노스카빈
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노스카빈 속성
- 녹는점
- 174-176 °C(lit.)
- 알파
- -200 º (c=1 in chloroform)
- 끓는 점
- 532.6°C (rough estimate)
- 밀도
- 1.395
- 굴절률
- 1.5614 (estimate)
- 저장 조건
- -20°C Freezer, Under Inert Atmosphere
- 용해도
- 물에는 거의 녹지 않으며, 아세톤에는 녹고, 에탄올에는 약간 녹습니다(96%). 강산에 용해됩니다. 용액을 물로 희석하면 염기가 침전될 수 있습니다.
- 산도 계수 (pKa)
- 7.8(at 25℃)
- 색상
- 에탄올로부터 침전된 사방정계 프리즘 결정
- optical activity
- [α]20/D 200°, c = 1 in chloroform
- 수용성
- 302.9mg/L(25 ºC)
- Merck
- 13,6752
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
---|---|---|---|
위험 카페고리 넘버 | 22 | ||
안전지침서 | 24/25 | ||
유엔번호(UN No.) | 1544 | ||
WGK 독일 | 3 | ||
RTECS 번호 | RD2625000 | ||
위험 등급 | 6.1(b) | ||
포장분류 | III | ||
HS 번호 | 29329990 | ||
유해 물질 데이터 | 128-62-1(Hazardous Substances Data) | ||
독성 | cyt-ham:lng 100 mg/L ATSUDG (4),41,80 |
그림문자(GHS): | ||||||||||||||||||||||
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신호 어: | Warning | |||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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노스카빈 C화학적 특성, 용도, 생산
개요
A major constituent of opium (Papaver sornni!erurn), this phthalideisolquinoline base was probably first discovered by Derosne, but initially characterized by Robiquet who gave it the formula C23H3S0 7N, changed to that now accepted by Matthiesen and Foster. It crystallizes in colourless needles from EtOH and has [α]D - 198° (c 1.0, CHC13); - 146° (c 2.0, toluene); - 147° (c 1.59, C6H6) and + 50° (1 % HCl). The alkaloid is a weak, monoacidic, tertiary base, forming unstable salts with acids which are dissociated with H20. The hydrochloride crystallizes with varying amounts of H20, is very soluble in water, readily decomposing into basic salts on standing. The platinichloride is amorphous; the oxalate has m.p. 174°C;[α]20D + 39.5° (H20); the phthalate, m.p. 160°C; [α]22D + 115° (CHC13); sesquisulphate, colourless crystals of the hexahydrate and the picrate, m.p. 1 74-S°C. The (+)-bromocamphorsulphonate has m.p. 110- 120°C; [α]D + 100.7° (CHC13) and the corresponding (-)-bromocamphorsul_x0002_phonate, m.p. l80.SoC; [α]D + 29° (CHC13). The alkaloid yields an N-oxide which is a hygroscopic solid; [α]D + 135° (CHC13) furnishing a crystalline hydrochloride, m.p. 193°C; platinichloride, m.p. 175°C and a picrate, m.p. 130°C.The base is unstable to heat and when heated in a sealed tube yields a mixture of dimethylnornarcotine, methylnornarcotine and nornarcotine. On heating with H20 and 150°C, or on boiling with dilute acids, it is hydrolyzed to opianic acid and hydrocotarnine. Similar degradations are brought about by acid oxidation orreduction, e.g. Zn and dilute HCl gives hydrocotarnine and meconin while dilute HN03 yields cotarnine and opianic acid. Pharmacologically, narcotine resembles thebaine (q.v.) in its action, being a reflex stimulant rather than a narcotic.
화학적 성질
Crystalline Solid정의
ChEBI: A benzylisoquinoline alkaloid that is 1,2,3,4-tetrahydroisoquinoline which is substituted by a 4,5-dimethoxy-3-oxo-1,3-dihydro-2-benzofuran-1-yl group at position 1, a methylenedioxy group at positions 6-7 and a methoxy group at position 8. Obtained from p ants of the Papaveraceae family, it lacks significant painkilling properties and is primarily used for its antitussive (cough-suppressing) effects.World Health Organization (WHO)
Noscapine, a centrally-acting cough suppressant and one of several alkaloids present in papaveretum (opium concentrate) was introduced into medicine many years ago. Subsequently, it was shown to increase the number of chromosomes in mammalian cell lines maintained in vitro. Although the clinical significance of this finding is uncertain, restrictive action was taken in a few countries since the possibility of a genotoxic effect cannot be excluded. On 4 December 1992 the European Committee on Proprietary Medicinal Products concluded that the available evidence does not indicate that use of noscapine holds any significant hazard. The Swedish Medical Products Agency also concluded that there is no justification to restrict the use of noscapine in women of childbearing age.Biological Functions
Noscapine is a naturally occurring product of the opium poppy. It is a benzylisoquinoline with no analgesic or other CNS effects. Its antitussive effects are weak, but it is used in combination with other agents in mixtures for cough relief.위험도
Narcotic, use legally restricted.Safety Profile
Moderately toxic by ingestion andsubcutaneous routes. Mutation data reported. Anantitussive. When heated to decomposition it emits toxicfumes of NOx.참고 문헌
Robiquet., Ann. Chim. Phys., 5,275 (1817)Matthiessen, Foster.,!. Chern. Soc., 16,342 (1863)
Perkin, Robinson., ibid, 99,775 (1911)
Polonovski, Polonovski., Bull. Soc. Chim. Fr., 47, 361 (1930)
Lovell., Acta Cryst., 6, 869 (1953)
Barnes., Can. f. Chern., 33,444 (1955)
Safe, Moir., ibid, 160 (1964)
Stereochemistry: Battersby, Spenser., Tetrahedron Lett., 11 (1964)
노스카빈 준비 용품 및 원자재
원자재
준비 용품
노스카빈 공급 업체
글로벌( 132)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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Gansu Agricultural Reclamation Medical Alkaloids Factory Co., Ltd | +86-13909357309; +8613909357309 |
eky7309@126.com | China | 3 | 58 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | China | 2931 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
career henan chemical co | +86-0371-86658258 15093356674; |
factory@coreychem.com | China | 29826 | 58 |
Hubei Ipure Biology Co., Ltd | +8613367258412 |
ada@ipurechemical.com | China | 10326 | 58 |
Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 |
sales@tnjchem.com | China | 34571 | 58 |
HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6313 | 58 |
sgtlifesciences pvt ltd | +8617013299288 |
dj@sgtlifesciences.com | China | 12382 | 58 |
Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 |
1026@dideu.com | China | 9020 | 58 |
Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 |
sales@chemhifuture.com | China | 3136 | 58 |
노스카빈 관련 검색:
노스카빈 로무스팅
Narcotine, hydrochloride (7CI, 8CI),l-Narcotine hydrochloride,NARCOTINE HYDROCHLORIDE
Acrivastine
Simvastatin
(S)-2-Amino-5-methoxytetralin (S)-mandelate
tert-Butyl rosuvastatin
2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol
Epinastine hydrochloride
O-HYDROXY ATORVASTATIN LACTONE
Cilastatin
(RS)-N-Methyl-gama-(1-naphthalenyloxy)-2-thiophenepropanamine hydrochloride
Methyl(+)-(3-R)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesul
fonylamino) pyrimidin-5-yl]-3-hydroxy-5-oxo-6(E)-heptenoate
NORFLUOXETINE HYDROCHLORIDE
(S)-2-Amino-5-methoxytetralin Hydrochloride
Fluvastatin sodium salt
LEVOCABASTINE
P-HYDROXY ATORVASTATIN LACTONE