아세토바닐론
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아세토바닐론 속성
- 녹는점
- 112-115 °C (lit.)
- 끓는 점
- 263-265 °C/17 mmHg (lit.)
- 밀도
- 1.1708 (rough estimate)
- 굴절률
- 1.5101 (estimate)
- 인화점
- >230 °F
- 저장 조건
- Sealed in dry,Room Temperature
- 용해도
- 아세토니트릴(약간 용해됨), 클로로포름(약간 용해됨), 에틸아세테이트(약간 용해됨), 메탄
- 산도 계수 (pKa)
- 8.18±0.18(Predicted)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 색상
- 노란색에서 갈색으로
- 냄새
- 100.00%에서. 희미하고 달콤한 바닐린
- ?? ??
- 바닐라
- 수용성
- 뜨거운 물에 용해됨
- Merck
- 14,741
- BRN
- 637373
- LogP
- 1.389 (est)
- CAS 데이터베이스
- 498-02-2(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xi | ||
---|---|---|---|
위험 카페고리 넘버 | 36/37/38 | ||
안전지침서 | 26-36 | ||
WGK 독일 | 2 | ||
RTECS 번호 | AM8800000 | ||
TSCA | Yes | ||
HS 번호 | 29145000 | ||
기존화학 물질 | KE-20625 |
아세토바닐론 C화학적 특성, 용도, 생산
화학적 성질
Acetovanillone is a yellowish to brown powder, soluble in alcohol, essential oils, and perfume chemicals. It is slightly soluble in water at room temperature but readily dissolves in hot water. It has a very faint, sweet odor, faintly reminiscent of vanillin, but with less spiciness and somewhat fresher notes. It occurs widely in nature, including in Orris root distillate.용도
Acetovanillone is an inhibitor of NADPH oxidase (an enzyme responsible for reactive oxygen species production) and is useful in the treatment of various inflammatory diseases.정의
ChEBI: Apocynin is an aromatic ketone that is 1-phenylethanone substituted by a hydroxy group at position 4 and a methoxy group at position 3. It has a role as a non-narcotic analgesic, a non-steroidal anti-inflammatory drug, an antirheumatic drug, a peripheral nervous system drug, an EC 1.6.3.1. [NAD(P)H oxidase (H2O2-forming)] inhibitor and a plant metabolite. It is a member of acetophenones, a methyl ketone and an aromatic ketone.제조 방법
Synthetically by methylation of 3,4-Dihydroxyacetophenone. It can also be obtained by Fries rearrangement of guaiacol acetate in the presence of zinc chloride. It can be isolated from the extract of the roots of Indian hemp, Apocynum cannabinum L.생산 방법
Synthetically by methylation of 3,4- Dihydroxy acetophenone. Also from Guaiacol acetate with Zinc chloride and Acetic anhydride. Can be isolated from the extract of the roots of Indian hemp, Apocynum cannabinum L.일반 설명
Acetovanillone is an aromatic plant ketone, which is a selective inhibitor of NADPH oxidase. It is mainly secreted in the urine of mammals as the corresponding glucuronide conjugate.Purification Methods
Crystallise apocynin from water, or EtOH/pet ether. [Beilstein 8 IV 1814.]참고 문헌
[1] GARA N DEXTER. Bacterial catabolism of acetovanillone, a lignin-derived compound.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2022: e2213450119. DOI:10.1073/pnas.2213450119.[2] YUDAI HIGUCHI. The Catabolic System of Acetovanillone and Acetosyringone in Sphingobium sp. Strain SYK-6 Useful for Upgrading Aromatic Compounds Obtained through Chemical Lignin Depolymerization.[J]. Applied and Environmental Microbiology, 2022, 88 16: e0072422. DOI:10.1128/aem.00724-22.
[3] CHIARA RIGANTI. The NADPH oxidase inhibitor apocynin (acetovanillone) induces oxidative stress[J]. Toxicology and applied pharmacology, 2006, 212 3: Pages 179-187. DOI:10.1016/j.taap.2005.07.011.
[4] GJERTSEN FB Scheline R Solheim E. Metabolism of aromatic plant ketones in rats: Acetovanillone and paeonol[J]. Journal of ethnopharmacology, 1988, 23 2: Page 342. DOI:10.1016/0378-8741(88)90035-9.
아세토바닐론 준비 용품 및 원자재
원자재
준비 용품
2,4-펜탄디온
4-Hydroxy-3-methoxystyrene
METHOXYBENZOQUINONE
4-chloro-6,7-dimethoxyquinoline
1-(2-히드록시-3-메톡시-페닐)에타논
1-(4,5-디메톡시-2-니트로-페닐)-에타논
4-에틸-1,3-디히드록시벤젠
4-METHOXY-3-HYDROXYACETOPHENONE
2,4-Dimethoxyacetophenone
Quinoline, 4-chloro-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-
4-(4-아세틸-2-메톡시페녹시)-부탄산에틸에스테르
2-브로모-1-(4-하이드록시-3-메톡시페닐)에타논
아세토바닐론 공급 업체
글로벌( 510)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12468 | 58 |
Hubei Langyou International Trading Co., Ltd | +8618874586545 |
linda@xrdchem.cn | China | 197 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 18219 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618740459177 |
sarah@tnjone.com | China | 1142 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21688 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32686 | 60 |
Anqing Chico Pharmaceutical Co., Ltd. | 15380796838 |
chloewu@chicopharm.cn | CHINA | 341 | 58 |
Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |