셀로시딘
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셀로시딘 속성
- 녹는점
- 179 °C
- 끓는 점
- 209.98°C (rough estimate)
- 밀도
- 1.4421 (rough estimate)
- 굴절률
- 1.4610 (estimate)
- 저장 조건
- Store at -20°C
- 용해도
- DMF: 10 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2) (1:7): 0.12 mg/ml
- 물리적 상태
- 미세 결정성 분말
- 산도 계수 (pKa)
- 13.01±0.50(Predicted)
- 색상
- 크림부터 베이지까지
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | T | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 25-21 | ||
| 안전지침서 | 45-36/37-28A | ||
| HS 번호 | 29241900 | ||
| 독성 | LD50 i.v. in mice: 11 mg/kg (Suzuki) | ||
| 기존화학 물질 | KE-05-0280 | ||
| 유해화학물질 필터링 | 97-1-135 | ||
| 함량 및 규제정보 | 물질구분: 유독물질; 혼합물(제품)함량정보: 셀로시딘 및 이를 1% 이상 함유한 혼합물 |
셀로시딘 C화학적 특성, 용도, 생산
개요
Cellocidin is an antibiotic originally isolated from S. chibaensis. It is active against various bacterial strains including M. tuberculosis and against the trypanosomes T. brucei and T. rhodesiense (IC50s = 150 and 30 ng/ml, respectively). It inhibits proliferation of LCL1 and LCL2 cells transformed by Epstein-Barr virus (EBV), activates the c-Myc and NF-κB pathways in BC3 and LCL1 cells, and induces necrotic cell death in B cells infected with gammaherpes virus. Cellocidin (100-200 ppm) is protective against bacterial leaf blight in rice plants and inhibits α-ketoglutarate oxidation in X. oryzae, the bacterium that causes leaf blight, when used at a concentration of 1 ppm, suggesting that it inhibits the citric acid cycle. Formulations containing cellocidin have been used as agricultural pesticides.화학적 성질
CREAM TO BEIGE FINE CRYSTALLINE POWDER용도
Cellocidin is a small neutral alkyne produced by a number of Streptomyces species, first discovered by Suzuki and colleagues in 1958. Cellocidin has a broad antibacterial, antifungal and antitumor profile due to its ability to react with endogenous thiols like cysteine and glutathione. Cellocidin occurs as a weak active in many bioassays using actinomycete crude extracts and is thus a useful standard for chemical and bioassay dereplication.정의
ChEBI: A dicarboxylic acid diamide resulting from the formal condensation of both of the carboxy groups of butynedioic acid with ammonia. An antibacterial agent produced by Streptomyces chibaensis.Purification Methods
Acetylenedicarboxamide crystallises from MeOH and H2O [m 190-192o(dec) as hemihydrate]. When prepared from the ester + NH3 it has m 213o(dec). Also a melting point of 290-292o(dec) has been reported. [Saggimo J Org Chem 22 1171 1857, Kharash et al. J Org Chem 10 392 1945, Blomquist & Winslow J Org Chem 10 156 1945, Beilstein 2 I 317, 2 III 1995, 2 IV 2295.]셀로시딘 준비 용품 및 원자재
원자재
준비 용품
셀로시딘 공급 업체
글로벌( 40)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
| BOC Sciences | 16314854226; +16314854226 |
inquiry@bocsci.com | United States | 19743 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 |
info@dycnchem.com | CHINA | 52867 | 58 |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 |
1026@dideu.com | China | 9020 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 |
info@gihichemicals.com | China | 50000 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 52927 | 58 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 021-61259108 18621169109 |
market03@meryer.com | China | 40240 | 62 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 |
3bsc@sina.com | China | 15848 | 69 |
| Hangzhou Yuhao Chemical Technology Co., Ltd | 0571-82693216 |
info@yuhaochemical.com | China | 9394 | 52 |