파조파닙
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파조파닙 속성
- 녹는점
- 285-289°C (dec.)
- 끓는 점
- 728.8±70.0 °C(Predicted)
- 밀도
- 1.40
- 인화점
- 359℃
- 저장 조건
- Refrigerator
- 용해도
- 수용액(약간 용해됨), DMSO(약간 용해됨, 가온), 메탄올(약간 용해됨, 가온)
- 산도 계수 (pKa)
- 10.19±0.60(Predicted)
- 물리적 상태
- 노란색 가루.
- 색상
- 흰색에서 베이지색
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험 카페고리 넘버 | 43-62/63 | ||
|---|---|---|---|
| 안전지침서 | 36/37/39-28B | ||
| HS 번호 | 29350090 | ||
| 유해 물질 데이터 | 444731-52-6(Hazardous Substances Data) |
| 그림문자(GHS): |
 
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| 신호 어: | Danger | |||||||||||||||||||||
| 유해·위험 문구: |
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| 예방조치문구: |
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파조파닙 C화학적 특성, 용도, 생산
개요
Pazopanib is a multi-kinase inhibitor that inhibits the VEGF receptors VEGFR1, VEGFR2, and VEGFR3 (IC50s = 10, 30, and 47 nM, respectively, in a cell-free enzyme assay). It also inhibits PDGFRα, PDGFRβ, and c-Kit (IC50s = 71, 84, and 74 nM, respectively, in a cell-free enzyme assay) as well as additional receptor tyrosine kinases. Pazopanib inhibits upregulation of the surface adhesion proteins ICAM-1 and VCAM-1 induced by VEGF in multiple myeloma cells cocultured with human umbilical vein endothelial cells (HUVECs) and decreases multiple myeloma cell adhesion to HUVECs. It also inhibits proliferation of multiple myeloma cells cocultured with HUVECs. Pazopanib (30 and 100 mg/kg) reduces tumor growth, induces apoptosis, decreases angiogenesis, and increases survival in a multiple myeloma mouse xenograft model. Formulations containing pazopanib have been used in the treatment of cancer.화학적 성질
Off-White SolidCharacteristics
Class: receptor tyrosine kinaseTreatment: RCC, STS
Oral bioavailability = 14–39%
Elimination half-life = 31 h
Protein binding > 99.9%
용도
Pazopanib Hydrochloride (GW786034, Votrient, Armala) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM, respectively.정의
ChEBI: A pyrimidine that is 5-(pyrimidin-2-yl}amino-2-methylbenzenesulfonamide substituted at position 4 by a (2,3-dimethylindazol-6-yl)(methyl)amino group. Used as its hydrochloride salt for treatment of kidney cancer.파조파닙 준비 용품 및 원자재
원자재
준비 용품
파조파닙 공급 업체
글로벌( 419)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Yangzhou Qinyuan Pharmatech Co.,ltd | +86-18752526868 |
jennysun@yzqyyykj.com | China | 71 | 58 |
| Shandong Risen-Sun Pharmaceutical Co., Ltd | +86-15552509998 +86-15621883869 |
liutf@jewim.com.cn | China | 251 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 6011 | 58 |
| shandong perfect biotechnology co.ltd | +86-53169958659; +8618596095638 |
sales@sdperfect.com | China | 294 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 |
Mandy@hangyubiotech.com | China | 11013 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 18218 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 |
sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
| Hi-Tech Chemistry Corp | 0519-86626038 |
yuhh@hitechem.com | CHINA | 811 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21688 | 55 |
파조파닙 관련 검색:
N,N-다이메틸폼아마이드 파라-톨루엔설폰아마이드 설파닐아미드 자일렌 다이메틸 설폭사이드 디메틸설페이트 다이메틸 프탈레이트 다이메틸 푸마르산 벤젠설폰아미드 디메틸 카보네이트 다이메틸-p-페닐엔디아민 에탄 디메틸 에테르
3-Methyl-6-nitroindazole
Dacthal
3-Aminobenzenesulfonamide
N-(2-chloropyriMidin-4-yl)-N,2,3-triMethyl-2H-indazol-6-aMine
N-(2-Chloropyrimidin-4-YL)-2,3-dimethyl-2H-indazol-6-amine