ECOTHIOPATE IODIDE
|
|
ECOTHIOPATE IODIDE 속성
- 녹는점
- 138° (Tammelin); mp 124-124.5° (Fitch)
- 저장 조건
- Store at -20°C
- 용해도
- DMSO: Slightly Soluble; Methanol: Slightly Soluble; Water: Slightly Soluble
- 물리적 상태
- 고체
- 안정성
- 흡습성
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 유엔번호(UN No.) | 3249 | ||
|---|---|---|---|
| 위험 등급 | 6.1(a) | ||
| 포장분류 | II |
ECOTHIOPATE IODIDE C화학적 특성, 용도, 생산
용도
Cholinergic (ophthalmic).용도
Echothiophate is a phosphorylthiocholine with pharmacological action analogous to that of isofluorophate; however, spontaneous reduction of phosphorylated enzyme occurs faster after using isofluorophate. It is used in various forms of glaucoma.정의
ChEBI: The iodide salt of ecothiopate. An irreversible acetylcholinesterase inhibitor, it is used an ocular antihypertensive in the treatment of open-angle glaucoma, particularly when other drugs have proved inadequate.Clinical Use
Echothiophate iodide has found therapeutic application for the treatment of glaucoma and strabismus. Echothiophate is applied topically as a solution and is the only irreversible AChEI for the treatment of glaucoma. The decrease in intraocular pressure observed can last up to 4 weeks. Phosphoester AChEIs exhibit cataractogenic properties; thus, their use should be reserved for patients who are refractory to other forms of treatment (i.e., short-acting miotics, β-blockers, epinephrine, and possibly, carbonic anhydrase inhibitors). Because of its toxicity, echothiophate is not used for its systemic action. Selectivity of echothiophate for the AChE catalytic site was enhanced by incorporation in the molecule of a quaternary ammonium salt functional group two carbons removed from the phosphoryl group.Synthesis
Echothiophate, S-(2-trimethylaminoethyl)-O,O-diethylthiophosphate (13.2.23), is made by reacting diethylchlorophosphoric acid with 2-dimethylaminoethylmercaptane, giving S-(2-dimethylaminoethyl)-O,O-diethylthiophosphate (13.2.22), which is alkylated by methyliodide, forming echothiophate (13.2.23) [51].
ECOTHIOPATE IODIDE 준비 용품 및 원자재
원자재
준비 용품
ECOTHIOPATE IODIDE 공급 업체
글로벌( 15)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| AFINE CHEMICALS LIMITED | 0571-85134551 18958018566; |
info@afinechem.com | China | 15377 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 |
support@targetmol.com | United States | 19973 | 58 |
| BOC Sciences | 1-631-485-4226; 16314854226 |
info@bocsci.com | United States | 14059 | 65 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 |
sales@chemegen.com | China | 11289 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 |
marketing@energy-chemical.com | China | 44941 | 58 |
| TargetMol Chemicals Inc. | 4008200310 |
marketing@tsbiochem.com | China | 24018 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 |
customer_service@efebio.com | China | 8740 | 58 |
| Hebei Zhentian food additives Co., LTD | 0319-5925599 13373390591 |
13373390591@163.com | China | 11423 | 58 |
| RD International Technology Co., Limited | 18024082417 |
market@ubiochem.com | China | 9180 | 58 |