIFLUOROPYRIDINE-4-CARBALDEHYDE
Lithium diisopropylamide 공급 업체
글로벌( 393)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12468 | 58 |
Hunan aslsen technology co.,ltd | +8619310186019 |
aslsb@aslsen.com | China | 128 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21688 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9341 | 55 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8829 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22968 | 58 |
Shandong chuangyingchemical Co., Ltd. | 18853181302 |
sale@chuangyingchem.com | CHINA | 5909 | 58 |
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