Montelukast
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Montelukast 속성
- 녹는점
- 145-148 °C(Solv: toluene (108-88-3); methanol (67-56-1))
- 끓는 점
- 750.5±60.0 °C(Predicted)
- 밀도
- 1.272±0.06 g/cm3(Predicted)
- 저장 조건
- Store at 2-8°C
- 용해도
- DMF: 2 mg/ml,DMSO: 2 mg/ml,Ethanol: insol,PBS (pH 7.2): insol
- 물리적 상태
- 고체
- 산도 계수 (pKa)
- 4.76±0.10(Predicted)
- CAS 데이터베이스
- 158966-92-8(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
유해 물질 데이터 | 158966-92-8(Hazardous Substances Data) |
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Montelukast C화학적 특성, 용도, 생산
용도
cardiostimulant,Mechanism of action
Montelukast was developed from other weakly antagonistic quinoline derivatives. A number of changes can be made to the structure without the loss of activity. These include changing the double bond between the two aromatic rings to an ether linkage, reducing the quinoline ring, changing the chlorine to a fluorine, and/or exchanging the sulfur for an amide group.Pharmacokinetics
Montelukast is a high-affinity, selective antagonist of the cysLT1 receptor. It is rapidly absorbed orally, with a bioavailability of 64%. Montelukast is 99% bound to plasma proteins and is extensively metabolized in the liver by CYP3A4 and CYP2C9 to oxidated products. CYP3A4 oxidizes the sulfur and the C-21 benzylic carbon, whereas CYP2C9 is selectively responsible for the methyl hydroxylation.부작용
Montelukast did not demonstrate any significant adverse effects greater than placebo in clinical trials; however, because it is metabolized by the cytochrome P450 (CYP450) enzymes, its plasma levels should be monitored when coadministered with CYP450-inducing drugs, such as phenobarbital, rifampin, and phenytoin.Montelukast 준비 용품 및 원자재
원자재
실리카겔
터트-뷰틸클로로다이메틸실란
염화나트륨
다이에틸아민
브로민화 바이닐(브롬화 비닐)
아세트산 암모늄
사이안화 나트륨
methyl 2-(2-iodophenyl)propanoate
메탄설포닐 클로라이드
크로톤알데하이드
Vinylmagnesium bromide
메틸마그네슘 염화물
Borane-tetrahydrofuran complex
세륨(III) 클로라이드
Diethyl 1,1-cyclopropanedicarboxylate
염화 티오닐
사염화-1,4-벤조퀴논
P-클로로아닐린
테트라뷰틸암모늄 클로라이드
아세트산 팔라듐 (II)
포타슘터셔리부톡사이드
N,N-다이아이소프로필에틸아민
트리에틸아민
준비 용품
Montelukast 공급 업체
글로벌( 200)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 |
sales03@chemcn.cn | China | 971 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21687 | 55 |
Shenzhen Excellent Biotech Co., Ltd. | 13480692018 |
ramyan@ex-biotech.com | CHINA | 954 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49391 | 58 |
career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |
Wuhan Monad Medicine Tech Co.,LTD | 02768782018 18771942761 |
sales01@whmonad.com | CHINA | 992 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
ANHUI WITOP BIOTECH CO., LTD | +8615255079626 |
eric@witopchemical.com | China | 23556 | 58 |
Xi'an MC Biotech, Co., Ltd. | 029-89275612 +8618991951683 |
mcbio_sales@163.com | China | 2255 | 58 |
Montelukast 관련 검색:
디페닐에테르 트리에톡시비닐실란 퀸하이드론 헵타클로르 에폭시드 1-히드록시에틸리덴-1,1-디포스포닌산 에틸 트리 페닐 포스 포늄 브로마이드 비닐 프로피온산염 페닐초산 클로로디플루오르메탄
Montelukast sodium
4-Ethyl-5-fluoro-6-hydroxypyrimidine
CHLOROPHOSPHONAZO III
Monomethyl fumarate
Monosulfuron
Methyl [E]-2-[3-(S)-[3-[2-(7-Chloro-2-quinolinyl)ethenyl]phenyl]-3-hydroxypropyl]benzoate
Pirbuterol
PHENYL VALERATE
Tranilast